Showing papers by "Xiamen University published in 2009"
TL;DR: The protein kinase receptor-interacting protein 3 (RIP3) was identified as a molecular switch between TNF-induced apoptosis and necrosis in NIH 3T3 cells and found that RIP3 was required for necrosisin other cells.
Abstract: Necrosis can be induced by stimulating death receptors with tumor necrosis factor (TNF) or other agonists; however, the underlying mechanism differentiating necrosis from apoptosis is largely unknown. We identified the protein kinase receptor-interacting protein 3 (RIP3) as a molecular switch between TNF-induced apoptosis and necrosis in NIH 3T3 cells and found that RIP3 was required for necrosis in other cells. RIP3 did not affect RIP1-mediated apoptosis but was required for RIP1-mediated necrosis and the enhancement of necrosis by the caspase inhibitor zVAD. By activating key enzymes of metabolic pathways, RIP3 regulates TNF-induced reactive oxygen species production, which partially accounts for RIP3's ability to promote necrosis. Our data suggest that modulation of energy metabolism in response to death stimuli has an important role in the choice between apoptosis and necrosis.
1,684 citations
TL;DR: Anatase TiO(2) nanosheets with highly reactive facets exposed have been successfully synthesized by a facile hydrothermal route, taking advantage of a specific stabilization effect of fluorine ion on (001) facets.
Abstract: Anatase TiO2 nanosheets with highly reactive (001) facets exposed have been successfully synthesized by a facile hydrothermal route, taking advantage of a specific stabilization effect of fluorine ion on (001) facets. The percentage of highly reactive (001) facets in such TiO2 nanosheets is very high (up to 89%). In addition, the as-prepared TiO2 nanosheets exhibit excellent activity in the photocatalytic degradation of organic contaminants.
1,504 citations
TL;DR: Molecular beacons are specifically designed DNA hairpin structures that are widely used as fluorescent probes that enables the analysis of target oligonucleotides without the separation of unbound probes.
Abstract: Molecular beacons (MBs) are specifically designed DNA hairpin structures that are widely used as fluorescent probes. Applications of MBs range from genetic screening, biosensor development, biochip construction, and the detection of single-nucleotide polymorphisms to mRNA monitoring in living cells. The inherent signal-transduction mechanism of MBs enables the analysis of target oligonucleotides without the separation of unbound probes. The MB stem–loop structure holds the fluorescence-donor and fluorescence-acceptor moieties in close proximity to one another, which results in resonant energy transfer. A spontaneous conformation change occurs upon hybridization to separate the two moieties and restore the fluorescence of the donor. Recent research has focused on the improvement of probe composition, intracellular gene quantitation, protein–DNA interaction studies, and protein recognition.
590 citations
TL;DR: The existing methods to estimate the surface enhancement factor, a criterion to characterize the SERS activity of a substrate, are analyzed and some guidelines are proposed to obtain the correct enhancement factor.
Abstract: After over 30 years of development, surface-enhanced Raman spectroscopy (SERS) is now facing a very important stage in its history. The explosive development of nanoscience and nanotechnology has assisted the rapid development of SERS, especially during the last 5 years. Further development of surface-enhanced Raman spectroscopy is mainly limited by the reproducible preparation of clean and highly surface enhanced Raman scattering (SERS) active substrates. This review deals with some substrate-related issues. Various methods will be introduced for preparing SERS substrates of Ag and Au for analytical purposes, from SERS substrates prepared by electrochemical or vacuum methods, to well-dispersed Au or Ag nanoparticle sols, to nanoparticle thin film substrates, and finally to ordered nanostructured substrates. Emphasis is placed on the analysis of the advantages and weaknesses of different methods in preparing SERS substrates. Closely related to the application of SERS in the analysis of trace sample and unknown systems, the existing cleaning methods for SERS substrates are analyzed and a combined chemical adsorption and electrochemical oxidation method is proposed to eliminate the interference of contaminants. A defocusing method is proposed to deal with the laser-induced sample decomposition problem frequently met in SERS measurement to obtain strong signals. The existing methods to estimate the surface enhancement factor, a criterion to characterize the SERS activity of a substrate, are analyzed and some guidelines are proposed to obtain the correct enhancement factor.
548 citations
TL;DR: National Natural Science Foundation of China [20725310, 20721001, 20673085, 20801045]; National Basic Research Program of China[2007CB15303, 2009CB939804]
Abstract: National Natural Science Foundation of China [20725310, 20721001, 20673085, 20801045]; National Basic Research Program of China [2007CB15303, 2009CB939804]
451 citations
TL;DR: The cellular responses to hypoxia and HIF‐1 signaling pathway in Hypoxia are introduced, the multifaceted role of hypoxIA in the hallmarks of human cancers is summarized, and the complex mechanisms involved are summarized.
Abstract: Hypoxia has been recognized as one of the fundamentally important features of solid tumors and plays a critical role in various cellular and physiologic events, including cell proliferation, survival, angiogenesis, immunosurveillance, metabolism, as well as tumor invasion and metastasis. These responses to hypoxia are at least partially orchestrated by activation of the hypoxia-inducible factors (HIFs). HIF-1 is a key regulator of the response of mammalian cells to oxygen deprivation and plays critical roles in the adaptation of tumor cells to a hypoxic microenvironment. Hypoxia and overexpression of HIF-1 have been associated with radiation therapy and chemotherapy resistance, an increased risk of invasion and metastasis, and a poor clinical prognosis of solid tumors. The discovery of HIF-1 signaling has led to a rapidly increasing understanding of the complex mechanisms involved in tumor hypoxia and has helped greatly in screening novel anticancer agents. In this review, we will first introduce the cellular responses to hypoxia and HIF-1 signaling pathway in hypoxia, and then summarize the multifaceted role of hypoxia in the hallmarks of human cancers.
431 citations
TL;DR: Wang et al. as mentioned in this paper proposed a method to solve the problem of artificial neural networks in the field of computer vision and applied it to artificial intelligence in the context of artificial intelligence.
Abstract: National Nature Science Foundation of China [50571085, 20773100, 20620130427, 20773135]; National Basic Research Program of China 973 Program [2007CB935603]; Technology Program of Fujian and Xiamen, China [2007H0031, 3502Z20073004]; Chinese Academy of Sciences
429 citations
TL;DR: The emerging roles of miRNAs in the hallmarks of human cancers are discussed to provide potential diagnostic and prognostic tumor biomarkers and new therapeutic strategies to treat cancers.
424 citations
TL;DR: The National Natural Science Foundation of China as discussed by the authors [20725310, 20721001, 20673085, 20801045], National Basic Research Program of China [2007CB815303, 2009CB939804]
Abstract: National Natural Science Foundation of China [20725310, 20721001, 20673085, 20801045]; National Basic Research Program of China [2007CB815303, 2009CB939804]
342 citations
TL;DR: A density functional, XYG3, based on the adiabatic connection formalism and the Görling–Levy coupling-constant perturbation expansion to the second order is developed and validated and is remarkably accurate for thermochemistry, reaction barrier heights, and nonbond interactions of main group molecules.
Abstract: We develop and validate a density functional, XYG3, based on the adiabatic connection formalism and the Gorling–Levy coupling-constant perturbation expansion to the second order (PT2). XYG3 is a doubly hybrid functional, containing 3 mixing parameters. It has a nonlocal orbital-dependent component in the exchange term (exact exchange) plus information about the unoccupied Kohn–Sham orbitals in the correlation part (PT2 double excitation). XYG3 is remarkably accurate for thermochemistry, reaction barrier heights, and nonbond interactions of main group molecules. In addition, the accuracy remains nearly constant with system size.
340 citations
TL;DR: In this review, aspects related to the function of periostin in tumorigenesis are summarized.
Abstract: Periostin, also called osteoblast-specific factor 2 (OSF-2), is a member of the fasciclin family and a disulfide-linked cell adhesion protein that has been shown to be expressed preferentially in the periosteum and periodontal ligaments, where it acts as a critical regulator of bone and tooth formation and maintenance. Furthermore, periostin plays an important role in cardiac development. Recent clinical evidence has also revealed that periostin is involved in the development of various tumors, such as breast, lung, colon, pancreatic, and ovarian cancers. Periostin interacts with multiple cell-surface receptors, most notably integrins, and signals mainly via the PI3-K/Akt and other pathways to promote cancer cell survival, epithelial-mesenchymal transition (EMT), invasion, and metastasis. In this review, aspects related to the function of periostin in tumorigenesis are summarized.
TL;DR: An approach to multiattribute decision making with incomplete attribute weight information where individual assessments are provided as interval-valued intuitionistic fuzzy numbers (IVIFNs) is proposed by employing a series of optimization models.
TL;DR: This work shows that alongside the two classical covalent and ionic bond families, there exists a class of charge-shift bonds wherein the electron-pair fluctuation has the dominant role, and outlines new directions demonstrating the portability of the new concept.
Abstract: Electron-pair bonding is a central chemical paradigm. Here, we show that alongside the two classical covalent and ionic bond families, there exists a class of charge-shift (CS) bonds wherein the electron-pair fluctuation has the dominant role. Charge-shift bonding shows large covalent-ionic resonance interaction energy, and depleted charge densities, and features typical to repulsive interactions, albeit the bond itself may well be strong. This bonding type is rooted in a mechanism whereby the bond achieves equilibrium defined by the virial ratio. The CS bonding territory involves, for example, homopolar bonds of compact electronegative and/or lone-pair-rich elements, heteropolar bonds of these elements among themselves and with other atoms (for example, the metalloids, such as silicon and germanium), hypercoordinated molecules, and bonds whose covalent components are weakened by exchange-repulsion strain (as in [1.1.1]propellane). Here, we discuss experimental manifestations of CS bonding in chemistry, and outline new directions demonstrating the portability of the new concept.
TL;DR: NSF of China as discussed by the authors [20433040, 10474082, 20573087], National Basic Research Program of China [2007CB815303, 2009CB930703]
Abstract: NSF of China [20433040, 10474082, 20573087]; National Basic Research Program of China [2007CB815303, 2009CB930703]
TL;DR: In this paper, the authors showed that carbon nanotubes (CNTs) were the most efficient support of Ru for cellulose conversion, and the mean size of Ru nanoparticles over CNT was ~8.8nm.
Abstract: Cellulose samples with different crystallinities (33–85%) were prepared by treating a commercial cellulose (crystalline, 85%) with phosphoric acid under different conditions. Supported Fe, Co, Ni, Pd, Pt, Rh, Ru, Ir, Ag, and Au catalysts were examined for the conversion of cellulose with a crystallinity of 33% in water medium in the presence of hydrogen, and Ru was found to be the most effective catalyst for the formation of sorbitol. We demonstrated that carbon nanotubes (CNTs) were the most efficient support of Ru for cellulose conversion, and the mean size of Ru nanoparticles over CNT was ~8.8 nm. NH3-TPD and H2-TPD characterizations suggest that plenty of acid sites and unique hydrogen species over the Ru/CNT are important for sorbitol formation through hydrolysis and hydrogenation of cellulose. A 40% yield of hexitols (including 36% of sorbitol) could be achieved over the Ru/CNT catalyst for the conversion of the commercial cellulose (crystalline, 85%), and this yield was the highest one reported to date for the direct conversion of cellulose into sugar alcohols.
TL;DR: In this article, a new concept of Granger causality in risk is introduced and a class of kernel-based tests are proposed to detect extreme downside risk spillover between financial markets, where risk is measured by the left tail of the distribution or equivalently by the Value at Risk (VaR).
TL;DR: A synthetic strategy has been developed to prepare single-crystalline hollow Pd/Pt nanocubes that increase accessible surface area and therefore improve electrocatalytic activity in formic acid oxidation.
Abstract: Efficiency simplified: A synthetic strategy has been developed to prepare single-crystalline hollow Pd/Pt nanocubes (right, see picture; left: nanocubes). Compared to the solid Pd/Pt nanocubes of similar sizes, the hollow Pd/Pt nanocubes increase accessible surface area and therefore improve electrocatalytic activity in formic acid oxidation.
TL;DR: The title system is a highly selective Fischer-Tropsch catalyst for the production of C(10)-C(20) hydrocarbons (diesel fuel) and its selectivity strongly depends on the mean size of the Ru nanoparticles.
Abstract: Diesel do nicely: The title system is a highly selective Fischer-Tropsch catalyst for the production of C(10)-C(20) hydrocarbons (diesel fuel). The C(10)-C(20) selectivity strongly depends on the mean size of the Ru nanoparticles. Nanoparticles with a mean size around 7 nm exhibit the highest C(10)-C(20) selectivity (ca. 65%) and a relatively higher turnover frequency for CO conversion.
TL;DR: A new fluorescence sensor for the highly selective detection of Cu2+ ion with a detection limit of 3.6 nM based on the aggregation-induced fluorescence quenching of the highly fluorescent glutathione-capped gold nanoparticles is reported.
TL;DR: As-prepared one-dimensional Pd nanostructures have a 5-fold twinned structure and can be further transformed into nanowires/nanorods with a smaller aspect ratio and finally to multiply twinned particles upon increasing the reaction time.
Abstract: In the presence of poly(vinylpyrrolidone) and I(-), uniform Pd nanowires and nanorods have been successfully prepared. As-prepared one-dimensional Pd nanostructures have a 5-fold twinned structure. The twinned Pd nanowires can be further transformed into nanowires/nanorods with a smaller aspect ratio and finally to multiply twinned particles upon increasing the reaction time. With structural anisotropy, the one-dimensional Pd nanostructures exhibit different chemical reactivities on their tips and sides.
TL;DR: Program for Changjiang Scholars and Innovative Research Team in University, China and Science-Technology Project of Fujian Provence, China.
TL;DR: In this paper, a hopping model is derived that not only quantitatively describes the charge mobility but also explains the observed band-like behavior of the electronic transport in organic materials, in contradiction to the Marcus electron transfer theory.
Abstract: The mechanism of charge transport in organic materials is still controversial from both experimental and theoretical perspectives. At room temperature, molecular deformations interact strongly with the charge carrier both through intermolecular and intramolecular phonons, suggesting a thermally activated hopping mechanism as described by the Marcus electron transfer theory. However, several experimental measurements have indicated that the electronic transport behaves in a ``bandlike'' manner, as indicated by a decrease in mobility with increasing temperature, in contradiction to the Marcus description. Bandlike first-principles calculations based on the Holstein-Peierls model tend to overestimate the charge mobility by about 2 orders of magnitude. Here, a hopping model is derived that not only quantitatively describes the charge mobility but also explains the observed bandlike behavior. This model uses the quantum version of charge-transfer theory coupled with a random-walk simulation of charge diffusion. The results bridge the gap between the two extreme mechanisms. This first-principles method predicts the room-temperature hole mobilities to be 2.4, 2.0, and $0.67\text{ }{\text{cm}}^{2}/\text{V}\text{ }\text{s}$, for rubrene, pentacene, and tetracene, respectively, in good agreement with experiment.
TL;DR: This Review focuses on recent work on stabilization of non-IPR fullerenes, including theoretical and empirical principles, experimental methods, and molecular structures of fused-pentagon fullererenes characterized so far.
Abstract: The most stable fullerenes obey the isolated-pentagon rule (IPR): hexagons of carbon atoms entirely surround pentagons to minimize strain. Recently, some examples of fused-pentagon fullerenes have been reported and this Review summarizes current work to stabilize non-IPR fullerenes.
The isolated pentagon rule (IPR) is now widely accepted as a general rule for determining the stability of all-carbon fullerene cages composed of hexagons and pentagons. Fullerenes that violate this rule have been deemed too reactive to be synthesized. The stabilization of non-IPR endohedral fullerenes depends on charge transfer from the encapsulated metal clusters (endoclusters) to fullerene cages, the electronic properties of empty all-carbon cages, the matching size and geometries of fullerene and endocluster, as well as the strong coordination of the metal ions to fused pentagons. The stability of non-IPR exohedral fullerenes can be rationalized primarily by both the 'strain-relief' and 'local-aromaticity' principles. This Review focuses on recent work on stabilization of non-IPR fullerenes, including theoretical and empirical principles, experimental methods, and molecular structures of fused-pentagon fullerenes characterized so far. The special chemical properties of non-IPR fullerenes that distinguish them from IPR-satisfying ones are also emphasized.
TL;DR: This work presents a novel approach for preparing TiO(2) nanotube array photocatalyst loaded with highly dispersed Ag nanoparticles through an ultrasound aided photochemical route and showed that Ag loading significantly enhanced the photocurrent and photocatalytic degradation rate of TiO (2)nanotube arrays under UV-light irradiation.
TL;DR: Wang et al. as mentioned in this paper compared the distribution and areas of existing mangroves among selected provinces of China, discussed the issues associated with mangrove conservation and restoration and highlighted major progress on research conducted by key institutions or universities in mainland China, Hong Kong, Taiwan and Macao.
Abstract: Aims In this paper, we highlighted some key progresses in mangrove conservation, restoration and research in China during last two decades. Methods Based on intensive literature review, we compared the distribution and areas of existing mangroves among selected provinces of China, discussed the issues associated with mangrove conservation and restoration and highlighted major progresses on mangrove research conducted by key institutions or universities in mainland China, Hong Kong, Taiwan and Macao. Important findings The population boom and rapid economic developments have greatly reduced mangrove areas in China since 1980s, leaving only 22 700 ha mangroves in mainland China in 2001. Chinese government has launched a series of programs to protect mangroves since 1980s and has established mangrove ecosystems as high-priority areas for improving environmental and living resource management. During last three decades, a total of 34 natural mangrove conservation areas have been established, which accounts for 80% of the total existing mangroves areas in China. Mangrove restoration areas in Mainland China accounted for <7% of the total mangroves areas in 2002. A great deal of research papers on Chinese mangroves has been published in international journals. However, more systematic protection strategies and active restoration measurements are still urgently needed in order to preserve these valuable resources in China.
TL;DR: The fact that the rank reversal phenomenon occurs not only in the AHP but also in many other decision making approaches such as the Borda-Kendall method for aggregating ordinal preferences, the simple additive weighting method, the technique for order preference by similarity to ideal solution (TOPSIS) method, and the cross-efficiency evaluation method in data envelopment analysis (DEA).
TL;DR: Novel concave Pd nanocrystals with uniform diameter were successfully prepared in the presence of formaldehyde to demonstrate the tunable degree of concavity and the percentage of {110} of the nanocry crystals are tunable by varying the amount offormaldehyde and the reaction temperature.
Abstract: Novel concave Pd nanocrystals with uniform diameter were successfully prepared in the presence of formaldehyde. While the outer surfaces of the as-prepared concave Pd nanocrystals are {111}, the faces concave toward the polyhedral center are high-surface-energy {110} faces. The degree of concavity and therefore the percentage of {110} of the nanocrystals are tunable by varying the amount of formaldehyde and the reaction temperature. Owing to the existence of active {110} facets, the electrocatalytic activity of the concave Pd nanocrystals displays dependency on their degree of concavity.
TL;DR: This paper aims to demonstrate the efforts towards in-situ applicability of EMMARM, which aims to provide real-time information about the physical properties of EMT and its applications in the natural environment.
Abstract: National Basic Research Program of China [2009CB421207]; National Natural Science Foundation of China [40930846, 40676063]
TL;DR: In this paper, the authors examined some practical numerical methods to solve a class of initial-boundary value problems for the fractional Fokker-Planck equation on a finite domain.
TL;DR: In this article, a general density function based on the maximum entropy (ME) approach was proposed to model the asymmetry in financial data, taking account of asymmetry, excess kurtosis, and high peakedness.