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Institution

Xiamen University

EducationAmoy, Fujian, China
About: Xiamen University is a education organization based out in Amoy, Fujian, China. It is known for research contribution in the topics: Catalysis & Population. The organization has 50472 authors who have published 54480 publications receiving 1058239 citations. The organization is also known as: Amoy University & Xiàmén Dàxué.


Papers
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Journal ArticleDOI
Xiaoliang Fang1, Cheng Chen1, Zhaohui Liu1, Pengxin Liu1, Nanfeng Zheng1 
TL;DR: It is demonstrated that cationic surfactant plays critical roles in forming the hollow mesoporous structure and can be extended as a general strategy to transform silica-coated composite materials into yolk-shell structures with either wormhole-like or oriented mesoporus shell.
Abstract: Hollow mesoporous silica spheres have recently attracted increasing attention. However, effective synthesis of uniform hollow mesoporous spheres with controllable well-defined pore structures for fundamental research and practical applications has remained a significant challenge. In this work, a straightforward and effective “cationic surfactant assisted selective etching” synthetic strategy was developed for the preparation of high-quality hollow mesoporous silica spheres with either wormhole-like or oriented mesoporous shell. The as-prepared hollow mesoporous silica spheres have large surface area, high pore volume, and controllable structure parameters. Our experiments demonstrated that cationic surfactant plays critical roles in forming the hollow mesoporous structure. A formation mechanism involving the etching of solid SiO2 accelerated by cationic surfactant followed by the redeposition of dissolved silica species directed by cationic surfactant is proposed. Furthermore, the strategy can be extended as a general strategy to transform silica-coated composite materials into yolk-shell structures with either wormhole-like or oriented mesoporous shell.

298 citations

Journal ArticleDOI
TL;DR: In this paper, a uniform and TiO2 nanoparticle coating on steels has been prepared using sol-gel method and hydrothermal post-treatments, and the morphology and structure of the coatings were analysed using atomic force microscopy and X-ray diffraction.

297 citations

Journal ArticleDOI
TL;DR: These findings identify a clinically actionable, epigenetic cause of cetuximab resistance, and describe a double-negative feedback loop between MIR100HG and the transcription factor GATA6, whereby Gata6 represses MIR 100HG, but this repression is relieved by miR-125b targeting of GATA 6.
Abstract: De novo and acquired resistance, which are largely attributed to genetic alterations, are barriers to effective anti-epidermal-growth-factor-receptor (EGFR) therapy. To generate cetuximab-resistant cells, we exposed cetuximab-sensitive colorectal cancer cells to cetuximab in three-dimensional culture. Using whole-exome sequencing and transcriptional profiling, we found that the long non-coding RNA MIR100HG and two embedded microRNAs, miR-100 and miR-125b, were overexpressed in the absence of known genetic events linked to cetuximab resistance. MIR100HG, miR-100 and miR-125b overexpression was also observed in cetuximab-resistant colorectal cancer and head and neck squamous cell cancer cell lines and in tumors from colorectal cancer patients that progressed on cetuximab. miR-100 and miR-125b coordinately repressed five Wnt/β-catenin negative regulators, resulting in increased Wnt signaling, and Wnt inhibition in cetuximab-resistant cells restored cetuximab responsiveness. Our results describe a double-negative feedback loop between MIR100HG and the transcription factor GATA6, whereby GATA6 represses MIR100HG, but this repression is relieved by miR-125b targeting of GATA6. These findings identify a clinically actionable, epigenetic cause of cetuximab resistance.

297 citations

Journal ArticleDOI
Christopher D. Whelan1, Christopher D. Whelan2, Andre Altmann3, Juan A. Botía4, Neda Jahanshad2, Derrek P. Hibar2, Julie Absil5, Saud Alhusaini1, Saud Alhusaini6, Marina K. M. Alvim7, Pia Auvinen8, Emanuele Bartolini9, Felipe P. G. Bergo7, Tauana Bernardes7, Karen Blackmon10, Karen Blackmon11, Barbara Braga7, Maria Eugenia Caligiuri12, Anna Calvo, Sarah J. A. Carr13, Jian Chen14, Shuai Chen15, Andrea Cherubini12, Philippe David5, Martin Domin16, Sonya Foley17, Wendy Franca7, Gerrit Haaker18, Dmitry Isaev2, Simon S. Keller19, Raviteja Kotikalapudi20, Magdalena A. Kowalczyk21, Ruben Kuzniecky11, Soenke Langner16, Matteo Lenge9, Kelly M. Leyden22, Min Liu6, Richard Q. Loi22, Pascal Martin20, Mario Mascalchi23, Mario Mascalchi9, Marcia Elisabete Morita7, Jose C. Pariente, Raúl Rodríguez-Cruces24, Christian Rummel25, Taavi Saavalainen8, Mira Semmelroch21, Mariasavina Severino26, Rhys H. Thomas17, Rhys H. Thomas27, Manuela Tondelli28, Domenico Tortora26, Anna Elisabetta Vaudano28, Lucy Vivash29, Lucy Vivash30, Felix von Podewils16, Jan Wagner31, Jan Wagner32, Bernd Weber32, Yi Yao15, Clarissa L. Yasuda7, Guohao Zhang33, Núria Bargalló, Benjamin Bender20, Neda Bernasconi6, Andrea Bernasconi6, Boris C. Bernhardt6, Ingmar Blümcke18, Chad Carlson11, Chad Carlson34, Gianpiero L. Cavalleri1, Fernando Cendes7, Luis Concha24, Norman Delanty1, Norman Delanty35, Chantal Depondt5, Orrin Devinsky11, Colin P. Doherty1, Niels K. Focke20, Antonio Gambardella12, Renzo Guerrini9, Khalid Hamandi27, Khalid Hamandi17, Graeme D. Jackson30, Graeme D. Jackson21, Reetta Kälviäinen8, Peter Kochunov36, Patrick Kwan29, Angelo Labate12, Carrie R. McDonald22, Stefano Meletti28, Terence J. O'Brien29, Terence J. O'Brien30, Sebastien Ourselin3, Mark P. Richardson37, Mark P. Richardson13, Pasquale Striano38, Thomas Thesen11, Thomas Thesen10, Roland Wiest25, Junsong Zhang15, Annamaria Vezzani39, Mina Ryten4, Mina Ryten13, Paul M. Thompson2, Sanjay M. Sisodiya4 
01 Feb 2018-Brain
TL;DR: In the largest neuroimaging study to date, Whelan and colleagues report robust structural alterations across and within epilepsy syndromes, including shared volume loss in the thalamus, and widespread cortical thickness differences.
Abstract: Progressive functional decline in the epilepsies is largely unexplained. We formed the ENIGMA-Epilepsy consortium to understand factors that influence brain measures in epilepsy, pooling data from 24 research centres in 14 countries across Europe, North and South America, Asia, and Australia. Structural brain measures were extracted from MRI brain scans across 2149 individuals with epilepsy, divided into four epilepsy subgroups including idiopathic generalized epilepsies (n =367), mesial temporal lobe epilepsies with hippocampal sclerosis (MTLE; left, n = 415; right, n = 339), and all other epilepsies in aggregate (n = 1026), and compared to 1727 matched healthy controls. We ranked brain structures in order of greatest differences between patients and controls, by meta-analysing effect sizes across 16 subcortical and 68 cortical brain regions. We also tested effects of duration of disease, age at onset, and age-by-diagnosis interactions on structural measures. We observed widespread patterns of altered subcortical volume and reduced cortical grey matter thickness. Compared to controls, all epilepsy groups showed lower volume in the right thalamus (Cohen's d = -0.24 to -0.73; P < 1.49 × 10-4), and lower thickness in the precentral gyri bilaterally (d = -0.34 to -0.52; P < 4.31 × 10-6). Both MTLE subgroups showed profound volume reduction in the ipsilateral hippocampus (d = -1.73 to -1.91, P < 1.4 × 10-19), and lower thickness in extrahippocampal cortical regions, including the precentral and paracentral gyri, compared to controls (d = -0.36 to -0.52; P < 1.49 × 10-4). Thickness differences of the ipsilateral temporopolar, parahippocampal, entorhinal, and fusiform gyri, contralateral pars triangularis, and bilateral precuneus, superior frontal and caudal middle frontal gyri were observed in left, but not right, MTLE (d = -0.29 to -0.54; P < 1.49 × 10-4). Contrastingly, thickness differences of the ipsilateral pars opercularis, and contralateral transverse temporal gyrus, were observed in right, but not left, MTLE (d = -0.27 to -0.51; P < 1.49 × 10-4). Lower subcortical volume and cortical thickness associated with a longer duration of epilepsy in the all-epilepsies, all-other-epilepsies, and right MTLE groups (beta, b < -0.0018; P < 1.49 × 10-4). In the largest neuroimaging study of epilepsy to date, we provide information on the common epilepsies that could not be realistically acquired in any other way. Our study provides a robust ranking of brain measures that can be further targeted for study in genetic and neuropathological studies. This worldwide initiative identifies patterns of shared grey matter reduction across epilepsy syndromes, and distinctive abnormalities between epilepsy syndromes, which inform our understanding of epilepsy as a network disorder, and indicate that certain epilepsy syndromes involve more widespread structural compromise than previously assumed.

296 citations

Journal ArticleDOI
TL;DR: The idea of the importance of mounting an inflammatory response for effective immunity is supported by a multiplicity of experimental data and it is also well understood that resolution of inflammation is essential for maintaining the balance between health and disease as mentioned in this paper.
Abstract: The idea of the importance of mounting an inflammatory response for effective immunity is supported by a multiplicity of experimental data. It is also well understood that resolution of inflammation is essential for maintaining the balance between health and disease. When the normal regulatory mechanisms are disturbed, the potential for developing chronic inflammatory diseases is increased. Inflammation is a key element in the response of the innate immune system to a variety of challenges, including those provided by bacterial and viral infection as well as by damaged or dying host cells. Here we review elements of innate immunity that lead to inflammation and some of the host mechanisms that allow for the resolution of the inflammatory responses.

296 citations


Authors

Showing all 50945 results

NameH-indexPapersCitations
Zhong Lin Wang2452529259003
Lei Jiang1702244135205
Yang Gao1682047146301
William A. Goddard1511653123322
Rui Zhang1512625107917
Xiaoyuan Chen14999489870
Fuqiang Wang145151895014
Galen D. Stucky144958101796
Shu-Hong Yu14479970853
Wei Huang139241793522
Bin Liu138218187085
Jie Liu131153168891
Han Zhang13097058863
Lei Zhang130231286950
Jian Zhou128300791402
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
2023248
2022942
20216,782
20205,710
20194,982
20184,057