Showing papers by "Yahoo! published in 1995"
TL;DR: Evidence is provided that GSH is a promising drug for the prevention of oxaliplatin-induced neuropathy, and that it does not reduce the clinical activity of oxaloplatin.
Abstract: PURPOSE: We performed a randomized, double-blind, placebo-controlled trial to assess the efficacy of glutathione (GSH) in the prevention of oxaliplatin-induced neurotoxicity. PATIENTS AND METHODS: Fifty-two patients treated with a bimonthly oxaliplatin-based regimen were randomized to receive GSH (1,500 mg/m2 over a 15-minute infusion period before oxaliplatin) or normal saline solution. Clinical neurologic evaluation and electrophysiologic investigations were performed at baseline and after four (oxaliplatin dose, 400 mg/m2), eight (oxaliplatin dose, 800 mg/m2), and 12 (oxaliplatin dose, 1,200 mg/m2) cycles of treatment. RESULTS: At the fourth cycle, seven patients showed clinically evident neuropathy in the GSH arm, whereas 11 patients in the placebo arm did. After the eighth cycle, nine of 21 assessable patients in the GSH arm suffered from neurotoxicity compared with 15 of 19 in the placebo arm. With regard to grade 2 to 4 National Cancer Institute common toxicity criteria, 11 patients experienced neu...
389 citations
Patent•
28 Aug 1995TL;DR: In this article, the authors propose a method for searching for a desired data item within a group of data, where representative samples among a set of data to be searched are displayed, and two representative samples in display are selected to specify a new area of data.
Abstract: The invention relates to searching for a desired data item within a group of data. Representative samples among a group of data to be searched are displayed, and two representative samples in display are selected to specify a new area of data to be searched. Thus, the portion of the data is bracketed and narrowed down, and the desired data item is found quickly and efficiently.
4 citations