Showing papers by "Yahoo! published in 2004"

Combating web spam with trustrank

Abstract: Web spam pages use various techniques to achieve higher-than-deserved rankings in a search engine's results. While human experts can identify spam, it is too expensive to manually evaluate a large number of pages. Instead, we propose techniques to semi-automatically separate reputable, good pages from spam. We first select a small set of seed pages to be evaluated by an expert. Once we manually identify the reputable seed pages, we use the link structure of the web to discover other pages that are likely to be good. In this paper we discuss possible ways to implement the seed selection and the discovery of good pages. We present results of experiments run on the World Wide Web indexed by AltaVista and evaluate the performance of our techniques. Our results show that we can effectively filter out spam from a significant fraction of the web, based on a good seed set of less than 200 sites.

Understanding user goals in web search

Abstract: Previous work on understanding user web search behavior has focused on how people search and what they are searching for, but not why they are searching. In this paper, we describe a framework for understanding the underlying goals of user searches, and our experience in using the framework to manually classify queries from a web search engine. Our analysis suggests that so-called navigational" searches are less prevalent than generally believed while a previously unexplored "resource-seeking" goal may account for a large fraction of web searches. We also illustrate how this knowledge of user search goals might be used to improve future web search engines.

Method and system for customizing views of information associated with a social network user

Abstract: A method, apparatus, and system are directed towards managing a view of a social network user's personal information based, in part, on user-defined criteria. The user-defined criteria may be applied towards a user's relationship with each prospective viewer. The user-defined criteria may include degrees of separation between members of the social network, a relationship to the prospective viewer, as well as criteria based, in part, on activities, such as dating, employment, hobbies, and the like. The user-defined criteria may also be based on a group membership, a strength of a relationship, and the like. Such user-defined relationship criteria may then be mapped against various categories of information associated with social network user to provide customized views of the social network user.

System and method of information filtering using measures of affinity of a relationship

Abstract: A system, apparatus, and method are directed towards enabling information filtering using measures of an affinity of a relationship between subscribers of an online portal system. The affinity of a relationship may be determined based, in part, on the tracking of various online behaviors of and between subscribers of the portal system. Any of a variety of behaviors may be tracked, including message communications between subscribers, participation in instant messaging groups, purchases, activities, categories, and so forth. Such behaviors may be employed to determine a level of trust (or affinity) between subscribers of the portal system. This affinity measurement may be used to filter various information, including, but not limited to, product recommendations, ratings, polling queries, advertising, social network communications, personal ads, search results, and the like. Moreover, this affinity measurement may also be employed to perform message spam detection.

Bovine tuberculosis: an old disease but a new threat to Africa.

Abstract: Bovine tuberculosis (TB) is a disease characterised by progressive development of specific granulomatous lesions or tubercles in lung tissue, lymph nodes or other organs. Mycobacterium bovis is the causative agent of the disease. Bovine species, including bison and buffaloes, are susceptible to the disease, but nearly all warm-blooded animals can be affected. All species are not equally susceptible to the disease; some are spill-over (end) hosts and others maintenance hosts. In Africa, bovine TB primarily affects cattle; however, infection in other farm and domestic animals, such as sheep, goats, pigs, dogs and cats, is not uncommon. Wild ruminants and carnivores are also affected and are the natural reservoirs of the infectious agent in the wild. Man is also susceptible to the disease, the highest risk groups being individuals with concomitant HIV/AIDS infection. In Africa, human TB is widely known to be caused by M. tuberculosis; however, an unknown proportion of cases are due to M. bovis. This infection in humans is under-reported as a result of the diagnostic limitations of many laboratories in distinguishing M. bovis from M. tuberculosis. None of the national reports submitted to the OIE and WHO by African member states mention the importance of M. bovis in human TB cases. Consumption of unpasteurised milk and poorly heat-treated meat and close contact with infected animals represent the main sources of infection for humans. This review attempts to examine the impact of bovine TB on the health of animals and humans.

Crafting Information Technology Governance

Abstract: Information Technology (IT) governance has emerged as a fundamental business imperative, and rightfully so, because it is key to realizing IT business value. IT governance describes the distribution of IT decision-making rights and responsibilities among different stakeholders in the enterprise, and defines the procedures and mechanisms for making and monitoring strategic IT decisions. This article presents a holistic view of IT governance, in which structural, process, and relational capabilities are an integral part of an effective IT governance architecture. the article concludes with an IT Governance Assessment Process (ITGAP) model, with which business and IT executives can assess the effectiveness of their company's current IT governance architecture.

Spatial and temporal variations in precipitation in the Upper Indus Basin, global teleconnections and hydrological implications

Abstract: . Most of the flow in the River Indus from its upper mountain basin is derived from melting snow and glaciers. Climatic variability and change of both precipitation and energy inputs will, therefore, affect rural livelihoods at both a local and a regional scale through effects on summer runoff in the River Indus. Spatial variation in precipitation has been investigated by correlation and regression analysis of long-period records. There is a strong positive correlation between winter precipitation at stations over the entire region, so that, for practical forecasting of summer runoff in some basins, a single valley-floor precipitation station can be used In contrast, spatial relationships in seasonal precipitation are weaker in summer and sometimes significantly negative between stations north and south of the Himalayan divide. Although analysis of long datasets of precipitation from 1895 shows no significant trend, from 1961–1999 there are statistically significant increases in winter, in summer and in the annual precipitation at several stations. Preliminary analysis has identified a significant positive correlation between the winter North Atlantic Oscillation (NAO) and winter precipitation in the Karakoram and a negative correlation between NAO and summer rainfall at some stations. Keywords: upper Indus basin, climate change, time series analysis, spatial correlation, teleconnections

Graph Clustering and Minimum Cut Trees

Abstract: In this paper, we introduce simple graph clustering methods based on minimum cuts within the graph. The clustering methods are general enough to apply to any kind of graph but are well suited for graphs where the link structure implies a notion of reference, similarity, or endorsement, such as web and citation graphs. We show that the quality of the produced clusters is bounded by strong minimum cut and expansion criteria. We also develop a framework for hierarchical clustering and present applications to real-world data. We conclude that the clustering algorithms satisfy strong theoretical criteria and perform well in practice.

Method and system for seeding online social network contacts

Abstract: A method, apparatus, and system are directed towards seeding a user's contacts for their online social network. The invention is arranged to automatically recommend to the user a set of seed contacts that the user may employ to invite to join their social network. The set of seed contacts may be harvested from the user's existing portal activities, as well as other sources. In one embodiment, the invention analyzes portal activity, such as email exchanges with the user, and the like, to determine a frequency of contact with the user. Other sources may include but not be limited to emails, names within an address book of the user, names within an address book of another person, a buddy list, an instant messaging list, an activity, a mailing list, an online discussion group, a membership in a category, chat group, and the like.

Prospective Study of Tnf Blockade with Infliximab in Anti-Neutrophil Cytoplasmic Antibody-Associated Systemic Vasculitis

Abstract: . Tumor necrosis factor α (TNFα) plays an important role in the pathogenesis of anti-neutrophil cytoplasmic antibody-associated systemic vasculitis. TNFα blockade is a potential therapy for these disorders. Methods: An open-label, multi-center, prospective clinical trial in two subgroups was performed. Study I examined acute disease, either first presentation or relapse (Birmingham Vasculitis Activity Score [BVAS] ≥ 10; n = 16); study II examined persistent disease (BVAS ≥ 4; n = 16). Patients received infliximab (5 mg/kg) at 0, 2, 6, and 10 wk. Concomitant therapy in study I included prednisolone and cyclophosphamide. Study II patients continued their existing treatment regimens, with prednisolone tapered according to clinical status. Results: Mean age was 52.4 yr, 53% of the patients were female, and follow-up was 16.8 mo. Twenty-eight patients (88%) achieved remission (14 per study group). BVAS decreased from 12.3 (confidence interval [CI] = 10.5 to 14.0) at entry to 0.3 (CI = 0.2 to 0.9) at wk 14 ( P P = 0.001). Mean prednisolone dose (mg/d) in study II decreased from 23.8 (CI = 15.0 to 32.5) at entry to 8.8 (CI = 5.9 to 11.7) at wk 14 ( P = 0.002). There were two deaths and seven serious infections. Relapse occurred in five patients (three in study II) after a mean of 27 wk. Conclusion: TNFα blockade with infliximab was effective at inducing remission in 88% of patients with antibody-associated systemic vasculitis and permitted reduction in steroid doses. Severe infections were seen in 21% of patients, and despite continued infliximab, 20% of initial responders experienced disease flares. Infliximab is a promising new therapy for vasculitis both as a component of initial therapy and in the management of refractory disease. These results need confirmation in larger randomized trials.

Systems and methods for implementing person-to-person money exchange

Abstract: Systems and methods for effecting online financial transactions between individuals or between individuals and entities such as banks, merchants and other companies. Each user accesses a fund exchange server to establish an online account, which is used to transfer funds to and from other entities' online accounts. To fund an online account, funds can be transferred to the online account from a credit card account or from another online account. To withdraw funds, money can be transferred to a credit card account or other bank account. Any user may initiate a send money transaction or a request payment transaction with any other entity provided that entity has an e-mail address. For a send money transaction, the user sending money (payor) enters an amount of funds to be transferred and an e-mail address of the recipient of the funds (payee). The system sends an e-mail message to the payee at the address provided indicating that the amount of funds has been “received” on the payee's behalf. The payee must then either open an online account or identify an existing online account to complete the transaction. For a request money transaction, a user enters an amount of funds owed and an e-mail address for the recipient of the payment request (payor), and the system sends a payment request to the payor via e-mail at the provided address. If the payor accepts the payment request, the payor identifies an online account from which to transfer funds to the payee (initiator of the payment request). If the payor does not have an online account established, the payor must sign up for an online account and provide a credit card number to fund the online account. Thereafter, the amount of funds are transferred to the payee and the system sends an e-mail notification to the payee indicating that the funds have been “received” on the payee's behalf. In both cases, to complete a transaction, the payee must direct the received funds to an online account, for example, by providing an online account number and/or other identifying information such as a password. The payor may cancel the transaction at any time until the payee directs the received funds to an online account.

Systems and methods for search query processing using trend analysis

Abstract: Systems and methods for processing search requests include analyzing received queries in order to provide a more sophisticated understanding of the information being sought. In one embodiment, queries are parsed into units, which may comprise one or more words or tokens of the query, and the units are related in concept networks. Trend analysis is performed by sorting the queries into subsets along a dimension of interest and comparing concept networks for different subsets. Trend information is usable to enhance a response of an automated search agent to a subsequently received query.

Systems and methods for generating concept units from search queries

Abstract: Systems and method for enhancing search functionality provided to a user. In certain aspects, a query processing engine automatically decomposes queries into constituent units that are related to concepts in which a user may be interested. The query processing engine decomposes queries into one or more constituent units per query using statistical methods. In certain aspects, no real world knowledge is used in determining units. In other aspects, aspects of world and content knowledge are introduced to enhance and optimize performance, for example, manually using a team of one or more information engineers.

Immunology of tuberculosis.

Abstract: Tuberculosis is a major health problem throughout the world causing large number of deaths, more than that from any other single infectious disease. The review attempts to summarize the information available on host immune response to Mycobacterium tuberculosis. Since the main route of entry of the causative agent is the respiratory route, alveolar macrophages are the important cell types, which combat the pathogen. Various aspects of macrophage-mycobacterium interactions and the role of macrophage in host response such as binding of M. tuberculosis to macrophages via surface receptors, phagosome-lysosome fusion, mycobacterial growth inhibition/killing through free radical based mechanisms such as reactive oxygen and nitrogen intermediates; cytokine-mediated mechanisms; recruitment of accessory immune cells for local inflammatory response and presentation of antigens to T cells for development of acquired immunity have been described. The role of macrophage apoptosis in containing the growth of the bacilli is also discussed. The role of other components of innate immune response such as natural resistance associated macrophage protein (Nramp), neutrophils, and natural killer cells has been discussed. The specific acquired immune response through CD4 T cells, mainly responsible for protective Th1 cytokines and through CD8 cells bringing about cytotoxicity, also has been described. The role of CD-1 restricted CD8(+) T cells and non-MHC restricted gamma/deltaT cells has been described although it is incompletely understood at the present time. Humoral immune response is seen though not implicated in protection. The value of cytokine therapy has also been reviewed. Influence of the host human leucocyte antigens (HLA) on the susceptibility to disease is discussed. Mycobacteria are endowed with mechanisms through which they can evade the onslaught of host defense response. These mechanisms are discussed including diminishing the ability of antigen presenting cells to present antigens to CD4(+) T cells; production of suppressive cytokines; escape from fused phagosomes and inducing T cell apoptosis. The review brings out the complexity of the host-pathogen interaction and underlines the importance of identifying the mechanisms involved in protection, in order to design vaccine strategies and find out surrogate markers to be measured as in vitro correlate of protective immunity.

Search processing with automatic categorization of queries

Abstract: Search results are processed using search requests, including analyzing received queries in order to provide a more sophisticated understanding of the information being sought. A concept network is generated from a set of queries by parsing the queries into units and defining various relationships between the units. From these concept networks, queries can be automatically categorized into categories, or more generally, can be associated with one or more nodes of a taxonomy. The categorization can be used to alter the search results or the presentation of the results to the user. As an example of alterations of search results or presentation, the presentation might include a list of “suggestions” for related search query terms. As other examples, the corpus searched might vary depending on the category or the ordering or selection of the results to present to the user might vary depending on the category. Categorization might be done using a learned set of query-node pairs where a pair maps a particular query to a particular node in the taxonomy. The learned set might be initialized from a manual indication of which queries go with which nodes and enhanced has more searches are performed. One method of enhancement involves tracking post-query click activity to identify how a category estimate of a query might have varied from an actual category for the query as evidenced by the category of the post-query click activity, e.g., a particular hits of the search results that the user selected following the query. Another method involved determining relationships between units in the form of clusters and using clustering to modify the query-node pairs.

Frozen shoulder: MR arthrographic findings.

Abstract: PURPOSE: To evaluate the magnetic resonance (MR) arthrographic findings in patients with frozen shoulder. MATERIALS AND METHODS: Preoperative MR arthrograms of 22 patients (six women, 16 men; mean age, 54.7 years) with frozen shoulder treated with arthroscopic capsulotomy were compared with arthrograms of 22 age- and sex-matched control subjects without frozen shoulder. The thickness of the coracohumeral ligament (CHL) and the joint capsule, as well as the volume of the axillary recess, were measured (Mann-Whitney test). Abnormalities in the CHL, subcoracoid fat, superior glenohumeral ligament, superior border of the subscapularis tendon, long biceps tendon, and subscapularis recess were analyzed in consensus by two blinded radiologists (χ2 test). RESULTS: Patients with frozen shoulder had a significantly thickened CHL (4.1 mm vs 2.7 mm in controls) and a thickened joint capsule in the rotator cuff interval (7.1 mm vs 4.5 mm; P < .001 for both comparisons, Mann-Whitney test) but not in the axillary recess...

TiVo: making show recommendations using a distributed collaborative filtering architecture

Abstract: We describe the TiVo television show collaborative recommendation system which has been fielded in over one million TiVo clients for four years. Over this install base, TiVo currently has approximately 100 million ratings by users over approximately 30,000 distinct TV shows and movies. TiVo uses an item-item (show to show) form of collaborative filtering which obviates the need to keep any persistent memory of each user's viewing preferences at the TiVo server. Taking advantage of TiVo's client-server architecture has produced a novel collaborative filtering system in which the server does a minimum of work and most work is delegated to the numerous clients. Nevertheless, the server-side processing is also highly scalable and parallelizable. Although we have not performed formal empirical evaluations of its accuracy, internal studies have shown its recommendations to be useful even for multiple user households. TiVo's architecture also allows for throttling of the server so if more server-side resources become available, more correlations can be computed on the server allowing TiVo to make recommendations for niche audiences.

Method and system of controlling a context menu

Abstract: An embodiment of the invention, for controlling a context menu, used with a Web page, wherein the Web page is divided into regions, can comprise downloading additional menu items that are not part of the context menu prior to download, and monitoring for when a user calls for a context menu. Upon detecting a context menu call, it is determined what region was selected by the user, and at least one of the additional menu is made available to the user as part of the context menu interface. At least one of the additional menu items is chosen based on the region selected by the user.

Arthrodesis of the knee.

Abstract: The most common indication for arthrodesis of the knee is an infection at the site of a total knee arthroplasty. Deficiencies in bone stock and poor bone apposition adversely affect the success of a knee arthrodesis. Arthrodesis of the knee can provide a stable, painless extremity for high-functioning patients who are able to walk. Patient function after arthrodesis of the knee is superior to that after above-the-knee amputation. Conversion of a solid knee fusion to a total knee arthroplasty has a substantial complication rate.

Total Hip Arthroplasty for Congenital Hip Disease

Abstract: Background: It is generally agreed that the clinical and radiographic results of total hip replacement performed for degenerative arthritis secondary to congenital hip disease vary depending on the severity of the anatomical abnormality. In this study, we report the mid-term and long-term clinical and radiographic results of total hip arthroplasty performed for each of the three different types of congenital hip disease. Methods: Between 1976 and 1994, the senior author performed 229 consecutive primary total hip arthroplasties in 168 patients with osteoarthritis secondary to congenital hip disease. Seventy-six hips were dysplastic, sixty-nine had a low dislocation, and eighty-four had a high dislocation. The Charnley low-friction technique was performed in 178 hips, and the so-called hybrid technique was performed in forty-six hips. Cementless arthroplasty was used in only five hips. Results: After a minimum of seven years of follow-up, the rates of revision of the acetabular components were 15% in the dysplastic hips, 21% in the hips with a low dislocation, and 14% in those with a high dislocation. The rates of revision of the femoral components were 14%, 14%, and 16%, respectively. Survivorship analysis predicted an overall rate of prosthetic survival at fifteen years of 88.8% ± 4.8% in the dysplastic hips, 73.9% ± 7.2% in the hips with a low dislocation, and 76.4% ± 8.1% in those with a high dislocation. Conclusions: An understanding of the anatomical abnormalities and the use of appropriate techniques and implants make total hip arthroplasty feasible for treatment of the three types of congenital hip disease. In patients with a low dislocation, the major technical problem is reconstruction of the natural acetabulum. In those with a high dislocation, the challenge is to place the acetabular component inside the reconstructed true acetabulum and to use an appropriate femoral implant in the hypoplastic narrow femoral diaphysis. Level of Evidence: Prognostic study, Level II-1 (retrospective study). See Instructions to Authors for a complete description of levels of evidence.

Managing mangroves in Bangladesh: A strategy analysis

Abstract: Bangladesh, favoured by a tropical climate, houses the world's largest stretch of mangroves forests (Sundarbans Reserved Forest) and plantations. Around half of the forests of the country occur in the coastal zone. People extract various goods and services from the mangroves. Nevertheless the mangrove forests are depleting. Although the extent of the Sundarbans forest has not changed much, its decline is of a qualitative nature. Mangrove plantations are increasing in area but they are losing growing stock. To arrest this, Bangladesh has adopted several strategies.The ‘Sustainable Ecosystem Management’ strategy has now been adopted instead of the ‘Sustained Yield Principle’. Biodiversity conservation and enhancement has been taken as a key management goal. A zoning system is being developed for both production and protection purposes. The government facilitates alternative income for the local people by generating activities for the communities which are dependent on the forest. Different non-governmental organizations collaborate with the government in reducing the local people's dependence on the forest. Coastal plantations are erected to protect people from cyclones and to make the land more suitable for habitation. Through this greening of the coastal belt tree plantation is encouraged in coastal villages. Coastal embankments are being planted and leased to poor settlers in exchange for routine maintenance of the embankments. Plantations on newly accreted mud flats help in stabilizing the land, which can later on be settled by victims of erosion elsewhere. These adopted management measures do not only contribute to forestry resource management but also to the social, environmental and economic wellbeing of the coastal communities. These efforts are at present being integrated into an Integrated Coastal Zone Management (ICZM) project.

111In-Labeled CD34+ Hematopoietic Progenitor Cells in a Rat Myocardial Infarction Model

Abstract: Transplantation of progenitor cells (PCs) has been shown to improve neovascularization and left ventricular function after myocardial ischemia. The fate of transplanted PCs has been monitored by fluorescence labeling or by genetic modifications introducing reporter genes. However, these techniques are limited by the need to kill the experimental animal. The aim of this study was to radiolabel CD34+ hematopoietic PCs (HPCs) with 111In-oxine and to evaluate the feasibility of this in vivo method for monitoring myocardial homing of transplanted cells in a rat myocardial infarction model. Methods: Human HPCs were isolated from mobilized peripheral blood and labeled with 111In-oxine. Labeled HPCs were injected into the cavity of the left ventricle in nude rats 24 h after induction of myocardial infarction (n = 4) or sham operation (n = 4). Scintigraphic images were acquired up to 96 h after HPC injection. After animals were killed, tissue samples of various organs were harvested to calculate tissue-specific activity and for immunostaining. Results: Labeling efficiency of HPCs was 32% ± 11%. According to trypan-blue staining, viability of radiolabeled HPCs was impaired by 30% after 48 and 96 h in comparison with unlabeled cells, whereas proliferation and differentiation of HPCs was nullified after 7 d, as assessed by colony-forming assays. After injection of HPCs, the specific activity ratio of heart to peripheral muscle tissue increased from 1.10 ± 0.32 in sham-operated rats to 2.47 ± 0.92 (P = 0.020) in infarcted rats. However, the overall radioactivity detected in the heart was only about 1%. A transient high lung uptake of 17% ± 6% was observed within the first hour after infusion of HPCs. At 24 h after injection, the initial lung activity had shifted toward liver, kidneys, and spleen, resulting in an increase of radioactivity in these organs from 37% ± 6% to 57% ± 5%. Conclusion: Radiolabeling with 111In-oxine is a feasible in vivo method for monitoring transplanted HPCs in a rat myocardial infarction model. The potential to detect differences in myocardial homing between infarcted and normal hearts suggests that this method may provide a noninvasive imaging approach for clinical trials using transplanted HPCs in patients. Our findings, however, also demonstrated a negative effect of 111In-oxine on cellular function, which resulted in complete impairment of HPC proliferation and differentiation. For future trials in stem cell imaging with 111In-oxine, therefore, it will be mandatory to carefully check for radiation-induced cell damage.

Comparative usability evaluation

Abstract: This paper reports on a study assessing the consistency of usability testing across organisations. Nine independent organisations evaluated the usability of the same website, Microsoft Hotmail. The results document a wide difference in selection and application of methodology, resources applied, and problems reported. The organizations reported 310 different usability problems. Only two problems were reported by six or more organizations, while 232 problems (75%) were uniquely reported, that is, no two teams reported the same problem. Some of the unique findings were classified as serious. Even the tasks used by most or all teams produced very different results - around 70% of the findings for each of these tasks were unique. Our main conclusion is that our simple assumption that we are all doing the same and getting the same results in a usability test is plainly wrong.

Atrial Fibrillation Originating From Persistent Left Superior Vena Cava

Abstract: Background— The left superior vena cava (LSVC) is the embryological precursor of the ligament of Marshall, which has been implicated in the initiation and maintenance of atrial fibrillation (AF). Rarely, the LSVC may persist and has been associated with some organized arrhythmias, though not with AF. We report 5 patients in whom the LSVC was a source of ectopy, initiating AF. Methods and Results— In 5 patients (4 men; age, 46±11 years) with symptomatic drug-refractory AF, ectopy from the LSVC resulting in AF was observed after pulmonary vein isolation. The ectopics were spontaneous in 2 and induced by isoproterenol in the others and preceded P-wave onset by 67±13 ms. During multielectrode or electroanatomic mapping, venous potentials were recorded circumferentially at the proximal LSVC near its junction with the coronary sinus (CS), but at the mid-LSVC level, they were recorded only on part of the circumference. The LSVC was electrically connected to the lateral left atrium (LA) and through the CS to the ...

The relationship between active ghrelin levels and human obesity involves alterations in resting energy expenditure.

Abstract: Ghrelin is a gastric hormone that exerts a stimulatory effect on appetite and fat accumulation. Ser(3) octanoylation is regarded as a prerequisite for ghrelin biological activity, although des-octanoylated forms may retain biological functions in vitro. Circulating ghrelin levels are usually low in obesity and in states of positive energy balance. Hence, the aim of our study was to analyze plasma active and serum total ghrelin levels in 20 obese (ages, 22-42 yr; body mass index, 41.3 +/- 1.1 kg/m(2)) and 20 lean subjects (ages, 22-43 yr; body mass index, 22.4 +/- 0.6 kg/m(2)) as well as their relationship to measures of glucose homeostasis, body fat, and resting energy expenditure (REE). The measured/predicted REE percentage ratio was calculated to subdivide groups into those with positive (> or = 100% ) and negative (<100%) ratio values. In obese patients, plasma active (180 +/- 18 vs. 411 +/- 57 pg/ml; P < 0.001) and serum total ghrelin levels (3650 +/- 408 vs. 5263 +/- 643 pg/ml; P < 0.05) were significantly lower when compared with lean subjects. Hence, ghrelin activity, defined as the proportion of active over total ghrelin levels, was similarly reduced in the obese state (6.1 +/- 0.9% vs. 8.4 +/- 1%; P < 0.05). There was a significant correlation between active and total ghrelin (r = 0.62; P < 0.001), and between total ghrelin and insulin (r = -0.53; P < 0.001) or insulin resistance using the homeostatis model of assessment-insulin resistance (r = -0.49; P < 0.001) approach. Significantly higher active ghrelin levels (214 +/- 22 vs. 159 +/- 30 pg/ml; P < 0.05) and ghrelin activity (8 +/- 1.7% vs. 4.9 +/- 0.9%; P < 0.05) were observed in patients with positive compared with negative measured/predicted REE ratio values. Our study shows that obesity is associated with an impairment of the entire ghrelin system. The observation that ghrelin is further decreased in cases of abnormal energy profit adds new evidence to the relationship between ghrelin activity and energy balance in obesity.

Vitamin C and vitamin E protect the rat testes from cadmium-induced reactive oxygen species.

Abstract: Cadmium is an environmental and industrial pollutant that affects the male reproductive system of humans and animals However, the mechanism of its adverse effect on Leydig cell steroidogenesis remains unknown The present study points to the possible involvement of oxidative stress in the suppression of steroidogenesis Cadmium administration caused an increase in reactive oxygen species (ROS) by elevating testicular malondialdehyde (MDA) and decreasing the activities of testicular antioxidant enzymes such as glutathione peroxidase and superoxide dismutase The mRNA of Steroid Acute Regulatory (StAR) protein was substantially reduced The activities of testicular delta5-3beta and 17-beta-hydroxysteroid dehydrogenases (HSD) as well as serum testosterone level were also lowered, suggesting that cadmium-induced ROS inhibit testicular steroidogenesis Supplementation with vitamin C (VC) and or vitamin E (VE) reduced testicular ROS and restored normal testicular function in Cd-exposed rats We conclude that VC and VE prevent oxidative stress and play vital roles in co-regulating StAR gene expression and steroid production in cadmium-exposed rats

Voice integrated VOIP system

Abstract: An integrated VoIP unified message processing system includes a voice platform that processes data in native VoIP format. There is no use of hardware telephone interface cards (TICs) or software transcoding to transform data to PCM or other formats. Cost reductions are achieved by the elimination of expensive dedicated hardware and scalability is achieved by obviating the need for software transcoding.