Showing papers by "Yonsei University published in 2007"

Artificially engineered magnetic nanoparticles for ultra-sensitive molecular imaging.

Abstract: Successful development of ultra-sensitive molecular imaging nanoprobes for the detection of targeted biological objects is a challenging task Although magnetic nanoprobes have the potential to perform such a role, the results from probes that are currently available have been far from optimal Here we used artificial engineering approaches to develop innovative magnetic nanoprobes, through a process that involved the systematic evaluation of the magnetic spin, size and type of spinel metal ferrites These magnetism-engineered iron oxide (MEIO) nanoprobes, when conjugated with antibodies, showed enhanced magnetic resonance imaging (MRI) sensitivity for the detection of cancer markers compared with probes currently available Also, we successfully visualized small tumors implanted in a mouse Such high-performance, nanotechnology-based molecular probes could enhance the ability to visualize other biological events critical to diagnostics and therapeutics

UV Star Formation Rates in the Local Universe

Abstract: We measure star formation rates (SFRs) of ≈50,000 optically selected galaxies in the local universe (z ≈ 0.1)—from gas-rich dwarfs to massive ellipticals. We obtain dust-corrected SFRs by fitting the GALEX (ultraviolet) and SDSS photometry to a library of dust-attenuated population synthesis models. For star-forming galaxies, our UV-based SFRs compare remarkably well with those from SDSS-measured emission lines (Hα). Deviations from perfect agreement are shown to be due to differences in the dust attenuation estimates. In contrast to Hα measurements, UV provides reliable SFRs for galaxies with weak Hα, and where Hα is contaminated with AGN emission (1/2 of the sample). Using full-SED SFRs, we calibrate a simple prescription that uses GALEX far- and near-UV magnitudes to produce dust-corrected SFRs for normal star-forming galaxies. The specific SFR is considered as a function of stellar mass for (1) star-forming galaxies with no AGNs, (2) those hosting an AGN, and (3) galaxies without Hα emission. We find that the three have distinct star formation histories, with AGNs lying intermediate between the star-forming and the quiescent galaxies. Star-forming galaxies without an AGN lie on a relatively narrow linear sequence. Remarkably, galaxies hosting a strong AGN appear to represent the massive continuation of this sequence. On the other hand, weak AGNs, while also massive, have lower SFRs, sometimes extending to the realm of quiescent galaxies. We propose an evolutionary sequence for massive galaxies that smoothly connects normal star-forming galaxies to quiescent galaxies via strong and weak AGNs. We confirm that some galaxies with no Hα show signs of star formation in the UV. We derive a cosmic star formation density at z = 0.1 with significantly smaller total error than previous measurements.

Differential antigen processing by dendritic cell subsets in vivo

Abstract: Dendritic cells (DCs) process and present self and foreign antigens to induce tolerance or immunity. In vitro models suggest that induction of immunity is controlled by regulating the presentation of antigen, but little is known about how DCs control antigen presentation in vivo. To examine antigen processing and presentation in vivo, we specifically targeted antigens to two major subsets of DCs by using chimeric monoclonal antibodies. Unlike CD8+ DCs that express the cell surface protein CD205, CD8- DCs, which are positive for the 33D1 antigen, are specialized for presentation on major histocompatibility complex (MHC) class II. This difference in antigen processing is intrinsic to the DC subsets and is associated with increased expression of proteins involved in MHC processing.

The calibration and data products of GALEX

Abstract: We describe the calibration status and data products pertaining to the GR2 and GR3 data releases of the Galaxy Evolution Explorer (GALEX). These releases have identical pipeline calibrations that are significantly improved over the GR1 data release. GALEX continues to survey the sky in the far-ultraviolet (FUV, ~154 nm) and near-ultraviolet (NUV, ~232 nm) bands, providing simultaneous imaging with a pair of photon-counting, microchannel plate, delay line readout detectors. These 1.25° field of view detectors are well suited to ultraviolet observations because of their excellent red rejection and negligible background. A dithered mode of observing and photon list output pose complex requirements on the data processing pipeline, entangling detector calibrations, and aspect reconstruction algorithms. Recent improvements have achieved photometric repeatability of 0.05 and 0.03 m_(AB) in the FUV and NUV, respectively. We have detected a long-term drift of order 1% FUV and 6% NUV over the mission. Astrometric precision is of order 0.5" rms in both bands. In this paper we provide the GALEX user with a broad overview of the calibration issues likely to be confronted in the current release. Improvements are likely as the GALEX mission continues into an extended phase with a healthy instrument, no consumables, and increased opportunities for guest investigations.

Superparamagnetic Colloids: Controlled Synthesis and Niche Applications**

Abstract: The aim of this article is to provide a comprehensive review of current research activities that center on superparamagnetic colloids. We begin with an overview of synthetic strategies that have been developed for generating both nanoscale and mesoscale superparamagnetic colloids, with a focus on those systems that can be prepared as monodisperse samples and in relatively large quantities. We then discuss a variety of techniques that have been exploited for modifying surface properties, as well as for controlling the assembly and patterning of these magnetically active colloids. Towards the end, we highlight a range of innovative applications enabled by the unique combination of superparamagnetism and colloidal suspension. We conclude this review article with personal remarks and perspectives on the directions toward which future research in this area might be directed.

The GALEX Ultraviolet Atlas of Nearby Galaxies

Abstract: We present images, integrated photometry, and surface-brightness and color profiles for a total of 1034 nearby galaxies recently observed by the Galaxy Evolution Explorer (GALEX) satellite in its far-ultraviolet (FUV; λ_(eff) = 1516 A) and near-ultraviolet (NUV; λ_(eff) = 2267 A) bands. Our catalog of objects is derived primarily from the GALEX Nearby Galaxies Survey (NGS) supplemented by galaxies larger than 1' in diameter serendipitously found in these fields and in other GALEX exposures of similar of greater depth. The sample analyzed here adequately describes the distribution and full range of properties (luminosity, color, star formation rate [SFR]) of galaxies in the local universe. From the surface brightness profiles obtained we have computed asymptotic magnitudes, colors, and luminosities, along with the concentration indices C31 and C42. We have also morphologically classified the UV surface brightness profiles according to their shape. This data set has been complemented with archival optical, near-infrared, and far-infrared fluxes and colors. We find that the integrated (FUV − K) color provides robust discrimination between elliptical and spiral/irregular galaxies and also among spiral galaxies of different subtypes. Elliptical galaxies with brighter K-band luminosities (i.e., more massive) are redder in (NUV − K) color but bluer in (FUV − NUV) (a color sensitive to the presence of a strong UV upturn) than less massive ellipticals. In the case of the spiral/irregular galaxies our analysis shows the presence of a relatively tight correlation between the (FUV − NUV) color (or, equivalently, the slope of the UV spectrum, β) and the total infrared-to-UV ratio. The correlation found between (FUV − NUV) color and K-band luminosity (with lower luminosity objects being bluer than more luminous ones) can be explained as due to an increase in the dust content with galaxy luminosity. The images in this Atlas along with the profiles and integrated properties are publicly available through a dedicated Web page.

Signaling Pathways Downstream of Pattern-Recognition Receptors and Their Cross Talk

Abstract: Pattern-recognition receptors (PRRs) initiate innate immunity through pathogen recognition. Serum PRRs opsonize pathogens for enhanced phagocytic clearance. Toll-like receptors (TLRs) initiate common NF-κB/AP-1 and distinct IRF3/7 pathways to coordinate innate immunity and to initiate adaptive immunity against diverse pathogens. Cytoplasmic caspase-recruiting domain (CARD) helicases, such as RIG-I/MDA5, mediate antiviral immunity by inducing the production of type I interferons via the adaptor IPS-1, whereas nucleotide-binding oligomerization domain (NOD)-like receptors mediate mainly antibacterial immunity by activating NF-κB or inflammasomes. Dectin-1 is important for antifungal immunity, promoting phagocytosis and activating NF-κB. Potentially harmful TLR signaling pathways can be negatively regulated by negative feedback mechanisms and also by anti-inflammatory factors such as TGFβ, interleukin (IL)-10, and steroids. Many combinations of TLR-TLR and TLR-NOD modulate inflammatory responses. TLR...

Observational evidence for AGN feedback in early-type galaxies

Abstract: The definitive version is available at www.blackwell-synergy.com. Copyright Blackwell Publishing

Building capabilities for international operations through networks: a study of Indian firms

Abstract: In this study we seek to explain how firms from emerging markets build capabilities to operate in international markets through learning from parental networks. The building of these capabilities is of particular interest, as firms from emerging markets may not necessarily possess the monopolistic advantages commonly referred to in IB literature, which allow a firm to succeed in international markets. Using lagged cross-sectional regression models on a sample of 794 Indian firms, we found that firms draw on the international experience of their parental and foreign networks to build such capabilities. Findings also indicate that network scope is beneficial for increasing exposure to international markets only in the case of networks that are either small or medium sized. Additionally, we found that firms lacking market power in their home market benefit through foreign partnerships when internationalizing operations.

A New Approach for Health Monitoring of Structures: Terrestrial Laser Scanning

Abstract: This paper presents a new approach for the health monitoring of structures using terrestrial laser scanning (TLS). 3-D coordinates of a target structure acquired using TLS can have maximum errors of about 10 mm, insufficient for health monitoring of structures. A displacement measurement model to improve the accuracy of the measurement is offered. The model is tested experimentally on a simply supported steel beam. Measurements were made using 3 different techniques: 1) linear variable displacement transducers (LVDTs), 2) electric strain gages, and 3) a long gage fiber optic sensor. The maximum deflections estimated by the TLS model are less than 1 mm and within 1.6% of those measured directly by LVDT. Although GPS methods allow measurement of displacements only at the GPS receiver antenna location, the proposed TLS method allows measurement of the entire bridge's deformed shape, and thus a realistic solution for monitoring structures at both structure and member level. Furthermore, it can be used to create a 3-D finite element model of a structural member or the entire structure at any point in time automatically. Through periodic measurement of deformations of a structure/structural member and performing inverse structural analyses with measured 3-D displacements, a structure's health can be monitored continuously.

Energy loss and flow of heavy quarks in Au+Au collisions at sNN=200GeV

Abstract: The PHENIX experiment at the BNL Relativistic Heavy Ion Collider (RHIC) has measured electrons with 0.3 < p(T) < 9 GeV/c at midrapidity (y < 0.35) from heavy-flavor (charm and bottom) decays in Au + Au collisions at root s(NN) = 200 GeV. The nuclear modification factor R-AA relative to p + p collisions shows a strong suppression in central Au + Au collisions, indicating substantial energy loss of heavy quarks in the medium produced at RHIC energies. A large azimuthal anisotropy v(2) with respect to the reaction plane is observed for 0.5 < p(T) < 5 GeV/c indicating substantial heavy-flavor elliptic flow. Both R-AA and v(2) show a p(T) dependence different from those of neutral pions. A comparison to transport models which simultaneously describe R-AA(p(T)) and v(2)(p(T)) suggests that the viscosity to entropy density ratio is close to the conjectured quantum lower bound, i.e., near a perfect fluid.

Overcoming artifacts from metallic orthopedic implants at high-field-strength MR imaging and multi-detector CT.

Abstract: At magnetic resonance (MR) imaging and multidetector computed tomography (CT), artifacts arising from metallic orthopedic hardware are an obstacle to obtaining optimal images. Although various techniques for reducing such artifacts have been developed and corroborated by previous researchers, a new era of more powerful MR imaging and multidetector CT modalities has renewed the importance of a systematic consideration of methods for artifact reduction. Knowledge of the factors that contribute to artifacts, of related theories, and of artifact reduction techniques has become mandatory for radiologists. Factors that affect artifacts on MR images include the composition of the metallic hardware, the orientation of the hardware in relation to the direction of the main magnetic field, the strength of the magnetic field, the pulse sequence type, and other MR imaging parameters (mainly voxel size, which is determined by the field of view, image matrix, section thickness, and echo train length). At multidetector CT, the factors that affect artifacts include the composition of the hardware, orientation of the hardware, acquisition parameters (peak voltage, tube charge, collimation, and acquired section thickness), and reconstruction parameters (reconstructed section thickness, reconstruction algorithm used, and whether an extended CT scale was used). A comparison of images obtained with different hardware and different acquisition and reconstruction parameters facilitates an understanding of methods for reducing or overcoming artifacts related to metallic implants.

J/psi production versus centrality, transverse momentum, and rapidity in Au+Au collisions at root S-NN=200 GeV

Abstract: The PHENIX experiment at the BNL Relativistic Heavy Ion Collider (RHIC) has measured J/psi production for rapidities -2.2 < y < 2.2 in Au+Au collisions at root s(NN)=200 GeV. The J/psi invariant yield and nuclear modification factor R-AA as a function of centrality, transverse momentum, and rapidity are reported. A suppression of J/psi relative to binary collision scaling of proton-proton reaction yields is observed. Models which describe the lower energy J/psi data at the CERN Super Proton Synchrotron invoking only J/psi destruction based on the local medium density predict a significantly larger suppression at RHIC and more suppression at midrapidity than at forward rapidity. Both trends are contradicted by our data.

Location-based recommendation system using Bayesian user's preference model in mobile devices

Abstract: As wireless communication advances, research on location-based services using mobile devices has attracted interest, which provides information and services related to user's physical location. As increasing information and services, it becomes difficult to find a proper service that reflects the individual preference at proper time. Due to the small screen of mobile devices and insufficiency of resources, personalized services and convenient user interface might be useful. In this paper, we propose a map-based personalized recommendation system which reflects user's preference modeled by Bayesian Networks (BN). The structure of BN is built by an expert while the parameter is learned from the dataset. The proposed system collects context information, location, time, weather, and user request from the mobile device and infers the most preferred item to provide an appropriate service by displaying onto the mini map.

The UV-Optical Galaxy Color-Magnitude Diagram. I. Basic Properties

Abstract: We have analyzed the bivariate distribution of galaxies as a function of ultraviolet-optical colors and absolute magnitudes in the local universe. The sample consists of galaxies with redshifts and optical photometry from the Sloan Digital Sky Survey (SDSS) main galaxy sample matched with detections in the near-ultraviolet (NUV) and far-ultraviolet (FUV) bands in the Medium Imaging Survey being carried out by the Galaxy Evolution Explorer (GALEX) satellite. In the (NUV − r)_(0.1) versus M_(r,0.1) galaxy color-magnitude diagram, the galaxies separate into two well-defined blue and red sequences. The (NUV − r)_(0.1) color distribution at each M_(r,0.1) is not well fit by the sum of two Gaussians due to an excess of galaxies in between the two sequences. The peaks of both sequences become redder with increasing luminosity, with a distinct blue peak visible up to M_(r,0.1) ~ − 23. The r_(0.1)-band luminosity functions vary systematically with color, with the faint-end slope and characteristic luminosity gradually increasing with color. After correcting for attenuation due to dust, we find that approximately one-quarter of the color variation along the blue sequence is due to dust, with the remainder due to star formation history and metallicity. Finally, we present the distribution of galaxies as a function of specific star formation rate and stellar mass. The specific star formation rates imply that galaxies along the blue sequence progress from low-mass galaxies with star formation rates that increase somewhat with time to more massive galaxies with a more or less constant star formation rate. Above a stellar mass of ~10^(10.5) M_☉, galaxies with low ratios of current to past averaged star formation rate begin to dominate.

Cdkn1a deletion improves stem cell function and lifespan of mice with dysfunctional telomeres without accelerating cancer formation

Abstract: Telomere shortening limits the proliferative lifespan of human cells by activation of DNA damage pathways, including upregulation of the cell cycle inhibitor p21 (encoded by Cdkn1a, also known as Cip1 and Waf1)) (refs. 1-5). Telomere shortening in response to mutation of the gene encoding telomerase is associated with impaired organ maintenance and shortened lifespan in humans and in mice. The in vivo function of p21 in the context of telomere dysfunction is unknown. Here we show that deletion of p21 prolongs the lifespan of telomerase-deficient mice with dysfunctional telomeres. p21 deletion improved hematolymphopoiesis and the maintenance of intestinal epithelia without rescuing telomere function. Moreover, deletion of p21 rescued proliferation of intestinal progenitor cells and improved the repopulation capacity and self-renewal of hematopoietic stem cells from mice with dysfunctional telomeres. In these mice, apoptotic responses remained intact, and p21 deletion did not accelerate chromosomal instability or cancer formation. This study provides experimental evidence that telomere dysfunction induces p21-dependent checkpoints in vivo that can limit longevity at the organismal level.

Behavioral and Emotional Problems Reported by Parents of Children Ages 6 to 16 in 31 Societies

Abstract: This study compared parents' ratings of behavioral and emotional problems on the Child Behavior Checklist (Achenbach, 1991;Achenbach & Rescorla, 2001) for general population samples of children age...

Testing the 8-syndrome structure of the child behavior checklist in 30 societies

Abstract: There is a growing need for multicultural collaboration in child mental health services, training, and research. To facilitate such collaboration, this study tested the 8-syndrome structure of the Child Behavior Checklist (CBCL) in 30 societies. Parents' CBCL ratings of 58,051 6- to 18-year-olds were subjected to confirmatory factor analyses, which were conducted separately for each society. Societies represented Asia; Africa; Australia; the Caribbean; Eastern, Western, Southern, and Northern Europe; the Middle East; and North America. Fit indices strongly supported the correlated 8-syndrome structure in each of 30 societies. The results support use of the syndromes in diverse societies.

A Search for Extended Ultraviolet Disk (XUV-Disk) Galaxies in the Local Universe

Abstract: We have initiated a search for extended ultraviolet disk (XUV-disk) galaxies in the local universe. Here we compare GALEX UV and visible-NIR images of 189 nearby (D < 40 Mpc) S0-Sm galaxies included in the GALEX Atlas of Nearby Galaxies and present the first catalog of XUV-disk galaxies. We find that XUV-disk galaxies are surprisingly common but have varied relative (UV/optical) extent and morphology. Type 1 objects (≳20% incidence) have structured, UV-bright/optically faint emission features in the outer disk, beyond the traditional star formation threshold. Type 2 XUV-disk galaxies (~10% incidence) exhibit an exceptionally large, UV-bright/optically low surface brightness (LSB) zone having blue UV-K_s outside the effective extent of the inner, older stellar population, but not reaching extreme galactocentric distance. If the activity occurring in XUV-disks is episodic, a higher fraction of present-day spirals could be influenced by such outer disk star formation. Type 1 disks are associated with spirals of all types, whereas Type 2 XUV-disks are predominantly found in late-type spirals. Type 2 XUV-disks are forming stars quickly enough to double their (currently low) stellar mass in the next Gyr (assuming a constant star formation rate). XUV-disk galaxies of both types are systematically more gas-rich than the general galaxy population. Minor external perturbation may stimulate XUV-disk incidence, at least for Type 1 objects. XUV-disks are the most actively evolving galaxies growing via inside-out disk formation in the current epoch, and may constitute a segment of the galaxy population experiencing significant, continued gas accretion from the intergalactic medium or neighboring objects.

Effect of Seed Layer on the Growth of ZnO Nanorods

Abstract: To investigate the effect of seed layer on the growth of ZnO nanorods during hydrothermal synthesis, different types of sputter-deposited ZnO films were used. The changes in growth rate, diameter, density, and surface area of highly oriented ZnO nanorods on each seed layer were examined. The growth rate of ZnO nanorods has a strong relationship with the intensity of (0001) orientation. The density of nanorods per unit area is larger if the diameter of the nanorods is smaller. The total surface area of ZnO nanorods is determined by the growth rate and density per unit area. It was found that the morphology of the ZnO nanorods is strongly influenced by the thickness of the seed layer and the corresponding crystal size. A thinner ZnO seed layer provides a higher surface area of ZnO nanorods because of the smaller crystal size of the seed layer. The orientation of the ZnO seed layer significantly affects the crystallinity of the nanorods.