Yonsei University

About: Yonsei University is a education organization based out in Seoul, South Korea. It is known for research contribution in the topics: Population & Cancer. The organization has 50162 authors who have published 106172 publications receiving 2279044 citations. The organization is also known as: Yonsei.

Multifunctional Magneto‐Polymeric Nanohybrids for Targeted Detection and Synergistic Therapeutic Effects on Breast Cancer

Abstract: High-resolution molecular and cellular imaging is one of the most promising applications of nanoparticles, and a number of nanostructured materials, especially of cadmium-containing II–VI semiconductors, have been developed to suit this purpose. Recently, it was demonstrated that magnetic nanoparticles can be utilized as excellent magnetic resonance imaging (MRI) probes for noninvasive in vivo monitoring of molecular and cellular events. We recognized the presence of a number of biocompatible polymers suitable for targeted drug delivery and came upon an idea to combine the magnetic nanocrystals as ultrasensitive MR contrast agents, anticancer drugs as chemotherapeutic agents, and biodegradable amphiphilic block copolymers as stabilizers into a multifunctional hybrid nanosystem. The prepared multifunctional magneto-polymeric nanohybrids (MMPNs) further modified by antibodies would seek cancerous parts and allow simultaneous MR imaging and treatment (Scheme 1). Herein, we report a novel protocol for the preparation of MMPNs and characterization to evaluate the sensitivity and stability of prepared nanohybrids. Furthermore, targeted detection ability by MRI and synergistic tumoricidal efficacy on breast cancer cells were investigated for cellular and animal models. Monodispersed magnetic nanocrystals, soluble in organic solvents, were synthesized as reported (Figure 1a,b). To obtain the required water solubility, the hydrophobic nanocrystals and anticancer drug (doxorubicin, DOX) were simultaneously encapsulated with the amphiphilic block copolymer by a nanoemulsion method to give MMPNs. The structures of MMPNs examined by TEM are shown in Figure 1c,d, and the sizes of the MMPNs are consistent with the results from laser scattering: 69.7 8.7 nm (MnFe2O4) and 72.8 9.3 nm (Fe3O4), respectively (see the Supporting Scheme 1. Schematic illustration for the fabrication of MMPNs.

The Y2 Stellar Evolutionary Tracks

Abstract: We present a database of the latest stellar models of the Y2 (Yonsei-Yale) collaboration. This database contains the stellar evolutionary tracks from the pre-main-sequence birthline to the helium core flash that were used to construct the Y2 isochrones. We also provide a simple interpolation routine that generates stellar tracks for given sets of parameters (metallicity, mass, and ?-enhancement).