Yonsei University

About: Yonsei University is a education organization based out in Seoul, South Korea. It is known for research contribution in the topics: Population & Cancer. The organization has 50162 authors who have published 106172 publications receiving 2279044 citations. The organization is also known as: Yonsei.

Short-term Outcomes of a Multicenter Randomized Controlled Trial Comparing Laparoscopic Distal Gastrectomy With D2 Lymphadenectomy to Open Distal Gastrectomy for Locally Advanced Gastric Cancer (KLASS-02-RCT).

Abstract: Objective:The aim of the study was to evaluate the short-term outcomes of KLASS-02-RCT, a multicenter randomized controlled trial comparing laparoscopic distal gastrectomy (LDG) with D2 lymphadenectomy with open distal gastrectomy (ODG).Summary Background Data:Although several benefits of laparoscop

Skyrmion-based artificial synapses for neuromorphic computing

Abstract: Magnetic skyrmions are topologically protected spin textures that have nanoscale dimensions and can be manipulated by an electric current. These properties make the structures potential information carriers in data storage, processing and transmission devices. However, the development of functional all-electrical electronic devices based on skyrmions remains challenging. Here we show that the current-induced creation, motion, detection and deletion of skyrmions at room temperature can be used to mimic the potentiation and depression behaviours of biological synapses. In particular, the accumulation and dissipation of magnetic skyrmions in ferrimagnetic multilayers can be controlled with electrical pulses to represent the variations in the synaptic weights. Using chip-level simulations, we demonstrate that such artificial synapses based on magnetic skyrmions could be used for neuromorphic computing tasks such as pattern recognition. For a handwritten pattern dataset, our system achieves a recognition accuracy of ~89%, which is comparable to the accuracy achieved with software-based ideal training (~93%). The electrical current-induced creation, motion, detection and deletion of skyrmions in ferrimagnetic multilayers can be used to mimic the behaviour of biological synapses, providing devices that could be used for neuromorphic computing tasks such as pattern recognition.

Sterol-dependent regulation of proprotein convertase subtilisin/kexin type 9 expression by sterol-regulatory element binding protein-2.

Abstract: Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a member of the subtilases that promotes the internalization and degradation of LDL receptor in liver and thereby controls the level of LDL cholesterol in plasma. Here, we show that the expression of PCSK9 in HepG2 cells is completely dependent on the absence or presence of sterols. The minimal promoter region of the PCSK9 gene contains a sterol-regulatory element (SRE), which makes the transcription of PCSK9 dependent on sterols. Expression of nuclear forms of sterol-regulatory element binding protein-1 (SREBP-1) and SREBP-2 dramatically increased the promoter activity of PCSK9. In vitro-translated nuclear forms of SREBPs showed interactions with SRE, whereas mutations in SRE abolished their binding. In vivo studies in mice showed that Pcsk9 protein and mRNA were decreased significantly by fasting and increased by refeeding. However, supplementation with 2% cholesterol in the diet prevented the increase in Pcsk9. The amounts of Pcsk9 mRNA in livers of refed mice showed correlated regulation by the changes in the nuclear form of Srebp-2. In summary, it is suggested that the expression of PCSK9 is regulated by sterol at the transcriptional level in HepG2 cells and that both SREBP-1 and SREBP-2 can transcriptionally activate PCSK9 via SRE in its proximal promoter region in vitro. However, in vivo, it is suggested that the sterol-dependent regulation of PCSK9 is mediated predominantly by SREBP-2.

Adaptive Dynamic Surface Control for Stabilization of Parametric Strict-Feedback Nonlinear Systems With Unknown Time Delays

Abstract: The robust stabilization method via the dynamic surface control (DSC) is proposed for uncertain nonlinear systems with unknown time delays in parametric strict-feedback form. That is, the DSC technique is extended to state time delay nonlinear systems with linear parametric uncertainties. The proposed control system can overcome not only the problem of ldquoexplosion of complexityrdquo inherent in the backstepping design method but also the uncertainties of the unknown time delays by choosing appropriate Lyapunov-Krasovskii functionals. In addition, we prove that all the signals in the closed-loop system are semiglobally uniformly bounded. Finally, an example is provided to illustrate the effectiveness of the proposed control system.

Neoangiogenesis and sinusoidal "capillarization" in dysplastic nodules of the liver.

Abstract: The blood supply of hepatocellular carcinoma (HCC) is primarily arterial. Recent studies reported differences of vascular, especially arterial, supply among low- and high-grade dysplastic nodules and HCC. We assessed arterialization using monoclonal antibody specific for smooth muscle actin as well as simultaneous changes in sinusoidal capillarization in cirrhotic nodules, dysplastic nodules, and HCC. We immunohistochemically stained 56 cirrhotic nodules, 20 low-grade dysplastic nodules, 27 high-grade dysplastic nodules, and 20 HCCs for alpha smooth muscle actin (to identify unpaired arteries (i.e., arteries not accompanied by bile ducts) and CD34 (indicating sinusoidal capillarization). Distribution and number of unpaired arteries and distribution of sinusoidal capillarization were graded semiquantitatively. Unpaired arteries were rare in cirrhotic nodules, significantly more common in dysplastic nodules of both types (p < 0.00001), and most common in HCC. Sinusoidal capillarization was least common in cirrhotic nodules, significantly more common in dysplastic nodules (p < 0.0035), and most common in HCC. No topographic relationship between unpaired arteries and sinusoidal capillarization was identified. These findings showed that (1) distributions of sinusoidal capillarization and unpaired arteries in dysplastic nodules are intermediate between those in cirrhotic nodules and HCC, supporting dysplastic nodules as premalignant lesions; (2) unpaired arteries are histologically useful for distinguishing dysplastic nodules from large cirrhotic nodules; and (3) areas of sinusoidal capillarization within dysplastic nodules are unrelated to location of arterialization.