Institution
Yonsei University
Education•Seoul, South Korea•
About: Yonsei University is a education organization based out in Seoul, South Korea. It is known for research contribution in the topics: Population & Cancer. The organization has 50162 authors who have published 106172 publications receiving 2279044 citations. The organization is also known as: Yonsei.
Topics: Population, Cancer, Thin film, Breast cancer, Transplantation
Papers published on a yearly basis
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TL;DR: A new rhodamine-hydroxamic acid-based fluorescent chemosensor for the rapid detection of HOCl in aqueous media was developed and biological imaging studies using living cells and organisms to detect HOCl are successfully demonstrated.
268 citations
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TL;DR: Among patients with established diagnoses at a memory disorder clinic, [18F]flortaucipir PET was able to discriminate AD from other neurodegenerative diseases, and the accuracy and potential utility of this test in patient care require further research in clinically more representative populations.
Abstract: IMPORTANCE The positron emission tomography (PET) tracer [18F]flortaucipir allows in vivo quantification of paired helical filament tau, a core neuropathological feature of Alzheimer disease (AD), but its diagnostic utility is unclear. OBJECTIVE To examine the discriminative accuracy of [18F]flortaucipir for AD vs non-AD neurodegenerative disorders. DESIGN, SETTING, AND PARTICIPANTS In this cross-sectional study, 719 participantswere recruited from 3 dementia centers in South Korea, Sweden, and the United States between June 2014 and November 2017 (160 cognitively normal controls, 126 patients with mild cognitive impairment [MCI], of whom 65.9% were amyloid-β [Aβ] positive [ie, MCI due to AD], 179 patients with AD dementia, and 254 patients with various non-AD neurodegenerative disorders). EXPOSURES The index testwas the [18F]flortaucipir PET standardized uptake value ratio (SUVR) in 5 predefined regions of interest (ROIs). Cut points for tau positivitywere determined using the mean +2 SDs observed in controls and Youden Index for the contrastADdementia vs controls. MAIN OUTCOMES AND MEASURES The reference standardwas the clinical diagnosis determined at the specialized memory centers. In the primary analysis, the discriminative accuracy (ie, sensitivity and specificity) of [18F]flortaucipir was examined for AD dementia vs all non-AD neurodegenerative disorders. In secondary analyses, the area under the curve (AUC) of [18F]flortaucipir SUVR was compared with 3 established magnetic resonance imaging measures (hippocampal volumes and AD signature and whole-brain cortical thickness), and sensitivity and specificity of [18F]flortaucipir in MCI due to AD vs non-AD neurodegenerative disorders were determined. RESULTS Among 719 participants, the overall mean (SD) age was 68.8 (9.2) years and 48.4% were male. The proportions of patients who were amyloid-β positive were 26.3%, 65.9%, 100%, and 23.8% among cognitively normal controls, patients with MCI, patients with AD dementia, and patients with non-AD neurodegenerative disorders, respectively. [18F]flortaucipir uptake in the medial-basal and lateral temporal cortex showed 89.9% (95% CI, 84.6%-93.9%) sensitivity and 90.6%(95%CI, 86.3%-93.9%) specificity using the threshold based on controls (SUVR, 1.34), and 96.8%(95%CI, 92.0%-99.1%) sensitivity and 87.9% (95%CI, 81.9%-92.4%) specificity using the Youden Index-derived cutoff (SUVR, 1.27) for distinguishing AD dementia from all non-AD neurodegenerative disorders. The AUCs for all 5 [18F]flortaucipir ROIs were higher (AUC range, 0.92-0.95) compared with the 3 volumetric MRI measures (AUC range, 0.63-0.75; all ROIs P < .001). Diagnostic performance of the 5 [18F]flortaucipir ROIs were lower in MCI due to AD (AUC range, 0.75-0.84). CONCLUSIONS AND RELEVANCE Among patients with established diagnoses at a memory disorder clinic, [18F]flortaucipir PET was able to discriminate AD from other neurodegenerative diseases. The accuracy and potential utility of this test in patient care require further research in clinically more representative populations.
268 citations
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TL;DR: In vivo testing showed that dermis treated with collagen or collagen-HA matrix was thicker than the control, and epithelial regeneration was accelerated, and collagen synthesis increased, however, no significant effect of HA on wound size reduction was found.
268 citations
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TL;DR: This overview summarizes the status of studies on Prxs and relates the following 10 minireviews.
Abstract: Peroxiredoxins (Prxs) are a very large and highly conserved family of peroxidases that reduce peroxides, with a conserved cysteine residue, designated the "peroxidatic" Cys (CP) serving as the site of oxidation by peroxides (Hall et al., 2011; Rhee et al., 2012). Peroxides oxidize the CP-SH to cysteine sulfenic acid (CP-SOH), which then reacts with another cysteine residue, named the "resolving" Cys (CR) to form a disulfide that is subsequently reduced by an appropriate electron donor to complete a catalytic cycle. This overview summarizes the status of studies on Prxs and relates the following 10 minireviews.
268 citations
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University of Ulsan1, Chungnam National University2, Korea University3, Chonnam National University4, Yonsei University5, Keimyung University6, Catholic University of Korea7, Soonchunhyang University8, Hallym University9, Kangwon National University10, Catholic University of Daegu11, Chonbuk National University12, Kyungpook National University13, Dongguk University14, Inje University15
TL;DR: An additional 24 months of dual antiplatelet therapy versus aspirin alone did not reduce the risk of the composite end point of death from cardiac causes, myocardial infarction, or stroke.
Abstract: Background—The risks and benefits of long-term dual antiplatelet therapy remain unclear Methods and Results—This prospective, multicenter, open-label, randomized comparison trial was conducted in 24 clinical centers in Korea In total, 5045 patients who received drug-eluting stents and were free of major adverse cardiovascular events and major bleeding for at least 12 months after stent placement were enrolled between July 2007 and July 2011 Patients were randomized to receive aspirin alone (n=2514) or clopidogrel plus aspirin (n=2531) The primary end point was a composite of death resulting from cardiac causes, myocardial infarction, or stroke 24 months after randomization At 24 months, the primary end point occurred in 57 aspirin-alone group patients (24%) and 61 dual-therapy group patients (26%; hazard ratio, 094; 95% confidence interval, 066–135; P=075) The 2 groups did not differ significantly in terms of the individual risks of death resulting from any cause, myocardial infarction, stent
267 citations
Authors
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Name | H-index | Papers | Citations |
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Younan Xia | 216 | 943 | 175757 |
Peer Bork | 206 | 697 | 245427 |
Ralph Weissleder | 184 | 1160 | 142508 |
Hyun-Chul Kim | 176 | 4076 | 183227 |
Gregory Y.H. Lip | 169 | 3159 | 171742 |
Yongsun Kim | 156 | 2588 | 145619 |
Jongmin Lee | 150 | 2257 | 134772 |
James M. Tiedje | 150 | 688 | 102287 |
Guanrong Chen | 141 | 1652 | 92218 |
Kazunori Kataoka | 138 | 908 | 70412 |
Herbert Y. Meltzer | 137 | 1148 | 81371 |
Peter M. Rothwell | 134 | 779 | 67382 |
Tae Jeong Kim | 132 | 1420 | 93959 |
Shih-Chang Lee | 128 | 787 | 61350 |
Ming-Hsuan Yang | 127 | 635 | 75091 |