Institution
Yonsei University
Education•Seoul, South Korea•
About: Yonsei University is a education organization based out in Seoul, South Korea. It is known for research contribution in the topics: Population & Cancer. The organization has 50162 authors who have published 106172 publications receiving 2279044 citations. The organization is also known as: Yonsei.
Topics: Population, Cancer, Medicine, Thin film, Breast cancer
Papers published on a yearly basis
Papers
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TL;DR: In this article, the authors proposed a supercapacitor electrode comprising a three-dimensional self-supported hierarchical MnCo-layered double hydroxides [MnCo-LDH@Ni(OH)2] core-shell heterostructure on conductive nickel foam.
Abstract: Rational assembly and hetero-growth of hybrid structures consisting of multiple components with distinctive features are a promising and challenging strategy to develop materials for energy storage applications. Herein, we propose a supercapacitor electrode comprising a three-dimensional self-supported hierarchical MnCo-layered double hydroxides@Ni(OH)2 [MnCo-LDH@Ni(OH)2] core–shell heterostructure on conductive nickel foam. The resultant MnCo-LDH@Ni(OH)2 structure exhibited a high specific capacitance of 2320 F g−1 at a current density of 3 A g−1, and a capacitance of 1308 F g−1 was maintained at a high current density of 30 A g−1 with a superior long cycle lifetime. Moreover, an asymmetric supercapacitor was successfully assembled using MnCo-LDH@Ni(OH)2 as the positive electrode and activated carbon (AC) as the negative electrode. The optimized MnCo-LDH@Ni(OH)2//AC device with a voltage of 1.5 V delivered a maximum energy density of 47.9 W h kg−1 at a power density of 750.7 W kg−1. The energy density remained at 9.8 W h kg−1 at a power density of 5020.5 W kg−1 with excellent cycle stability.
265 citations
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TL;DR: This review focuses on recent studies that highlight the importance of HDAC6‐mediated biological processes, disease mechanisms and HDAC 6‐selective inhibitors.
Abstract: Histone deacetylase (HDAC) 6 is the best-characterized class IIb deacetylase that regulates many important biological processes via the formation of complexes with its partner proteins. HDAC6 is important both for cytoplasmic and nuclear functions. Unlike other deacetylases, HDAC6 has unique substrate specificity for nonhistone proteins. Such diverse functions of HDAC6 suggest that it serves a potential therapeutic target for the treatment of a wide range of diseases. This therapeutic interest in HDAC6 stems from the observation that HDAC6 may be overexpressed or deregulated in various cancers, neurodegenerative diseases and inflammatory disorders. Despite extensive efforts, however, very few HDAC6-selective inhibitors have been identified and the precise structural determinants remain undefined. Future efforts aiming to better define the structure and function of HDAC6 should provide the basis for the discovery of novel effective inhibitors. In this review, we focus on recent studies that highlight the importance of HDAC6-mediated biological processes, disease mechanisms and HDAC6-selective inhibitors.
265 citations
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TL;DR: The hESC-derived DA neurons elicited clear behavioral recovery in three behavioral tests and paves the way for the large-scale generation of purer and functional DA neurons for future clinical applications.
Abstract: We developed a method for the efficient generation of functional dopaminergic (DA) neurons from human embryonic stem cells (hESCs) on a large scale. The most unique feature of this method is the generation of homogeneous spherical neural masses (SNMs) from the hESC-derived neural precursors. These SNMs provide several advantages: (i) they can be passaged for a long time without losing their differentiation capability into DA neurons; (ii) they can be coaxed into DA neurons at much higher efficiency than that from previous reports (86% tyrosine hydroxylase-positive neurons/total neurons); (iii) the induction of DA neurons from SNMs only takes 14 days; and (iv) no feeder cells are required during differentiation. These advantages allowed us to obtain a large number of DA neurons within a short time period and minimized potential contamination of unwanted cells or pathogens coming from the feeder layer. The highly efficient differentiation may not only enhance the efficacy of the cell therapy but also reduce the potential tumor formation from the undifferentiated residual hESCs. In line with this effect, we have never observed any tumor formation from the transplanted animals used in our study. When grafted into a parkinsonian rat model, the hESC-derived DA neurons elicited clear behavioral recovery in three behavioral tests. In summary, our study paves the way for the large-scale generation of purer and functional DA neurons for future clinical applications.
265 citations
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TL;DR: It is shown that pharmacologic or genetic inhibition of either ERK or p38 MAP kinase pathway abolished IL-1β- and TNF-α-induced MUC5AC gene expression in normal human nasal epithelial cells, and the activation of mitogen- and stress-activated protein kinase 1 (MSK1) and cAMP-response element-binding protein and camp- response element signaling cascades are crucial aspects of the intracellular mechanisms that mediate MUC
265 citations
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TL;DR: The results of this study suggest that C. mexicana is one of the most promising candidates for simultaneous nutrient removal and high-efficient biodiesel production.
264 citations
Authors
Showing all 50632 results
Name | H-index | Papers | Citations |
---|---|---|---|
Younan Xia | 216 | 943 | 175757 |
Peer Bork | 206 | 697 | 245427 |
Ralph Weissleder | 184 | 1160 | 142508 |
Hyun-Chul Kim | 176 | 4076 | 183227 |
Gregory Y.H. Lip | 169 | 3159 | 171742 |
Yongsun Kim | 156 | 2588 | 145619 |
Jongmin Lee | 150 | 2257 | 134772 |
James M. Tiedje | 150 | 688 | 102287 |
Guanrong Chen | 141 | 1652 | 92218 |
Kazunori Kataoka | 138 | 908 | 70412 |
Herbert Y. Meltzer | 137 | 1148 | 81371 |
Peter M. Rothwell | 134 | 779 | 67382 |
Tae Jeong Kim | 132 | 1420 | 93959 |
Shih-Chang Lee | 128 | 787 | 61350 |
Ming-Hsuan Yang | 127 | 635 | 75091 |