Yonsei University

About: Yonsei University is a education organization based out in Seoul, South Korea. It is known for research contribution in the topics: Population & Cancer. The organization has 50162 authors who have published 106172 publications receiving 2279044 citations. The organization is also known as: Yonsei.

Development of an Effective Double-Moment Cloud Microphysics Scheme with Prognostic Cloud Condensation Nuclei (CCN) for Weather and Climate Models

Abstract: A new double-moment bulk cloud microphysics scheme, the Weather Research and Forecasting (WRF) Double-Moment 6-class (WDM6) Microphysics scheme, which is based on the WRF Single-Moment 6-class (WSM6) Microphysics scheme, has been developed. In addition to the prediction for the mixing ratios of six water species (water vapor, cloud droplets, cloud ice, snow, rain, and graupel) in the WSM6 scheme, the number concentrations for cloud and rainwater are also predicted in the WDM6 scheme, together with a prognostic variable of cloud condensation nuclei (CCN) number concentration. The new scheme was evaluated on an idealized 2D thunderstorm test bed. Compared to the simulations from the WSM6 scheme, there are greater differences in the droplet concentration between the convective core and stratiform region in WDM6. The reduction of light precipitation and the increase of moderate precipitation accompanying a marked radar bright band near the freezing level from the WDM6 simulation tend to alleviate existing systematic biases in the case of the WSM6 scheme. The strength of this new microphysics scheme is its ability toallowflexibilityinvariableraindropsizedistributionbypredictingthenumberconcentrationsofcloudsand rain, coupled with the explicit CCN distribution, at a reasonable computational cost.

A long-term follow-up study of intravenous autologous mesenchymal stem cell transplantation in patients with ischemic stroke.

Abstract: We previously evaluated the short-term follow-up preliminary data of mesenchymal stem cells (MSCs) transplantation in patients with ischemic stroke. The present study was conducted to evaluate the long-term safety and efficacy of i.v. MSCs transplantation in a larger population. To accomplish this, we performed an open-label, observer-blinded clinical trial of 85 patients with severe middle cerebral artery territory infarct. Patients were randomly allocated to one of two groups, those who received i.v. autologous ex vivo cultured MSCs (MSC group) or those who did not (control group), and followed for up to 5 years. Mortality of any cause, long-term side effects, and new-onset comorbidities were monitored. Of the 52 patients who were finally included in this study, 16 were the MSC group and 36 were the control group. Four (25%) patients in the MSC group and 21 (58.3%) in the control group died during the follow-up period, and the cumulative surviving portion at 260 weeks was 0.72 in the MSC group and 0.34 in the control group (log-rank; p = .058). Significant side effects were not observed following MSC treatment. The occurrence of comorbidities including seizures and recurrent vascular episodes did not differ between groups. When compared with the control group, the follow-up modified Rankin Scale (mRS) score was decreased, whereas the number of patients with a mRS of 0-3 increased in the MSC group (p = .046). Clinical improvement in the MSC group was associated with serum levels of stromal cell-derived factor-1 and the degree of involvement of the subventricular region of the lateral ventricle. Intravenous autologous MSCs transplantation was safe for stroke patients during long-term follow-up. This therapy may improve recovery after stroke depending on the specific characteristics of the patients.

Control of colloidal particle deposit patterns within picoliter droplets ejected by ink-jet printing.

Abstract: Particle deposit morphologies that resulted from evaporating ink-jetted microdroplets were controlled by varying the ink compositions and concentrations. The ink was a well-dispersed aqueous dispersion of monodisperse silica microspheres. Silica particles suspended in the microdroplet undergo self-assembly upon the evaporation of the solvent. A ringlike deposit of the self-assembled silica particles was produced from the water-based ink, while a uniform two-dimensional monolayer with a well-ordered hexagonal structure was obtained from the mixed-solvent-based inks. Variations in the deposit patterns can be explained in terms of competing effects between the convective and Marangoni flows, which vary with the types of the high-boiling-point solvent added to the ink. The macroscopic shape and microstructure of the silica colloidal deposits were observed by SEM, AFM, and a confocal microscope.

Improvement of the K-profile Model for the Planetary Boundary Layer based on Large Eddy Simulation Data

Abstract: Modifications of the widely used K-profile model of the planetary boundary layer (PBL), reported by Troen and Mahrt (TM) in 1986, are proposed and their effects examined by comparison with large eddy simulation (LES) data. The modifications involve three parts. First, the heat flux from the entrainment at the inversion layer is incorporated into the heat and momentum profiles, and it is used to predict the growth of the PBL directly. Second, profiles of the velocity scale and the Prandtl number in the PBL are proposed, in contrast to the constant values used in the TM model. Finally, non-local mixing of momentum was included. The results from the new PBL model and the original TM model are compared with LES data. The TM model was found to give too high PBL heights in the PBL with strong shear, and too low heights for the convection-dominated PBL, which causes unrealistic heat flux profiles. The new PBL model improves the predictability of the PBL height and produces profiles that are more realistic. Moreover, the new PBL model produces more realistic profiles of potential temperature and velocity. We also investigated how each of these three modifications affects the results, and found that explicit representation of the entrainment rate is the most critical.