Yonsei University

About: Yonsei University is a education organization based out in Seoul, South Korea. It is known for research contribution in the topics: Population & Cancer. The organization has 50162 authors who have published 106172 publications receiving 2279044 citations. The organization is also known as: Yonsei.

Anisotropic Shape Control of Colloidal Inorganic Nanocrystals

Abstract: The systematic shape control of colloidal nanocrystals including one-dimensional (1D) nanorods remains a key issue in the “bottom–up” approach of nanoscience. Here, we examine the anisotropic structural evolution of various semiconductor nanocrystals and systematically elucidate the key growth parameters for their shape control. The crystalline phase of nucleating seeds and kinetic growth regimes controlled by changing growth parameters are crucial for the determination of the 1D nanocrystal geometry.

Exome sequencing of gastric adenocarcinoma identifies recurrent somatic mutations in cell adhesion and chromatin remodeling genes

Abstract: Gastric cancer is a major cause of global cancer mortality. We surveyed the spectrum of somatic alterations in gastric cancer by sequencing the exomes of 15 gastric adenocarcinomas and their matched normal DNAs. Frequently mutated genes in the adenocarcinomas included TP53 (11/15 tumors), PIK3CA (3/15) and ARID1A (3/15). Cell adhesion was the most enriched biological pathway among the frequently mutated genes. A prevalence screening confirmed mutations in FAT4, a cadherin family gene, in 5% of gastric cancers (6/110) and FAT4 genomic deletions in 4% (3/83) of gastric tumors. Frequent mutations in chromatin remodeling genes (ARID1A, MLL3 and MLL) also occurred in 47% of the gastric cancers. We detected ARID1A mutations in 8% of tumors (9/110), which were associated with concurrent PIK3CA mutations and microsatellite instability. In functional assays, we observed both FAT4 and ARID1A to exert tumor-suppressor activity. Somatic inactivation of FAT4 and ARID1A may thus be key tumorigenic events in a subset of gastric cancers.

A comprehensive survey of genomic alterations in gastric cancer reveals systematic patterns of molecular exclusivity and co-occurrence among distinct therapeutic targets

Abstract: Objective Gastric cancer is a major gastrointestinal malignancy for which targeted therapies are emerging as treatment options. This study sought to identify the most prevalent molecular targets in gastric cancer and to elucidate systematic patterns of exclusivity and co-occurrence among these targets, through comprehensive genomic analysis of a large panel of gastric cancers. Design Using high-resolution single nucleotide polymorphism arrays, copy number alterations were profiled in a panel of 233 gastric cancers (193 primary tumours, 40 cell lines) and 98 primary matched gastric non-malignant samples. For selected alterations, their impact on gene expression and clinical outcome were evaluated. Results 22 recurrent focal alterations (13 amplifications and nine deletions) were identified. These included both known targets ( FGFR2 , ERBB2 ) and also novel genes in gastric cancer ( KLF5 , GATA6 ). Receptor tyrosine kinase (RTK)/RAS alterations were found to be frequent in gastric cancer. This study also demonstrates, for the first time, that these alterations occur in a mutually exclusive fashion, with KRAS gene amplifications highlighting a clinically relevant but previously underappreciated gastric cancer subgroup. FGFR2 -amplified gastric cancers were also shown to be sensitive to dovitinib, an orally bioavailable FGFR/VEGFR targeting agent, potentially representing a subtype-specific therapy for FGFR2 -amplified gastric cancers. Conclusion The study demonstrates the existence of five distinct gastric cancer patient subgroups, defined by the signature genomic alterations FGFR2 (9% of tumours), KRAS (9%), EGFR (8%), ERBB2 (7%) and MET (4%). Collectively, these subgroups suggest that at least 37% of gastric cancer patients may be potentially treatable by RTK/RAS directed therapies.

Elliptic flow of identified hadrons in [formula presented] collisions at [formula presented]

Abstract: The anisotropy parameter (v(2)), the second harmonic of the azimuthal particle distribution, has been measured with the PHENIX detector in Au+Au collisions at roots(NN)=200 GeV for identified and inclusive charged particle production at central rapidities (eta 2 GeV/c, in marked contrast to the predictions of a hydrodynamical model. A quark-coalescence model is also investigated.

A Survey of In-Band Full-Duplex Transmission: From the Perspective of PHY and MAC Layers

Abstract: In-band full-duplex (IBFD) transmission represents an attractive option for increasing the throughput of wireless communication systems A key challenge for IBFD transmission is reducing self-interference Fortunately, the power associated with residual self-interference can be effectively canceled for feasible IBFD transmission with combinations of various advanced passive, analog, and digital self-interference cancellation schemes In this survey paper, we first review the basic concepts of IBFD transmission with shared and separated antennas and advanced self-interference cancellation schemes Furthermore, we also discuss the effects of IBFD transmission on system performance in various networks such as bidirectional, relay, and cellular topology networks This survey covers a wide array of technologies that have been proposed in the literature as feasible for IBFD transmission and evaluates the performance of the IBFD systems compared to conventional half-duplex transmission in connection with theoretical aspects such as the achievable sum rate, network capacity, system reliability, and so on We also discuss the research challenges and opportunities associated with the design and analysis of IBFD systems in a variety of network topologies This work also explores the development of MAC protocols for an IBFD system in both infrastructure-based and ad hoc networks Finally, we conclude our survey by reviewing the advantages of IBFD transmission when applied for different purposes, such as spectrum sensing, network secrecy, and wireless power transfer