Institution
Yonsei University
Education•Seoul, South Korea•
About: Yonsei University is a education organization based out in Seoul, South Korea. It is known for research contribution in the topics: Population & Cancer. The organization has 50162 authors who have published 106172 publications receiving 2279044 citations. The organization is also known as: Yonsei.
Topics: Population, Cancer, Medicine, Thin film, Breast cancer
Papers published on a yearly basis
Papers
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TL;DR: The identification of a specific subcellular structure in which, under basal conditions, the 20S proteasome, the PA700 and PA28 (700- and 180-kD proteasomal activator complexes, respectively), ubiquitin, Hsp70 and Hsp90 (70- and 90- kD heat shock protein, respectively) concentrate in HEK 293 and HeLa cells is reported.
Abstract: Although the number of pathologies known to arise from the inappropriate folding of proteins continues to grow, mechanisms underlying the recognition and ultimate disposition of misfolded polypeptides remain obscure. For example, how and where such substrates are identified and processed is unknown. We report here the identification of a specific subcellular structure in which, under basal conditions, the 20S proteasome, the PA700 and PA28 (700- and 180-kD proteasome activator complexes, respectively), ubiquitin, Hsp70 and Hsp90 (70- and 90-kD heat shock protein, respectively) concentrate in HEK 293 and HeLa cells. The structure is perinuclear, surrounded by endoplasmic reticulum, adjacent to the Golgi, and colocalizes with gamma-tubulin, an established centrosomal marker. Density gradient fractions containing purified centrosomes are enriched in proteasomal components and cell stress chaperones. The centrosome-associated structure enlarges in response to inhibition of proteasome activity and the level of misfolded proteins. For example, folding mutants of CFTR form large inclusions which arise from the centrosome upon inhibition of proteasome activity. At high levels of misfolded protein, the structure not only expands but also extensively recruits the cytosolic pools of ubiquitin, Hsp70, PA700, PA28, and the 20S proteasome. Thus, the centrosome may act as a scaffold, which concentrates and recruits the systems which act as censors and modulators of the balance between folding, aggregation, and degradation.
514 citations
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Johns Hopkins University1, University of Iowa2, University of Pittsburgh3, Utah State University4, Peking University5, Johns Hopkins University School of Medicine6, National Institutes of Health7, University of Bergen8, Icahn School of Medicine at Mount Sinai9, Chang Gung University10, Wuhan University11, Peking Union Medical College12, Boston Children's Hospital13, National University of Singapore14, Yonsei University15, Sichuan University16, University of Southern Denmark17, Statens Serum Institut18, Oswaldo Cruz Foundation19, University of British Columbia20, Trinity College, Dublin21, University of Miami22
TL;DR: In this paper, case-parent trios were used in a genome-wide association study of cleft lip with and without cleft palate, and two previously identified regions (at chromosome 8q24 and IRF6) attained genomewide significance.
Abstract: Case-parent trios were used in a genome-wide association study of cleft lip with and without cleft palate. SNPs near two genes not previously associated with cleft lip with and without cleft palate (MAFB, most significant SNP rs13041247, with odds ratio (OR) per minor allele = 0.704, 95% CI 0.635-0.778, P = 1.44 x 10(-11); and ABCA4, most significant SNP rs560426, with OR = 1.432, 95% CI 1.292-1.587, P = 5.01 x 10(-12)) and two previously identified regions (at chromosome 8q24 and IRF6) attained genome-wide significance. Stratifying trios into European and Asian ancestry groups revealed differences in statistical significance, although estimated effect sizes remained similar. Replication studies from several populations showed confirming evidence, with families of European ancestry giving stronger evidence for markers in 8q24, whereas Asian families showed stronger evidence for association with MAFB and ABCA4. Expression studies support a role for MAFB in palatal development.
512 citations
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University of Kentucky1, Yonsei University2, University of Florida3, University of Colorado Boulder4, Meharry Medical College5, MRC Mitochondrial Biology Unit6, University of Pennsylvania7, University of Utah8, Veterans Health Administration9, Nagoya City University10, Sungkyunkwan University11, Laval University12, University of Southern California13, University of Michigan14
TL;DR: It is shown that DICER1 deficit or Alu RNA exposure activates the NLRP3 inflammasome and triggers TLR-independent MyD88 signaling via IL18 in the RPE and reveals a function of the inflammaome outside the immune system and an immunomodulatory action of mobile elements.
511 citations
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TL;DR: The concept of group social capital as mentioned in this paper was introduced to describe the set of resources made available to a group through members' social relationships within the social structure of the group and in the broader formal and informal structures of the organization.
Abstract: We introduce the concept of group social capital—the set of resources made available to a group through members' social relationships within the social structure of the group and in the broader formal and informal structure of the organization. We argue that greater group social capital resources lead to greater group effectiveness and that there are many different conduits through which group social capital resources flow. We present a multilevel, multidimensional model arguing that an optimal balance of all these conduits maximizes group social capital resources and group effectiveness.
511 citations
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TL;DR: In this paper, the authors showed that the formation of filamentous carbon was significantly influenced by the metal particle size and proceeded mostly over the metal particles larger than 7-nm, and the loss of catalytic activity at 973 K was mainly caused by coke deposition and sintering.
Abstract: CO2 reforming of CH4 was carried out over Ni–alumina aerogel catalysts prepared with various Ni loadings. The preparation of alumina supported Ni catalysts via sol–gel synthesis and subsequent supercritical drying led to the formation of very small metal particles, which are evenly distributed over the alumina support. The activity of the aerogel catalysts increased along with increasing metal loading, and eventually, the SAA25 (0.25 in Ni/Al mole ratio) catalyst exhibited the high activity comparable to that of a 5 wt.% Ru/alumina catalyst (ESCAT44, Engelhard). Compared to the alumina-supported Ni catalyst prepared by conventional impregnation method, Ni–alumina aerogel catalysts showed a remarkably low coking rate due to highly dispersed metal particles. From TEM micrograph studies, it was observed that the formation of filamentous carbon was significantly influenced by the metal particle size and proceeded mostly over the metal particles larger than 7 nm. The loss of catalytic activity at 973 K was mainly caused by coke deposition and sintering.
510 citations
Authors
Showing all 50632 results
Name | H-index | Papers | Citations |
---|---|---|---|
Younan Xia | 216 | 943 | 175757 |
Peer Bork | 206 | 697 | 245427 |
Ralph Weissleder | 184 | 1160 | 142508 |
Hyun-Chul Kim | 176 | 4076 | 183227 |
Gregory Y.H. Lip | 169 | 3159 | 171742 |
Yongsun Kim | 156 | 2588 | 145619 |
Jongmin Lee | 150 | 2257 | 134772 |
James M. Tiedje | 150 | 688 | 102287 |
Guanrong Chen | 141 | 1652 | 92218 |
Kazunori Kataoka | 138 | 908 | 70412 |
Herbert Y. Meltzer | 137 | 1148 | 81371 |
Peter M. Rothwell | 134 | 779 | 67382 |
Tae Jeong Kim | 132 | 1420 | 93959 |
Shih-Chang Lee | 128 | 787 | 61350 |
Ming-Hsuan Yang | 127 | 635 | 75091 |