Yonsei University

About: Yonsei University is a education organization based out in Seoul, South Korea. It is known for research contribution in the topics: Population & Cancer. The organization has 50162 authors who have published 106172 publications receiving 2279044 citations. The organization is also known as: Yonsei.

Energy loss and flow of heavy quarks in Au+Au collisions at sNN=200GeV

Abstract: The PHENIX experiment at the BNL Relativistic Heavy Ion Collider (RHIC) has measured electrons with 0.3 < p(T) < 9 GeV/c at midrapidity (y < 0.35) from heavy-flavor (charm and bottom) decays in Au + Au collisions at root s(NN) = 200 GeV. The nuclear modification factor R-AA relative to p + p collisions shows a strong suppression in central Au + Au collisions, indicating substantial energy loss of heavy quarks in the medium produced at RHIC energies. A large azimuthal anisotropy v(2) with respect to the reaction plane is observed for 0.5 < p(T) < 5 GeV/c indicating substantial heavy-flavor elliptic flow. Both R-AA and v(2) show a p(T) dependence different from those of neutral pions. A comparison to transport models which simultaneously describe R-AA(p(T)) and v(2)(p(T)) suggests that the viscosity to entropy density ratio is close to the conjectured quantum lower bound, i.e., near a perfect fluid.

Cohort profile: The National Health Insurance Service-National Health Screening Cohort (NHIS-HEALS) in Korea

Abstract: Purpose The National Health Insurance Service-Health Screening Cohort (NHIS-HEALS) is a cohort of participants who participated in health screening programmes provided by the NHIS in the Republic of Korea The NHIS constructed the NHIS-HEALS cohort database in 2015 The purpose of this cohort is to offer relevant and useful data for health researchers, especially in the field of non-communicable diseases and health risk factors, and policy-maker Participants To construct the NHIS-HEALS database, a sample cohort was first selected from the 2002 and 2003 health screening participants, who were aged between 40 and 79 in 2002 and followed up through 2013 This cohort included 514 866 health screening participants who comprised a random selection of 10% of all health screening participants in 2002 and 2003 Findings to date The age-standardised prevalence of anaemia, diabetes mellitus, hypertension, obesity, hypercholesterolaemia and abnormal urine protein were 98%, 82%, 356%, 27%, 142% and 20%, respectively The age-standardised mortality rate for the first 2 years (through 2004) was 4420 per 100 000 person-years, while the rate for 10 years (through 2012) was 8659 per 100 000 person-years The most common cause of death was malignant neoplasm in both sexes (3641 per 100 000 person-years for men, 1283 per 100 000 person-years for women) Future plans This database can be used to study the risk factors of non-communicable diseases and dental health problems, which are important health issues that have not yet been fully investigated The cohort will be maintained and continuously updated by the NHIS

Discovery of Q203, a potent clinical candidate for the treatment of tuberculosis

Abstract: New therapeutic strategies are needed to combat the tuberculosis pandemic and the spread of multidrug-resistant (MDR) and extensively drug-resistant (XDR) forms of the disease, which remain a serious public health challenge worldwide. The most urgent clinical need is to discover potent agents capable of reducing the duration of MDR and XDR tuberculosis therapy with a success rate comparable to that of current therapies for drug-susceptible tuberculosis. The last decade has seen the discovery of new agent classes for the management of tuberculosis, several of which are currently in clinical trials. However, given the high attrition rate of drug candidates during clinical development and the emergence of drug resistance, the discovery of additional clinical candidates is clearly needed. Here, we report on a promising class of imidazopyridine amide (IPA) compounds that block Mycobacterium tuberculosis growth by targeting the respiratory cytochrome bc1 complex. The optimized IPA compound Q203 inhibited the growth of MDR and XDR M. tuberculosis clinical isolates in culture broth medium in the low nanomolar range and was efficacious in a mouse model of tuberculosis at a dose less than 1 mg per kg body weight, which highlights the potency of this compound. In addition, Q203 displays pharmacokinetic and safety profiles compatible with once-daily dosing. Together, our data indicate that Q203 is a promising new clinical candidate for the treatment of tuberculosis.

Ag Nanowire Reinforced Highly Stretchable Conductive Fibers for Wearable Electronics

Abstract: Stretchable conductive fi bers have received signifi cant attention due to their possibility of being utilized in wearable and foldable electronics. Here, highly stretchable conductive fi ber composed of silver nanowires (AgNWs) and silver nanoparticles (AgNPs) embedded in a styrene‐butadiene‐styrene (SBS) elastomeric matrix is fabricated. An AgNW-embedded SBS fi ber is fabricated by a simple wet spinning method. Then, the AgNPs are formed on both the surface and inner region of the AgNW-embedded fi ber via repeated cycles of silver precursor absorption and reduction processes. The AgNW-embedded conductive fi ber exhibits superior initial electrical conductivity ( σ 0 = 2450 S cm −1 ) and elongation at break (900% strain) due to the high weight percentage of the conductive fi llers and the use of a highly stretchable SBS elastomer matrix. During the stretching, the embedded AgNWs act as conducting bridges between AgNPs, resulting in the preservation of electrical conductivity under high strain (the rate of conductivity degradation, σ / σ 0 = 4.4% at 100% strain). The AgNW-embedded conductive fi bers show the strain-sensing behavior with a broad range of applied tensile strain. The AgNW reinforced highly stretchable conductive fi bers can be embedded into a smart glove for detecting sign language by integrating fi ve composite fi bers in the glove, which can successfully perceive human motions.

A cost/benefit approach to understanding service loyalty

Abstract: Examines determinants of service loyalty under the assumption that consumers perform a cost/benefit analysis when deciding whether or not they want to be “regular customers”. It develops potential determinants of service loyalty based on the service quality, transaction cost, and switching cost literature, and estimates their relative influences with survey data from customers currently using banks and travel agencies. The results indicate that, in addition to service quality perceptions, transaction/switching cost factors have a significant impact on service loyalty. Implications of the results are discussed.