Yonsei University

About: Yonsei University is a education organization based out in Seoul, South Korea. It is known for research contribution in the topics: Population & Cancer. The organization has 50162 authors who have published 106172 publications receiving 2279044 citations. The organization is also known as: Yonsei.

On the origin of leprosy

Abstract: Leprosy, a chronic human disease with potentially debilitating neurological consequences, results from infection with Mycobacterium leprae. This unculturable pathogen has undergone extensive reductive evolution, with half of its genome now occupied by pseudogenes. Using comparative genomics, we demonstrated that all extant cases of leprosy are attributable to a single clone whose dissemination worldwide can be retraced from analysis of very rare single-nucleotide polymorphisms. The disease seems to have originated in Eastern Africa or the Near East and spread with successive human migrations. Europeans or North Africans introduced leprosy into West Africa and the Americas within the past 500 years.

The effects of virtual reality on consumer learning: an empirical investigation

Abstract: As competition in business-to-consumer e-commerce becomes fiercer, Web-based stores are attempting to attract consumers' attention by exploiting state-of-the-art technologies. Virtual reality (VR) on the Internet has been gaining prominence recently because it enables consumers to experience products realistically over the Internet, there by mitigating the problems associated with consumers' lack of physical contact with products. However, while the employment of VR has increased in B2C e-commerce, its impact has not been explored extensively by research in the IS field. This study investigates whether and under what circumstances VR enhances consumer learning about products. In general, VR enables consumers to learn about products thoroughly by providing high-quality three-dimensional images of products, interactivity with the products, and increased telepresence. In addition, congruent with the theory of cognitive fit, the effects of VR are more pronounced when it exhibits products whose salient attributes are completely apparent through visual and auditory cues (because most VR on desktop computers uses only those two sensory modalities to deliver information). Based on these attributes, we distinguish between two types of products-namely, virtually high experiential (VHE) and virtually low experiential (VLE) products-in terms of the sensory modalities that are used and required for product inspection. Hypotheses arising from the distinctions expressed by these terms were tested via a laboratory experiment. The results support the predictions that VR interfaces increase overall consumer learning about products and that these effects extend to VHE products more significantly than to VLE products.

한국인 직무 스트레스 측정도구의 개발 및 표준화

Abstract: 목적: 이 연구의 목적은 우리나라 직장인들의 직무스트레스를 측정하기 위한 신뢰성과 타당성 있는 도구를 개발하고 평가기준 및 참고치를 제시하기 위해 수행되었다. 대상 및 방법: 연구 대상은 2차의 걸친 표본추출과정에 의해 선정되었다. 1차 표본은 NSDSOS 프로젝트의 수행을 위해 고안된 3개의 광역권에서 조사된 직장인 30, 146명이고, 2차 표본은 우리나라 표준산업분류(대분류 및 중분류)에 따른 근로자 인구 분포를 고려하여 확률 추출되어 선정된 12, 631명으로 이들을 대상으로 하여 표준화 작업과 규준을 마련하였다. 전문가 회의와 사전조사를 통해 작성된 구조화된 설문지를 이용하여 일반적 특성, 직업적 특성, 건강상태(가족력, 질병 과거력 및 의료이용현황), 직무스트레스 측정도구, 단축형 사회심리적 스트레스(PWI-SF), 피로(MFS) 등을 측정하였다. 그리고 한국인 직무스트레스 수준을 측정 평가할 수 있는 표준화된 측정도구와 평가를 위한 성별 평가기준 및 참고치를 도출하였다. 결과: 한국인의 직무스트레스 요인으로 간주될 수 있는 요인을 기존 연구와 외국의 연구결과를 검토 분석하여 총8개의 하위 영역을 도출하였다. 이들 하위 영역에 포함된 항목들은 물리환경, 직무 요구, 직무 자율성 결여, 관계 갈등, 직무 불안정, 조직체계, 보상 부적절, 직장문화 등이었다. 이들 하위 영역을 대표할 수 있는 측정 문항을 개발하여 현장조사를 하였으며, 조사결과를 바탕으로 한국인 직무스트레스 수준을 측정할 수 있는 총 43개 문항의 표준화된 측정도구를 개발하였다. 아울러 산업 현장에서 간편하게 사용할 수 있는 24개 문항으로 구성된 단축형 설문지도 개발하였다. 직무 스트레스수준에 대한 측정결과를 평가하기 위해 남자와 여자를 구분하고 기본형 설문지와 단축형 설문지를 바탕으로 평가의 참고치를 도출하였다. 결론: 한국인 직장인들의 직무 스트레스를 측정을 위해 개발된 KOSS는 한국 특이적인 일반적인 직무 스트레스요인을 질적 방법과 기존의 표준화된 측정도구들의 검토, 그리고 연구에 참여한 공동 연구원들이 제시한 직무 스트레스 항목들이 총체적으로 반영된 도구로서 타당성 평가에서도 만족할만한 수준을 보여 객관적이고 타당성있는 직무 스트레스 측정도구로서 직장인 직무스트레스 관리를 위한 기초 정보산출 및 평가에 기여할 수 있을 것으로 본다.

Everolimus for previously treated advanced gastric cancer: Results of the randomized, double-blind, phase III GRANITE-1 study

Abstract: Purpose The oral mammalian target of rapamycin inhibitor everolimus demonstrated promising efficacy in a phase II study of pretreated advanced gastric cancer. This international, double-blind, phase III study compared everolimus efficacy and safety with that of best supportive care (BSC) in previously treated advanced gastric cancer. Patients and Methods Patients with advanced gastric cancer that progressed after one or two lines of systemic chemotherapy were randomly assigned to everolimus 10 mg/d (assignment schedule: 2:1) or matching placebo, both given with BSC. Randomization was stratified by previous chemotherapy lines (one v two) and region (Asia v rest of the world [ROW]). Treatment continued until disease progression or intolerable toxicity. Primary end point was overall survival (OS). Secondary end points included progression-free survival (PFS), overall response rate, and safety. Results Six hundred fifty-six patients (median age, 62.0 years; 73.6% male) were enrolled. Median OS was 5.4 months ...