Showing papers by "York University published in 2003"

Pharmaceutical industry sponsorship and research outcome and quality: systematic review

Abstract: Objective To investigate whether funding of drug studies by the pharmaceutical industry is associated with outcomes that are favourable to the funder and whether the methods of trials funded by pharmaceutical companies differ from the methods in trials with other sources of support Methods Medline (January 1966 to December 2002) and Embase (January 1980 to December 2002) searches were supplemented with material identified in the references and in the authors' personal files Data were independently abstracted by three of the authors and disagreements were resolved by consensus Results 30 studies were included Research funded by drug companies was less likely to be published than research funded by other sources Studies sponsored by pharmaceutical companies were more likely to have outcomes favouring the sponsor than were studies with other sponsors (odds ratio 405; 95% confidence interval 298 to 551; 18 comparisons) None of the 13 studies that analysed methods reported that studies funded by industry was of poorer quality Conclusion Systematic bias favours products which are made by the company funding the research Explanations include the selection of an inappropriate comparator to the product being investigated and publication bias

Teaching Old Brands New Tricks: Retro Branding and the Revival of Brand Meaning

Abstract: Retro brands are relaunched historical brands with updated features. The authors conduct a "netnographic" analysis of two prominent retro brands, the Volkswagen New Beetle and Star Wars: Episode I — The Phantom Menace, that reveals the importance of Allegory (brand story), Aura (brand essence), Arcadia (idealized community), and Antinomy (brand paradox). Retro brand meanings are predicated on a Utopian communal element and an enlivening paradoxical essence. Retro brand management involves an uneasy, cocreative, and occasionally clamorous alliance between producers and consumers.

Skyline with presorting

Abstract: The skyline, or Pareto, operator selects those tuples that are not dominated by any others. Extending relational systems with the skyline operator would offer a basis for handling preference queries. Good algorithms are needed for skyline, however, to make this efficient in a relational setting. We propose a skyline algorithm, SFS, based on presorting that is general, for use with any skyline query, efficient, and well behaved in a relational setting.

Organizational Slack and Firm Performance During Economic Transitions: Two Studies from an Emerging Economy

Abstract: How does organizational slack affect firm performance? Organization theory posits that slack, despite its costs, has a positive impact on firm performance. In contrast, agency theory suggests that slack breeds inefficiency and inhibits performance. The empirical evidence, largely from developed economies, has been inconclusive. Moreover, little effort has been made to empirically test whether such an impact (positive or negative) is linear or curvilinear. This article joins the debate by extending empirical work to the largely unexplored context of economic transitions. Specifically, two studies, based on survey and archival data (N = 57 and 1532 firms, respectively), are undertaken in China’s emerging economy. Our results suggest (1) that organization theory generates stronger predictions when dealing with unabsorbed slack, and (2) that agency theory yields stronger validity when focusing on absorbed slack. Furthermore, we also find that the impact of slack on performance is curvilinear, which resembles inverse U-shaped curves. Overall, our findings call for a contingency perspective to specify the nature of slack when discussing its impact on firm performance.

Phrase sets for evaluating text entry techniques

Abstract: In evaluations of text entry methods, participants enter phrases of text using a technique of interest while performance data are collected. This paper describes and publishes (via the internet) a collection of 500 phrases for such evaluations. Utility programs are also provided to compute statistical properties of the phrase set, or any other phrase set. The merits of using a pre-defined phrase set are described as are methodological considerations, such as attaining results that are generalizable and the possible addition of punctuation and other characters.

Winter Blues: A SAD Stock Market Cycle

Abstract: This paper investigates the role of seasonal affective disorder (SAD) in the seasonal time-variation of stock market returns. SAD is an extensively documented medical condition whereby the shortness of the days in fall and winter leads to depression for many people. Experimental research in psychology and economics indicates that depression, in turn, causes heightened risk aversion. Building on these links between the length of day, depression, and risk aversion, we provide international evidence that stock market returns vary seasonally with the length of the day, a result we call the SAD effect. Using data from numerous stock exchanges and controlling for well-known market seasonals as well as other environmental factors, stock returns are shown to be significantly related to the amount of daylight through the fall and winter. Patterns at different latitudes and in both hemispheres provide compelling evidence of a link between seasonal depression and seasonal variation in stock returns: Higher latitude markets show more pronounced SAD effects and results in the Southern Hemisphere are six months out of phase, as are the seasons. Overall, the economic magnitude of the SAD effect is large.

Lower level mediation in multilevel models.

Abstract: Multilevel models are increasingly used to estimate models for hierarchical and repeated measures data. The authors discuss a model in which there is mediation at the lower level and the mediational links vary randomly across upper level units. One repeated measures example is a case in which a person's daily stressors affect his or her coping efforts, which affect his or her mood, and both links vary randomly across persons. Where there is mediation at the lower level and the mediational links vary randomly across upper level units, the formulas for the indirect effect and its standard error must be modified to include the covariance between the random effects. Because no standard method can estimate such a model, the authors developed an ad hoc method that is illustrated with real and simulated data. Limitations of this method and characteristics of an ideal method are discussed.

Rigour and grounded theory research

Abstract: Background Grounded theory methodology is a suitable qualitative research approach for clinical inquiry into nursing practice, leading to theory development in nursing. Given the variations in, and subjectivity attached to, the manner in which qualitative research is carried out, it is important for researchers to explain the process of how a theory about a nursing phenomenon was generated. Similarly, when grounded theory research reports are reviewed for clinical use, nurses need to look for researchers' explanations of their inquiry process. Aim The focus of this article is to discuss the practical application of grounded theory procedures as they relate to rigour. Method Reflecting on examples from a grounded theory research study, we suggest eight methods of research practice to delineate further Beck's schema for ensuring, credibility, auditability and fittingness, which are all components of rigour. Findings The eight methods of research practice used to enhance rigour in the course of conducting a grounded theory research study were: (1) let participants guide the inquiry process; (2) check the theoretical construction generated against participants' meanings of the phenomenon; (3) use participants' actual words in the theory; (4) articulate the researcher's personal views and insights about the phenomenon explored; (5) specify the criteria built into the researcher's thinking; (6) specify how and why participants in the study were selected; (7) delineate the scope of the research; and (8) describe how the literature relates to each category which emerged in the theory. Conclusions The eight methods of research practice should be of use to those in nursing research, management, practice and education in enhancing rigour during the research process and for critiquing published grounded theory research reports.

The Balloon Analogue Risk Task (BART) differentiates smokers and nonsmokers.

Abstract: In trying to better understand why individuals begin and continue to smoke despite the obvious health consequences, researchers have become interested in identifying relevant personality variables, such as risk taking. In this study, the authors compared the ability of 2 behavioral measures of risk taking, the Bechara Gambling Task (BGT) and the Balloon Analogue Risk Task (BART), to differentiate smokers and nonsmokers. Self-report measures of impulsivity and sensation seeking were taken for comparison with the 2 behavioral risk-taking tasks. Results indicate that behavior on the BART, and not the BGT, was related to smoking status. Further, when considered in a logistic regression analysis, only the Sensation Seeking total score and the BART score contributed uniquely to the differentiation of smokers and nonsmokers.

Exploring social desirability bias

Abstract: This study examines social desirability bias in the context of ethical decision-making by accountants. It hypothesizes a negative relation between social desirability bias and ethical evaluation. It also predicts an interaction effect between religiousness and gender on social desirability bias. An experiment using five general business vignettes was carried out on 121 accountants (63 males and 58 females). The results show that social desirability bias is higher (lower) when the situation encountered is more (less) unethical. The bias has religiousness and gender main effects as well as an interaction effect between these two independent variables. Women who were more religious recorded the highest bias scores relative to less religious women and men regardless of their religiousness.

Critical Evidence A Test of the Critical-Period Hypothesis for Second-Language Acquisition

Abstract: The critical-period hypothesis for second-language acqui- sition was tested on data from the 1990 U.S. Census using responses from 2.3 million immigrants with Spanish or Chinese language back- grounds. The analyses tested a key prediction of the hypothesis, namely, that the line regressing second-language attainment on age of immigration would be markedly different on either side of the critical- age point. Predictions tested were that there would be a difference in slope, a difference in the mean while controlling for slope, or both. The results showed large linear effects for level of education and for age of immigration, but a negligible amount of additional variance was accounted for when the parameters for difference in slope and difference in means were estimated. Thus, the pattern of decline in second-language acquisition failed to produce the discontinuity that is an essential hallmark of a critical period.

Focusing on Value: Reconciling Corporate Social Responsibility, Sustainability and a Stakeholder Approach in a Network World

Abstract: David Wheeler is Erivan K. Haub Professor and Barry Colbert is Senior Research Fellow in the Business and Sustainability Programme in the Schulich School of Business, York University, Toronto, Canada. R. Edward Freeman is the Elis and Signe Olsson Professor of Business Administration and Director of the Olsson Centre for Applied Ethics in the Darden School of Business, University of Virginia, Charlottesville, USA. Focusing on Value: Reconciling Corporate Social Responsibility, Sustainability and a Stakeholder Approach in a Network World

Geomorphic controls on hyporheic exchange flow in mountain streams

Abstract: [1] Hyporheic exchange flows were simulated using MODFLOW and MODPATH to estimate relative effects of channel morphologic features on the extent of the hyporheic zone, on hyporheic exchange flow, and on the residence time of stream water in the hyporheic zone. Four stream reaches were compared in order to examine the influence of stream size and channel constraint. Within stream reaches, the influence of pool-step or pool-riffle sequences, channel sinuosity, secondary channels, and channel splits was examined. Results showed that the way in which channel morphology controlled exchange flows differed with stream size and, in some cases, with channel constraint. Pool-step sequences drove hyporheic exchange in the second-order sites, creating exchange flows with relatively short residence times. Multiple features interacted to drive hyporheic exchange flow in the unconstrained fifth-order site, where pool-riffle sequences and a channel split created exchange flows with short residence times, whereas a secondary channel created exchange flows with long residence times. There was relatively little exchange flow in the bedrock-constrained fifth-order site. Groundwater flow models were effective in examining the morphologic features that controlled hyporheic exchange flow, and surface-visible channel morphologic features controlled the development of the hyporheic zone in these mountain streams.

The interpersonal expression of perfection: perfectionistic self-presentation and psychological distress

Abstract: A concept involving the interpersonal expression of perfection, perfectionistic self-presentation, is introduced. It is argued that perfectionistic self-presentation is a maladaptive self-presentational style composed of three facets: perfectionistic self-promotion (i.e., proclaiming and displaying one's perfection), nondisplay of imperfection (i.e., concealing and avoiding behavioral demonstrations of one's imperfection), and nondisclosure of imperfection (i.e., evading and avoiding verbal admissions of one's imperfection). Several studies involving diverse samples demonstrate that perfectionistic self-presentation is a valid and reliable construct and a consistent factor in personal and interpersonal psychological distress. It is argued that the need to promote one's perfection or the desire to conceal one's imperfection involves self-esteem regulation in the interpersonal context.

Developing phonological awareness: Is there a bilingual advantage?

Abstract: Three studies are reported that examine the development of phonological awareness in monolingual and bilingual children between kindergarten and Grade 2. In the first study, monolingual and bilingual children performed equally well on a complex task requiring phoneme substitution. The second study replicated these results and demonstrated a significant role for the language of literacy instruction. The third study extended the research by including two groups of bilingual children and a range of phonological awareness and reading tasks. Spanish–English bilinguals performed better than English-speaking monolinguals on a phoneme segmentation task, but Chinese–English bilinguals performed worse. Other measures of phonological awareness did not differ among the three groups. The results are discussed in terms of a limit on the effect that bilingualism exerts on metalinguistic development.

Metrics for text entry research: an evaluation of MSD and KSPC, and a new unified error metric

Abstract: We describe and identify shortcomings in two statistics recently introduced to measure accuracy in text entry evaluations: the minimum string distance (MSD) error rate and keystrokes per character (KSPC). To overcome the weaknesses, a new framework for error analysis is developed and demonstrated. It combines the analysis of the presented text, input stream (keystrokes), and transcribed text. New statistics include a unified total error rate, combining two constituent error rates: the corrected error rate (errors committed but corrected) and the not corrected error rate (errors left in the transcribed text). The framework includes other measures including error correction efficiency, participant conscientiousness, utilised bandwidth, and wasted bandwidth. A text entry study demonstrating the new methodology is described.

Neurophenomenology Integrating Subjective Experience and Brain Dynamics in the Neuroscience of Consciousness

Abstract: The paper presents a research programme for the neuroscience of con- sciousness called 'neurophenomenology' (Varela 1996) and illustrates it with a recent pilot study (Lutz et al., 2002). At a theoretical level, neurophenomenology pursues a n e mbodied a nd l arge-scale d ynamical a pproach t o t he neurophysiology of consciousness (Varela 1995; Thompson and Varela 2001; Varela and Thompson 2003). At a methodological level, the neurophenomeno- logical strategy is to make rigorous and extensive use of first-person data about subjective experience as a heuristic to describe and quantify the large-scale neurodynamics of consciousness (Lutz 2002). The paper foocuses on neurophenomenology in relation to three challenging methodological issues about incorporating first-person data into cognitive neuroscience: (i) first-person reports can be biased or inaccurate; (ii) the process of generating first-person reports about an experience can modify that experience; and (iii) there is an 'ex- planatory gap' in our understanding of how to relate first-person, phenomeno- logical data to third-person, biobehavioural data.

Profitability of small- and medium-sized enterprises in high-tech industries: the case of the biotechnology industry

Abstract: This paper investigates the profitability determinants of small- and medium-sized enterprises in high-tech industries. Literature review suggests that innovator position, market awareness, niche operation, and internationalization should have positive impacts on SMTEs' profitability. However, the empirical results partially agree with, and partially dissent from, the propositions. Copyright © 2003 John Wiley & Sons, Ltd.

PPARγ coactivator-1α expression during thyroid hormone-and contractile activity-induced mitochondrial adaptations

Abstract: The transcriptional coactivator the peroxisome proliferator-activated receptor γ coactivator-1α (PGC-1α) has been identified as an important mediator of mitochondrial biogenesis based on its abilit...

ARC1 is an E3 ubiquitin ligase and promotes the ubiquitination of proteins during the rejection of self-incompatible Brassica pollen.

Abstract: ARC1 is a novel U-box protein required in the Brassica pistil for the rejection of self-incompatible pollen; it functions downstream of the S receptor kinase (SRK). Here, we show that ARC1 has E3 ubiquitin ligase activity and contains several motifs that influence its subcellular localization. ARC1 can shuttle between the nucleus, cytosol, and proteasome/COP9 signalosome (CSN) when expressed in tobacco BY-2 suspension-cultured cells. However, ARC1 localization to the proteasome/CSN occurs only in the presence of an active SRK. In the pistil, ubiquitinated protein levels increase specifically with incompatible pollinations, but they do not change in ARC1 antisense-suppressed pistils. In addition, inhibition of the proteasomal proteolytic activity disrupts the self-incompatibility response. We propose that ARC1 promotes the ubiquitination and proteasomal degradation of compatibility factors in the pistil, which in turn leads to pollen rejection.

Ecology and Control of Introduced Plants

Abstract: The global spread of plant species by humans is both a fascinating large scale experiment and, in many cases, a major perturbation to native plant communities Many of the most destructive weeds today have been intentionally introduced to new environments where they have had unexpected and detrimental impacts This 2003 book considers the problem of invasive introduced plants from historical, ecological and sociological perspectives We consider such questions as 'What makes a community invasible?', 'What makes a plant an invader?' and 'Can we restore plant communities after invasion?' Written with advanced students and land managers in mind, this book contains practical explanations, case studies and an introduction to basic techniques for evaluating the impacts of invasive plants An underlying theme is that experimental and quantitative evaluation of potential problems is necessary, and solutions must consider the evolutionary and ecological constraints acting on species interactions in newly invaded communities

Gender Equality and Long-Run Growth

Abstract: This research suggests that long-run economic and demographic development in Europe can be better understood when related to long-term trends in gender equality, dating back to the spread of Christianity. We set up a growth model where gaps in female-to-male human capital arise at equilibrium through a coordination process. An economy which over a long stretch of time re-coordinates on continuously more equal equilibria—as one could argue happened in Europe—exhibits growth patterns qualitatively similar to that of Europe.

How does direct-to-consumer advertising (DTCA) affect prescribing? A survey in primary care environments with and without legal DTCA

Abstract: Background: Direct-to-consumer advertising (DTCA) of prescription drugs has increased rapidly in the United States during the last decade, yet little is known about its effects on prescribing decisions in primary care. We compared prescribing decisions in a US setting with legal DTCA and a Canadian setting where DTCA of prescription drugs is illegal, but some cross-border exposure occurs. Methods: We recruited primary care physicians working in Sacramento, California, and Vancouver, British Columbia, and their group practice partners to participate in the study. On preselected days, patients aged 18 years or more completed a questionnaire before seeing their physician. We asked these patients’ physicians to complete a brief questionnaire immediately following the selected patient visit. By pairing individual patient and physician responses, we determined how many patients had been exposed to some form of DTCA, the frequency of patients’ requests for prescriptions for advertised medicines and the frequency of prescriptions that were stimulated by the patients’ requests. We measured physicians’ confidence in treatment choice for each new prescription by asking them whether they would prescribe this drug to a patient with the same condition. Results: Seventy-eight physicians (Sacramento n = 38, Vancouver n = 40) and 1431 adult patients (Sacramento n = 683, Vancouver n = 748), or 61% of patients who consulted participating physicians on pre-set days, participated in the survey. Exposure to DTCA was higher in Sacramento, although 87.4% of Vancouver patients had seen prescription drug advertisements. Of the Sacramento patients, 7.2% requested advertised drugs as opposed to 3.3% in Vancouver (odds ratio [OR] 2.2, 95% confidence interval [CI] 1.2–4.1). Patients with higher selfreported exposure to advertising, conditions that were potentially treatable by advertised drugs, and/or greater reliance on advertising requested more advertised medicines. Physicians fulfilled most requests for DTCA drugs (for 72% of patients in Vancouver and 78% in Sacramento); this difference was not statistically significant. Patients who requested DTCA drugs were much more likely to receive 1 or more new prescriptions (for requested drugs or alternatives) than those who did not request DTCA drugs (OR 16.9, 95% CI 7.5–38.2). Physicians judged 50.0% of new prescriptions for requested DTCA drugs to be only “possible” or “unlikely” choices for other similar patients, as compared with 12.4% of new prescriptions not requested by patients (p < 0.001). Interpretation: Our results suggest that more advertising leads to more requests for advertised medicines, and more prescriptions. If DTCA opens a conversation between patients and physicians, that conversation is highly likely to end with a prescription, often despite physician ambivalence about treatment choice.

Which treatment for whom for ADHD? Moderators of treatment response in the MTA

Abstract: Using receiver operating characteristics, the authors examined outcome predictors (variables associated with outcome regardless of treatment) and moderators (variables identifying subgroups with differential treatment effectiveness) in the Multimodal Treatment Study of Children with Attention-Deficit/Hyperactivity Disorder (ADHD; MTA). Treatment response was determined using parent- and teacher-reported ADHD and oppositional defiant symptoms, with levels near or within the normal range indicating excellent response. Among 9 baseline child and family characteristics, none predicted but 3 moderated treatment response. In medication management and combined treatments, parental depressive symptoms and severity of child ADHD were associated with decreased rates of excellent response; when these 2 characteristics were present, below-average child IQ was an additional moderator. No predictors or moderators emerged for behavioral and community comparison treatments. The authors discuss conceptual and clinical implications of research on treatment moderators.

Review of mesospheric temperature trends

Abstract: In recent times it has become increasingly clear that releases of trace gases from human activity have a potential for causing change in the upper atmosphere. However, our knowledge of systematic changes and trends in the temperature of the mesosphere and lower thermosphere is relatively limited compared to the Earths lower atmosphere, and not much effort has been made to synthesize these results so far. In this article, a comprehensive review of long-term trends in the temperature of the region from 50 to 100 km is made on the basis of the available up-to-date understanding of measurements and model calculations. An objective evaluation of the available data sets is attempted, and important uncertainly factors are discussed. Some natural variability factors, which are likely to play a role in modulating temperature trends, are also briefly touched upon. There are a growing number of experimental results centered on, or consistent with, zero temperature trend in the mesopause region (80–100 km). The most reliable data sets show no significant trend but an uncertainty of at least 2 K/decade. On the other hand, a majority of studies indicate negative trends in the lower and middle mesosphere with an amplitude of a few degrees (2–3 K) per decade. In tropical latitudes the cooling trend increases in the upper mesosphere. The most recent general circulation models indicate increased cooling closer to both poles in the middle mesosphere and a decrease in cooling toward the summer pole in the upper mesosphere. Quantitatively, the simulated cooling trend in the middle mesosphere produced only by CO 2 increase is usually below the observed level. However, including other greenhouse gases and taking into account a “thermal shrinking” of the upper atmosphere result in a cooling of a few degrees per decade. This is close to the lower limit of the observed nonzero trends. In the mesopause region, recent model simulations produce trends, usually below 1 K/decade, that appear to be consistent with most observations in this region

The SuperSID project: exploiting high-level information for high-accuracy speaker recognition

Abstract: The area of automatic speaker recognition has been dominated by systems using only short-term, low-level acoustic information, such as cepstral features. While these systems have indeed produced very low error rates, they ignore other levels of information beyond low-level acoustics that convey speaker information. Recently published work has shown examples that such high-level information can be used successfully in automatic speaker recognition systems and has the potential to improve accuracy and add robustness. For the 2002 JHU CLSP summer workshop, the SuperSID project (http://www.clsp.jhu.edu/ws2002/groups/supersid/) was undertaken to exploit these high-level information sources and dramatically increase speaker recognition accuracy on a defined NIST evaluation corpus and task. The paper provides an overview of the structure, data, task, tools, and accomplishments of this project. Wide ranging approaches using pronunciation models, prosodic dynamics, pitch and duration features, phone streams, and conversational interactions were explored and developed. We show how these novel features and classifiers indeed provide complementary information and can be fused together to drive down the equal error rate on the 2001 NIST extended data task to 0.2% - a 71% relative reduction in error over the previous state of the art.

Identifying and Targeting Risk for Involvement in Bullying and Victimization

Abstract: Bullying is a relationship problem in which power and aggression are used to cause distress to a vulnerable person. To assess and address bullying and victimization, we need to understand the nature of the problem, how the problem changes with age and differs for boys and girls, the relevant risk factors (those individual or environmental indicators that may lead to bullying and victimization), and the protective factors that buffer the impact of risk. For children involved in bullying, we need to assess its extent and the associated social, emotional, psychological, educational, and physical problems. Bullying is a systemic problem; therefore, assessments of bullying need to extend beyond the individual child to encompass the family, peer group, school, and community. We recommend that assessments at each of these levels reflect the scientific research on bullying and victimization. With attention to the problems associated with bullying, we can work collectively to make schools and communities safer for children and youth.

Negative facial expression captures attention and disrupts performance.

Abstract: In two experiments, participants counted features of schematic faces with positive, negative, or neutral emotional expressions. In Experiment 1 it was found that counting features took longer when they were embedded in negative as opposed to positive faces. Experiment 2 replicated the results of Experiment 1 and also demonstrated that more time was required to count features of negative relative to neutral faces. However, in both experiments, when the faces were inverted to reduce holistic face perception, no differences between neutral, positive, and negative faces were observed, even though the feature information in the inverted faces was the same as in the upright faces. We suggest that, relative to neutral and positive faces, negative faces are particularly effective at capturing attention to the global face level and thereby make it difficult to count the local features of faces.