York University

About: York University is a education organization based out in Toronto, Ontario, Canada. It is known for research contribution in the topics: Population & Poison control. The organization has 18899 authors who have published 43357 publications receiving 1568560 citations.

The neurotic citizen

Abstract: Over the last three decades we have witnessed the birth of a subject that has constituted the foundations of a regime change in state societies: the neoliberal subject. As much as neoliberalism came to mean the withdrawal of the state from certain arenas, the decline of social citizenship, privatization, downloading, and so forth, it also meant, if not predicated upon, the production of an image of the subject as sufficient, calculating, responsible, autonomous, and unencumbered. While the latter point has been a topic of debate concerning the rational subject, I wish to argue that the rational subject has itself been predicated upon and accompanied by another subject: the neurotic subject. More recently, it is this neurotic subject that has become the object of various governmental projects whose conduct is based not merely on calculating rationalities but also arises from and responds to fears, anxieties and insecurities, which I consider as ‘governing through neurosis’. The rise of the neurotic citizen...

The time course and chromosomal localization of recombination-related proteins at meiosis in the mouse are compatible with models that can resolve the early DNA-DNA interactions without reciprocal recombination.

Abstract: During mouse meiosis, the early prophase RAD51/DMC1 recombination protein sites, which are associated with the chromosome cores and which serve as markers for ongoing DNA-DNA interactions, are in ten-fold excess of the eventual reciprocal recombinant events. Most, if not all, of these early interactions are eliminated as prophase progresses. The manner in which these sites are eliminated is the focus of this investigation. We report that these sites acquire replication protein A, RPA and the Escherichia coli MUTS homologue, MSH4p, and somewhat later the Bloom helicase, BLM, while simultaneously losing the RAD51/DMC1 component. Eventually the RPA component is also lost and BLM sites remain. At that time, the MUTL homologue, MLH1p, which is essential for reciprocal recombination in the mouse, appears in numbers and locations that correspond to the distribution of reciprocal recombination events. However, the MLH1 foci do not appear to coincide with the remaining BLM sites. The MLH1p is specifically localized to electron-microscope-defined recombination nodules. We consider the possibility that the homology-search RAD51/DMC1 complexes are involved in homologous chromosome synapsis but that most of these early DNA-DNA interactions are later resolved by the anti-recombination RPA/MSH4/BLM-topoisomerase complex, thereby preventing the formation of superfluous reciprocal recombinant events.