Institution
Zhejiang Gongshang University
Education•Hangzhou, China•
About: Zhejiang Gongshang University is a education organization based out in Hangzhou, China. It is known for research contribution in the topics: Computer science & Chemistry. The organization has 8258 authors who have published 7670 publications receiving 90296 citations. The organization is also known as: Zhèjiāng Gōngshāng Dàxué.
Topics: Computer science, Chemistry, Adsorption, Catalysis, China
Papers published on a yearly basis
Papers
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TL;DR: A review of the application of food hydrocolloids, mainly proteins and polysaccharides, for modulating the gastrointestinal fate of functional foods, with an emphasis on their ability to control macronutrient digestion and bioactive bioavailability, is provided in this paper.
50 citations
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TL;DR: The chemical structures of the two flavonoid glycosides were confirmed by electrospray ionization ion trap multiple mass spectrometry and nuclear magnetic resonance experiments.
50 citations
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TL;DR: The results showed that an increased C/N ratio helped the BES to remove nitrate and depress nitrite accumulation but did not increase autotrophic denitrification.
50 citations
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TL;DR: Wang et al. as discussed by the authors found that SARS-CoV-2 infection triggers an incomplete autophagy response, elevated autophagosome formation but impaired autophagome maturation.
Abstract: Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) is the causative agent for the coronavirus disease 2019 (COVID-19) pandemic and there is an urgent need to understand the cellular response to SARS-CoV-2 infection. Beclin 1 is an essential scaffold autophagy protein that forms two distinct subcomplexes with modulators Atg14 and UVRAG, responsible for autophagosome formation and maturation, respectively. In the present study, we found that SARS-CoV-2 infection triggers an incomplete autophagy response, elevated autophagosome formation but impaired autophagosome maturation, and declined autophagy by genetic knockout of essential autophagic genes reduces SARS-CoV-2 replication efficiency. By screening 26 viral proteins of SARS-CoV-2, we demonstrated that expression of ORF3a alone is sufficient to induce incomplete autophagy. Mechanistically, SARS-CoV-2 ORF3a interacts with autophagy regulator UVRAG to facilitate PI3KC3-C1 (Beclin-1-Vps34-Atg14) but selectively inhibit PI3KC3-C2 (Beclin-1-Vps34-UVRAG). Interestingly, although SARS-CoV ORF3a shares 72.7% amino acid identity with the SARS-CoV-2 ORF3a, the former had no effect on cellular autophagy response. Thus, our findings provide the mechanistic evidence of possible takeover of host autophagy machinery by ORF3a to facilitate SARS-CoV-2 replication and raise the possibility of targeting the autophagic pathway for the treatment of COVID-19.
50 citations
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TL;DR: Strong correlations were found between the residual DMP, DBP concentrations and the biologically degradable material (BDM) of the refuse and PAEs degraded more rapidly in the landfill that was operated in conjunction with the methanogenic reactor when compared to the landfill with direct leachate discharge.
50 citations
Authors
Showing all 8318 results
Name | H-index | Papers | Citations |
---|---|---|---|
David Julian McClements | 131 | 1137 | 71123 |
Sajal K. Das | 85 | 1124 | 29785 |
Ye Wang | 85 | 466 | 24052 |
Xun Wang | 84 | 606 | 32187 |
Tao Jiang | 82 | 940 | 27018 |
Yueming Jiang | 79 | 452 | 20563 |
Mo Wang | 61 | 274 | 13664 |
Robert J. Linhardt | 58 | 1190 | 53368 |
Jiankun Hu | 57 | 493 | 11430 |
Xuming Zhang | 56 | 384 | 10788 |
Yuan Li | 50 | 352 | 8771 |
Chunping Yang | 49 | 173 | 8604 |
Duo Li | 48 | 329 | 9060 |
Matthew Campbell | 48 | 236 | 13448 |
Aiqian Ye | 48 | 163 | 6120 |