Showing papers in "Acta Biomaterialia in 2016"

TL;DR: This review discusses and summarizes recent advancements in processing SF, focusing on different fabrication and functionalization methods and their application to grow bone tissue in vitro and in vivo, which provides an impressive toolbox and allows silk fibroin scaffolds to be tailored to specific applications.

TL;DR: It is demonstrated that macrophages cultured on high surface wettability materials produce an anti-inflammatory microenvironment, and this property may be used to improve the healing response to biomaterials.

TL;DR: This research is the first to demonstrate the occurrence of bone ingrowth into high-strength porous biomaterials which have higher structural efficiency than current porous biommaterials in the market, and it is shown that they encourage bone ing growth in a canine model.

TL;DR: This review summarizes the antifouling mechanisms of zwitterionic materials inspired by cell membranes as well as the popular approaches to incorporate them onto membrane surfaces to form a comprehensive knowledge about the principles and methods of modifying membrane surfaces with zwatterionic materials.

TL;DR: This review provides overview of the advances in silk protein-based hydrogels with a primary emphasis on hydrogel of fibroin with the aim of highlighting the research that has been done in the area of silk-basedHydrogels.

TL;DR: The entire novel process that can be followed to design graded porous implants, whatever its external shape and geometry, but internally tuned to the exact histomorphometric indices needed to match natural human tissues microstructures and, consequently, their mechanical and fluid properties, among others are shown.

TL;DR: The present work reviewed the recent developments and advances of biomedical BMGs, including Ti- based, Zr-based, Fe-based and Mg-based BMG alloying systems, and the possible solution to the BMG size limitation, the brittleness of B MGs has been proposed.

TL;DR: Recent progress is reviewed on how to control the degrdation rate based on the relevant corrosion mechanisms through the design of porous structure, phase structure, grains, and amorphous structure as well as surface modification, which will be beneficial to the better understanding and functional design of Mg-based scaffolds for wide clinical applications in tissue reconstruction in near futures.

TL;DR: PEGylated PAMAM-mediated delivery could not only overcome the limitations of dendrimer such as drug leakage, immunogenicity, hemolytic toxicity, systemic cytotoxicity but they also have the ability to enhance the solubilization of hydrophobic drugs and facilitates the potential for DNA transfection, siRNA delivery and tumor targeting.

TL;DR: Current tools, technologies, and approaches to design integrated and effective growth factor-based therapies for regenerative medicine applications, including elegant biomaterial-based systems inspired by the natural extracellular matrix milieu, are highlighted.

TL;DR: The synthesized conductive hybrid hydrogels properly accommodated cardiac cells and subsequently resulted in excellent cell retention, spreading, homogeneous distribution of cardiac specific markers, cell-cell coupling as well as robust synchronized beating behavior.

TL;DR: Mechanical tailoring of dECM bioink by using vitamin B2 and UVA irradiation is described, which could fabricate a bioconstruct that has stiffness similar to that of the target tissue.

TL;DR: The results indicate that Cu(2+) ions released from Cu-BG/ESM nanocomposite films play an important role for improving both angiogenesis and antibacterial activity and the prepared nanocomPOSite films combined Cu-containing BG nanocoatings with ESM are a promising biomaterial for wound healing application.

TL;DR: Results suggest docetaxel (DTX)-loaded formulations using polydopamine-modified NPs synthesized from D-α-tocopherol polyethylene glycol 1000 succinate-poly(lactide) (pD-TPGS-PLA/NPs) may be used as a potentially eligible drug delivery system targeting liver cancers.

TL;DR: This review gives a comprehensive overview on the taxonomy of the currently known macrophage subtypes, with a lack on a good summary on the current taxonomy, functions and phenotypes of macrophages in my recent projects on the biocompatibility of biomaterials in the mouse model.

TL;DR: The GO coating improved several biomedical properties of the aligned PLLA nanofibrous scaffolds including surface roughness, hydrophilicity and promotion of cells/material interactions, which significantly promoted SCs growth and regulated cell orientation, and induced PC12 cells differentiation and neurite outgrowth.

TL;DR: This review points out the great potential carried by hierarchical bioactive glass scaffolds that exhibit pore scales from the meso- to the macro-range, and their impact in the broad field of tissue engineering, including the emerging applications in contact with soft tissues and diagnostics.

TL;DR: Results suggest that the novel Cu-MSNs could be used as an immunomodulatory agent with osteostimulatory capacity for bone regeneration/therapy application and introduces controllable amount of therapeutic ions instead of loading expensive drugs/growth factors in mesoporous silica nanosphere.

TL;DR: A mussel-inspired easy-to-use double-crosslink tissue adhesive comprising a dopamine-conjugated gelatin macromer, a rapid crosslinker, and a long-term acting crosslinkers that exhibits significantly higher wet tissue adhesion capability than the commercially available fibrin glue when applied on wet porcine skin and cartilage.

TL;DR: TMS/rhBMP-2 developed here represents a promising bone substitute for clinical application and the concepts proposed in this study might provide new thoughts on development of future orthopedic biomaterials.

TL;DR: The study indicates that myelin might play a more important function than previously thought: It not only insulates signal propagation and improves electrical function of single axons, it also provides structural support and mechanical stiffness to the brain as a whole.

TL;DR: It is suggested that a Cys-KR12-immobilized SF nanofiber membrane, which has multiple biological activities, would be a promising candidate as a wound dressing material, and the immobilized peptide can play multi-role in wound healing process.

TL;DR: Recent avenues for nanomaterials in multimodal and multifunctional molecular imaging are revealed through a review of pertinent literatures which will be helpful in a way to plan, understand and lead the nanotechnology related work.

TL;DR: An in-depth look at polysaccharide-based antibiofilm surfaces that have been proposed over the last ten years is taken, which is a novelty compared to published literature, and will bring well documented and updated information to readers of Acta Biomaterialia.

TL;DR: The new tri-axial electrospinning process developed in this work provides a platform to fabricate structural nanomaterials, and the core-shell polymer-PL nanocomposites produced have significant potential applications for oral colon-targeted drug delivery.

TL;DR: A multi-layer collagen-based osteochondral defect repair scaffold designed to direct host-stem cell mediated tissue formation within each region shows the potential of this biomimetic multi-layered scaffold to support and guide the host reparative response in the treatment of oste mitochondral defects.

TL;DR: A bio-active scaffold is designed using a very simple and direct method to manufacture DOPA coated 3D PCL porous scaffold grafted with recombinant human bone morphogenic protein-2 (rhBMP2) attached via polydopamine (DOPA) chemistry.

TL;DR: A novel composite scaffold fabricated by co-electrospinning of poly-ε-caprolactone (PCL) microfibers and methacrylated gelatin (mGLT) is developed as a tendon graft and will allow the creation of a more advanced tendon graft that possesses the architecture and cell phenotype of native tendon tissues.

TL;DR: Interestingly, osteoblasts cultured within hydrogel using bone morphogenetic protein (BMP)-2 demonstrated the capability for encapsulation of cells and induced cell differentiation, and the nanocrystalline cellulose significant impacted degradation and interaction between hydrogels and cells.

TL;DR: 3D printing of biodegradable Fe alloy is anticipated to be advantageous over current bone grafting techniques and confirmed enhanced degradation of Ca addition to 3D printed constructs validating the theoretical and alloy development studies.