Showing papers in "Acta Biomaterialia in 2019"

TL;DR: In this review, the different strategies to prevent infection onto titanium and titanium alloy surfaces such as surface modification by antibiotics, antimicrobial peptides, inorganic antibacterial metal elements and antibacterial polymers are reported.

TL;DR: This review provides a brief overview of current progress in existing biomaterials and tissue engineering scaffolds prepared by 3D printing technologies, with an emphasis on the material selection, scaffold design optimization, and their preclinical and clinical applications in the repair of critical-sized bone defects.

TL;DR: An improvement in wettability and bioactivity of titanium implant surfaces has been accomplished by combining micro and nano-scale modification and functionalization with protein, peptides, and bioactive compounds.

TL;DR: This review offers an up-to-date and comprehensive review of the influence of alloying and fabrication technique on mechanical properties, biodegradability and biocompatibility of Zn.

TL;DR: A detailed discussion of the biodistribution and toxicity of quantum dots, and recent advances to improve long-term stability in biological buffers, increase quantum yield following bioconjugation, and improve clearance from the body are presented.

TL;DR: A comprehensive understanding of the properties and applications of exosomes, including their biogenesis, biofunctions, isolation, purification, and drug loading, and typical examples in drug delivery and therapy are provided.

TL;DR: A series of injectable electroactive biodegradable hydrogels with rapid self-healing ability composed of N-carboxyethyl chitosan (CECS) and dextran-graft-aniline oligomers are synthesized and demonstrated their potential application as cell delivery vehicles for skeletal muscle regeneration.

TL;DR: Evidence is laid out that polymeric nanogels have an important role to play in the design of innovative drug delivery vehicles that respond to internal and external stimuli such as temperature, pH, redox, and light.

TL;DR: This paper presents and critically evaluates the most important trends and findings in this area with a special focus on the metallic biomaterials used for skeletal applications to enable researchers better understand the current state-of-the-art and to guide the design of future research projects.

TL;DR: This study reports that THP-1 derived macrophages cultured on collagen-coated polyacrylamide gels of varying stiffness adapt their polarization state, functional roles and migration mode according to the stiffness of the underlying substrate and suggests that biomaterial stiffness is capable of directing macrophage behaviour independent of the biochemical cues being presented to them.

TL;DR: It is proposed to re-engineer immuno-exosome with a synthetic liposome as a refined biomimetic nanostructure for the delivery of doxorubicin (clinical drug) for breast cancer treatment.

TL;DR: This paper presents developments in the fundamental knowledge in polymer designs and discussions on the practical biomedical application of the materials, which sheds more light on the advancement of injectable self-healing hydrogels.

TL;DR: The current knowledge regarding the eventual structural organisation of the bone-implant interface is reviewed, with a focus on solid devices intended for permanent anchorage in bone, and certain biomaterials that undergo surface and bulk degradation.

TL;DR: The study clearly demonstrated the capabilities of combined experimental and computational methods to resolve the uncertainties of the mechanical behavior of FGPBs, which would open up the possibilities of applying various porosity variation strategies for the design of biomimetic AM porous biomaterials.

TL;DR: The fabrication and mechanical characterization of porous poly(ε-caprolactone) and PCL-hydroxyapatite scaffolds with incorporated vertical porosity and ceramic content gradients via a multimaterial extrusion 3DP system is described and will serve as the template for more complex multimaterial constructs with bioactive cues that better match native tissue physiology and promote tissue regeneration.

TL;DR: It is suggested that MSC exosome is a viable ready-to-use and cell-free MSC therapeutic for the treatment of periodontal defects and demonstrated for the first time that M SC exosomes enhance periodontAL regeneration possibly by increasing PDL migration and proliferation.

TL;DR: The significance of 4D printing in biomedical applications is demonstrated, in which "time" has been incorporated into the conventional concept of 3D printing as the 4th dimension.

TL;DR: This review introduces the development history and current status of AM of biodegradable metals and critically surveys L-PBF of Mg-, Fe-, and Zn-based metals from multiple viewpoints including materials, processing, formation quality, structural design, microstructure, and mechanical and biological properties.

TL;DR: This review provides the most recent progress in the development of absorbable Zn-based alloys for biomedical implant applications, primarily for cardiovascular and orthopedic devices and summarizes the research advances to date.

TL;DR: Graphene-based conductive nanofibrous scaffolds are explored with the possibility of combining the conductive properties of graphene with electrospun nanofiber to create the electroactive biomimetic scaffolds for nerve tissue regeneration.

TL;DR: Common considerations such as strength, ductility, and fatigue behaviors are covered together with special attention on several new uncertainties including low creep resistance, high susceptibility to natural aging, and static recrystallization (SRX) which may lead to device failure during storage at room temperature and clinical usage at body temperature.

TL;DR: Identifying the effective range of dimensions in terms of height, diameter, and interspacings, as well as covering their impact on mammalian cells, has enabled a comprehensive discussion including the bactericidal mechanisms and the factors controlling the bactericides efficiency.

TL;DR: This work presented a simple and efficient strategy to prepare a 3D biomimetic core-shell scaffold based on electrospun aligned conductive nanofiber yarns within photocurable hydrogel shell to mimic the hierarchically aligned structure of native nerve tissue.

TL;DR: This review is intended to provide the readers a comprehensive background of the vast literature till date on silica-based drug delivery systems, and to inspire further innovations in silica nanomedicine in the future.

TL;DR: This paper is part 2 of a series of 4 reviews discussing the problem of biomaterial associated thrombogenicity to highlight features of broad agreement and provide commentary on those aspects of the problem that were subject to dispute.

TL;DR: All three types of CeO 2-modified Ti exerted equally strong antibacterial properties; nano-octahedron CeO2- modified Ti had the best anti-inflammation effects.

TL;DR: A conceptual bio-engineering design methodology for new biomedical lattices produced by additive manufacturing is presented, which addresses some of the critical points in currently existing porous implant materials, including feasibility and accuracy of manufacturing, design to the elastic properties of bone, and sensible pores sizes for osseointegration.

TL;DR: Administration of CS/β-GP/gelatin hydrogels loaded with aspirin/EPO could terminate the inflammation and recover the height of the alveolar bone, which is indicated to provide a great potential candidate for periodontitis treatment in the dental clinic.

TL;DR: ZnP coating on Zn-based biomaterial appears to be a viable approach to enhance its biocompatibility and antibacterial property as well as to control its degradation rate.

TL;DR: This article comprehensively reviews the advances in nano-scale delivery vehicles designed to overcome the delivery barriers in the joint, and is the first review to analyze active and passive targeting strategies systematically for different target sites while also delineating between tissue homing and whole joint retention.