Acta Radiologica 

About: Acta Radiologica is an academic journal published by SAGE Publishing. The journal publishes majorly in the area(s): Magnetic resonance imaging & Angiography. It has an ISSN identifier of 0284-1851. Over the lifetime, 10551 publications have been published receiving 163919 citations.

Catheter replacement of the needle in percutaneous arteriography; a new technique.

Abstract: The catheter method of angiography has become more popular in the past few years, as it provides the following advantages over the method of injecting the contrast medium by means of a simple needle: 1. The contrast medium may be injected into a vessel at any level desired. 2. Risk of extravascular injection of the contrast medium is minimised. 3. The patient may be placed in any position required. 4. The catheter may be left in situ without risk while the films are being developed, thus facilitating re-examination if necessary. Until recently, however, the use of the catheter method was restricted because of the lack of a suitable flexible thin-walled catheter which could be

Studies on the distribution and fate of S35-labelled benzylpenicillin in the body.

Abstract: The aim of this investigation was to study some of the pharmacologie properties of penicillin; how it is distributed from the blood to different body tissues and how it is bound, inactivated and excreted. In order that penicillin shall exert its antibacterial activity in the body it must come into contact with the pathogenic microbes and its concentration in the immediate vicinity of these must be sufficiently high. A careful study of the distribution pattern in both normal and pathologically changed tissues is therefore of therapeutic interest. Biosynthetically prepared penicillin containing the radioisotope S has been pre­ pared and its distribution studied with autoradiographic technique. The culture and extraction methods employed in the preparation of S-labelled benzylpenicillin are described and general problems connected with the biosynthesis of radiopenicillin discussed. The autoradiographic technique was adapted to the requirements imposed by the water solubility of penicillin and also to the desire to obtain survey pictures e. g. of whole mice. Experiences of freeze-drying technique compared to freeze-room sectioning are also discussed. The varying density of large histologie survey sections of whole mice was investigated with quantitative betaradiography. This investigation formed the basis for calculation of self-absorption of the radiation from a section. Survey autoradiographs illustrating the distribution of penicillin in adult mice at different times after intravenous injection are given. Large survey autoradiographs of pregnant animals permitted studies of tracer distribution in the foetus and foetal fluids in the same picture as the mother. Detail autoradiographs are shown illustrating the distribution of penicillin in regions of special clinical interest such as the brain, eye, sinuses of the skull, nasal conchae, teeth and paradental tissues, synovial cavities, skin, bone-marrow, mammary glands, and postparturiant uterus. The autoradiographic investigation also provided possibilities of studying the dif­ ferent ways of excretion as well as the problem of accumulation in the organs. Some autoradiographic observations were also made on the penetration of penicillin into abscesses and dry necroses. (In the cases investigated penicillin passed the abscess membrane but the further diffusion towards the centre of the abscess was very unsatis­ factory in the chronic cases. The penicillin penetrated very poorly into dry necrotic areas.) Geiger-Müller counter measurements were used to study the penetration of penicillin into blood and carcinoma cells, its binding to plasma proteins, and its volume of distri­ bution in the body. A paper electrophoretic investigation of urine from animals treated with radioactive penicillin showed the presence of two radioactive components. The major component had the same mobility as penicillin and was biologically active. The smaller component with a higher mobility was biologically inactive. I ts rate of migration corresponded with that of S-penicilloic acid prepared in vitro by the inactivation of S-penicillin. The distribution of penicilloic acid in the body showed no obvious variations from the distribution of penicillin according to survey autoradiographs. Autoreview.

Histologic classification and grading of malignancy in carcinoma of the larynx.

Abstract: (1973). Histologic Classification and Grading of Malignancy in Carcinoma of the Larynx. Acta Radiologica: Therapy, Physics, Biology: Vol. 12, No. 1, pp. 1-8.

Peripheral Arterial Disease

Abstract: Purpose: To determine whether contrast-enhanced 3D MR angiography (CE MRA) could replace digital subtraction angiography (DSA) for the evaluation of atherosclerotic peripheral vascular disease of the lower leg and foot. Material and Methods: Thirty-five patients with symptoms of atherosclerotic disease of the leg were examined prospectively with CE MRA of the foot and the lower legs as well as with DSA from the aorta to the pedal arches. The MRA technique was focused on optimal imaging of the arteries of the foot. Results: The agreement between CE MRA and DSA for grading of stenosis was moderate to good (weighted κ-values 0.48–0.80). The sensitivity of CE MRA for detection of significant stenosis (≥50%) was 92% and the specificity was 64% with DSA as gold standard. Conclusion: CE MRA is a fairly accurate method for the demonstration of atherosclerotic disease below the knee including the pedal arches. It can replace DSA for the assessment of distal arteries in patients with impaired renal function. However, image quality and resolution still needs to be improved before CE MRA can become the method of choice in all patients.