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Showing papers in "Advanced Drug Delivery Reviews in 1987"


Journal ArticleDOI
E. Tomlinson1
TL;DR: The rationale for site-specific drug delivery in terms of disease and drug and carrier properties is examined, and the biological constraints and opportunities are examined by considering carrier access, retention and ability to control the timing of drug availability at site(s of action(s).

142 citations


Journal ArticleDOI
TL;DR: Various strategies for overcoming barriers which combine to present modern effective drug delivery with formidable problems have been suggested, including localization of dosage form in regions of the GI tract where protease activity is minimal.

98 citations


Journal ArticleDOI
TL;DR: The data on natural and synthetic carriers used for enzyme immobilisation, chemistry of enzyme binding, in vitro and in vivo properties of immobilised enzymes as well as their clinical use are reviewed.

53 citations