Showing papers in "Advanced Drug Delivery Reviews in 1989"

TL;DR: The nature and magnitude of the penetration and enzymatic barriers to peptide and protein drug absorption are described and the effectiveness and limitations of the approaches that have been used to overcome such barriers are reviewed.

TL;DR: The utility of various drug fixation methods to provide well-defined dextran-drug conjugates with feasible delivery characteristics is discussed and it is emphasized that adequate characterization of the prepared deXTran prodrugs prior to biological evaluation is of the utmost importance.

TL;DR: The primary emphasis of the current effort is to focus on the use of antibodies as vector molecules for targeted liposome drug delivery systems, i.e., the use with direct conjugation of drug with antibody.

TL;DR: Techniques involved in generating liposomal-drug systems in a manner compatible with clinical demands are reviewed, and new techniques for the efficient and stable entrapment of drugs at high drug/lipid ratios are introduced.

TL;DR: The use of cascade latentiation or the double prodrug concept, i.e., making a prodrug of a pro drug, is suggested as a promising means of overcoming various draw backs of usual prodrugs.

TL;DR: For many of the strategies that have been described, only one or two examples were available to show the effect that implementing a particular prodrug strategy had on solubilities and hence on ability to enhance dermal delivery, so application of conclusions based on the results from the homologous series of prodrugs to these latter strategies should allow one to optimize Dermal delivery for them as well.

TL;DR: Oral drug applications based on lectins either as receptors or ligands may now be ready for experimental exploration, particularly in the damaged mucosa.

TL;DR: This review aims to examine the strengths and weaknesses of targeted drug delivery using a macromolecule-drug conjugate alone or with other therapeutic modalities and look at areas of cancer therapy where it could be of benefit.

TL;DR: Understanding of the mechanisms responsible for these pathways of intracellular sorting will enable drug-carrier design that will fully exploit the potential of hepatocyte receptor-mediated endocytosis for drug delivery.

TL;DR: The distribution and metabolism of therapeutic proteins and peptides in patients and laboratory animals and an effort is being made to devise appropriate routes of administration, dosages and regimens for improving their therapeutic index.

TL;DR: It is concluded that even when passive transport processes are involved, there appears to be a ‘size window’ of about 30–40 A for macromolecules that, because of their size cannot pass through the kidneys but will cross the normal endothelium in other organs and tissues.

TL;DR: It is necessary to check the degradation of the final drug form and assess the pharmacology and immunology of all intermediate fragments, and synthetic polymers degradable in the main chain, poly(amino acids) being the most promising type.

TL;DR: This review has taken a practical approach toward identifying those factors which must be considered to permit development of successful liposomal peptide formulations.

TL;DR: This review considers current understanding of macrophage biology within the context of the intact host and suggests avenues for selective modification of cellular activity in situ.

TL;DR: The various approaches that are being explored for development of a safe and efficacious immunological adjuvant aimed at specifically increasing both the humoral as well as cellular immune response to a desired vaccine antigen are reviewed.

TL;DR: Several cell surface proteins have now been identified as viral receptors, and analyses of intact virus particles and sub-viral components are revealing the structures of the binding determinants on the viruses themselves.

TL;DR: In this article, the authors present the principles of liquid surfactant membranes and their application to the development of a simple and effective enzyme immobilization, and give different examples of the encapsulation of enzymes in emulsions.

TL;DR: Various scientific achievements and challenges in obtaining recombinant therapeutic proteins are also elaborated in this review.

TL;DR: This review covers recent work published on liposome encapsulation of four different groups of anti- inflammatory agents, i.e., glucocorticosteroids, nonsteroidal anti-inflammatory drugs, anti-oxidant enzymes and radioisotopes.

TL;DR: Osmotic pumps will play a major role in rectal and vaginal delivery when appropriate compounds and formulations become available and the combination of osmotic energy with delivery control mechanisms should further expand their usefulness.

TL;DR: This review will illustrate this combined approach when used in conjunction with conventional chemical and biochemical approaches to fill the analytical gap between protein chemistry and molecular genetics, through examples encountered in the biopharmaceutical industry.

TL;DR: Some qualified statements about optimisation of drug targeting are made dependent on the extent of understanding of the disease process, the anatomy and pathophysiology of the target site, the pharmacokinetics of drug carrier and free drug, the mechanism of drug release and the pharmacodynamics of therapeutic and toxic effects.

TL;DR: This review will focus on the problems related to antifungal therapy with polyenes and the use of liposomes as drug carriers for polyene macrolide antibiotics alone or in combination with other drugs or biological molecules.

TL;DR: Endothelial cells could be engineered to express a non-secreted recombinant protein that would inactivate toxic substances circulating in the blood, an approach that extends the concept of immobilized enzymes.

TL;DR: The cellular and biochemical interactions of various natural and synthetic soluble drug carriers are discussed and the possible side effects of these interactions are presented.