Showing papers in "Advanced Drug Delivery Reviews in 2001"

TL;DR: Development of environmentally sensitive hydrogels with a wide array of desirable properties can be made is a formidable challenge, however, if the achievements of the past can be extrapolated into the future, it is highly likely that responsive hydrogelWith such properties can been made.

TL;DR: The utility of polymeric micelles formed through the multimolecular assembly of block copolymers as novel core-shell typed colloidal carriers for drug and gene targeting and their feasibility as non-viral gene vectors is highlighted.

TL;DR: An overview about the selection of the ingredients, different ways of SLN production and SLN applications, and the in vivo fate of the carrier are presented.

TL;DR: The present article is a comprehensive review of the current state of the art of mathematical modeling drug release from HPMC-based delivery systems and discusses the crucial points of the most important theories.

TL;DR: Current research in the stabilization of amorphous solids focuses on the stabilize of labile substances during processing and storage using additives, the prevention of crystallization of the excipients that must remainAmorphous for their intended functions, and the selection of appropriate storage conditions under which amorphously solids are stable.

TL;DR: In this paper, the production of nanoparticles on a laboratory scale is presented, special features such as increased saturation solubility and dissolution velocity are discussed, and special applications are highlighted, for example, mucoadhesive nanosuspensions for oral delivery and surface-modified drug nanoparticles for site-specific delivery to the brain.

TL;DR: Two approaches to further improve the effectiveness of amphiphilic block copolymer-based drug delivery systems are discussed and the feasibility of channel proteins and metal (nano)particles to improve temporal control over the drug release process is discussed.

TL;DR: Intravenously injected doxorubicin-loaded polysorbate 80-coated nanoparticles were able to lead to a 40% cure in rats with intracranially transplanted glioblastomas 101/8, and may be especially helpful for the treatment of the disseminated and very aggressive brain tumors.

TL;DR: This article reviews the approaches which have aimed to associate macromolecules to chitosan in the form of colloidal structures and analyzes the evidence of their efficacy in improving the transport of the associated molecule through mucosae and epithelia.

TL;DR: It was found that PHA producing bacteria are able to grow simultaneously limited by carbon and nitrogen substrates, and it became possible to produce PHA at high yields on toxic substrate and also control its composition accurately (tailor-made synthesis).

TL;DR: The results of the study showed that the nasal chitosan influenza vaccine was both effective and protective according to the CPMP requirements.

TL;DR: Chitosan enhances the functions of inflammatory cells such as polymorphonuclear leukocytes (PMN), phagocytosis, production of osteopontin and leukotriene B4, macrophages, and fibroblasts, which promotes granulation and organization, therefore chitosans is beneficial for the large open wounds of animals.

TL;DR: An introduction into mathematical modeling approaches of bioerodible controlled drug delivery systems and to present the most important erosion theories reported in the literature are given.

TL;DR: Strategies have been developed to protect transfection complexes from non-specific interactions and to increase target specificity and gene expression.

TL;DR: The current research in lymphatic endothelial cell biology and tumor metastasis in the lymphatics is examined because of the increasing potential for targeted delivery of immunomodulators, chemotherapeutics, and genetic material to specific lymph nodes.

TL;DR: Biodegradability, phase behavior, ability to deliver drugs of varying sizes and polarity and the ability to enhance the chemical and/or physical stability of incorporated drugs and proteins make the cubic phase gel an excellent candidate for use as a drug delivery matrix.

TL;DR: Mono-carboxymethylated chitosan (MCC) is a polyampholytic polymer, able to form visco-elastic gels in aqueous environments or with anionic macromolecules at neutral pH values, and appears to be less potent compared to the quaternized derivative.

TL;DR: The application of a gastrointestinal simulation for the prediction of oral drug absorption and bioavailability will be described and the simulated impact of physiological and biochemical processes on oral drug bioavailability is illustrated.

TL;DR: F fluorinated lipids and fluorinated surfactants can be used to elaborate and stabilize various colloidal systems, including different types of emulsions, vesicles and tubules that also show promise for controlled release drug delivery.

TL;DR: This article has conceived of, developed, and tested pre-clinically, a new liposome-based temperature-sensitive drug delivery system for the treatment of solid tumors, and will present the rational design of the newliposome formulation from a materials engineering perspective.

TL;DR: This review examines the advances in the application of chitosan and chitOSan derivatives to non-viral gene delivery, and gives an overview of transfection studies which have been performed recently using ch itosans as transfections agents.

TL;DR: Discovery of the biochemical differences that account for the higher membrane potentials in carcinoma cells is expected to lead to the design of new DLCs targeted specifically to those differences, resulting in even greater selectivity and efficacy for tumor cell killing.

TL;DR: A paradigm of analysis and synthesis has allowed us to obtain a better understanding of physiological barriers in solid tumors, and to develop novel strategies to exploit and/or to overcome these barriers for improved cancer detection and treatment.

TL;DR: In this paper, the preparation and methods for evaluating mucoadhesive nanoparticulate systems, including liposomes and polymeric nanoparticles, including chitosan and Carbopol, were described.

TL;DR: The utility of modified dissolution media to predict the impact of food on the absorption of poorly water soluble, lipophilic drugs, is explored and the use of lipid digestion models which have found increasing application in assessment of the interaction of digestible dose forms with the gastrointestinal milieu are contrasted.

TL;DR: Co-administrations of TMC with peptide drugs were found to substantially increase the bioavailability of the peptide in both rats and juvenile pigs compared with administrations without the polymer.

TL;DR: This review focuses on the various parameters that are considered to be crucial to optimize the use of cationic lipid-DNA complexes for gene therapy purposes, from the biophysical aspects underlying the formation of the complexes to the different biological barriers that need to be surpassed for gene expression to occur.

TL;DR: This overview is a 'snapshot' of the authors' attempts to identify the categories of existing theories needed to encompass all of the relevant events for each possible PIT, to establish a framework of concepts and theories for consideration, discussion, and modeling of PITs.