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Showing papers in "Advanced Drug Delivery Reviews in 2002"


Journal ArticleDOI
TL;DR: The composition and synthesis of hydrogels, the character of their absorbed water, and permeation of solutes within their swollen matrices are reviewed to identify the most important properties relevant to their biomedical applications.

5,173 citations


Journal ArticleDOI
TL;DR: The in vivo fate of these systems, after intravascular or tumoral administration, is discussed, as well as the mechanism involved in tumor regression, and the application of nanoparticles in imaging for cancer diagnosis is focused on.

3,164 citations


Journal ArticleDOI
TL;DR: It is timely to summarize the polymeric systems that undergo sol-gel transitions, particularly due to temperature, with emphasis on the underlying transition mechanisms and potential delivery aspects.

2,048 citations


Journal ArticleDOI
TL;DR: PEG chemistry and methods of preparation are reviewed with a particular focus on new (second-generation) PEG derivatives, reversible conjugation and PEG structures.

1,929 citations


Journal ArticleDOI
TL;DR: As a novel type of lipid nanoparticles with solid matrix, the nanostructured lipid carriers (NLC) are presented and improvements discussed, for example, increase in loading capacity, physical and chemical long-term stability, triggered release and potentially supersaturated topical formulations.

1,783 citations


Journal ArticleDOI
TL;DR: In this overview, different chemical and physical crosslinking methods used for the design of biodegradable hydrogels are summarized and discussed.

1,674 citations


Journal ArticleDOI
TL;DR: The biomolecule-sensitive hydrogels reviewed in this paper are expected to contribute significantly to the exploration and development of newer generations of intelligent biomaterials and self-regulated drug delivery systems.

1,278 citations


Journal ArticleDOI
TL;DR: The focus of this article is to review molecular imprinting within hydrogels and discuss recent efforts on analyte-responsive intelligent gels, specifically suggesting the possibility of utilizing molecular imprinted strategies to impart analyte specificity and responsiveness within these systems.

1,111 citations


Journal ArticleDOI
TL;DR: This review presents a brief mechanistic background of folate-targeted macromolecular therapeutics and then summarizes the successes and failures observed with each major application of the technology.

960 citations


Journal ArticleDOI
TL;DR: The human CYP3A subfamily plays a dominant role in the metabolic elimination of more drugs than any other biotransformation enzyme and may be implicated in disease risk and the metabolism of endogenous steroids or xenobiotics in these tissues.

928 citations


Journal ArticleDOI
TL;DR: This review will introduce the most important cationic polymers used as non-viral vectors for gene and oligonucleotide delivery and will summarize strategies for the targeting of these agents to cancer tissues.

Journal ArticleDOI
TL;DR: Micelle-forming block copolymer-drug conjugates, micellar nanocontainers and polyion complex micelles have been obtained that mimic functional aspects of biological carriers, namely, lipoproteins and viruses that may be advantageous in terms of safety, stability, and scale-up.

Journal ArticleDOI
TL;DR: The synthesis of block copolymers as well as graftCopolymers utilized as DNA delivery systems are described and particular emphasis is devoted to the association behavior and the physicochemical properties of polyion complex micelles entrapping DNA and related substances in relation to the biological aspects of the associates.

Journal ArticleDOI
TL;DR: A new family of nanoscale materials on the basis of dispersed networks of cross-linked ionic and nonionic hydrophilic polymers is being developed, one example is the nanosized cationic network ofcross-linked poly(ethylene oxide) and polyethyleneimine, PEO-cl-PEI nanogel, which has a potential of enhancing oral and brain bioavailability of oligonucleotides.

Journal ArticleDOI
TL;DR: Viable methods now exist for predictions with less than 1 log unit uncertainty, which is adequate for prescreening synthetic candidates or design of combinatorial libraries, which would require an experimental database of highly accurate solubilities for a large, diverse collection of drug-like molecules.

Journal ArticleDOI
TL;DR: Previously reported experience with PEGylated antibodies and antibody fragments are described, and where these types of molecules may find clinical usefulness in the future.

Journal ArticleDOI
TL;DR: Novel applications of Pluronic block copolymers in the treatment of drug-resistant tumors are described as well as mechanistic studies and clinical evaluations of these systems are in progress.

Journal ArticleDOI
Mads Kreilgaard1
TL;DR: In attempt to increase cutaneous drug delivery, microemulsion vehicles have been more and more frequently employed over recent years and a few studies have indicated that the internal structure of microemulsions should allow free diffusion of the drug to optimise cutaneous delivery from these vehicles.

Journal ArticleDOI
TL;DR: Several types of drug delivery systems using hydrogels are discussed that showed pulsed and/or pulsatile drug delivery characteristics and thermal stimuli-regulated pulsed drug release is established through the design of drug Delivery devices, hydrogel, and micelles.

Journal ArticleDOI
TL;DR: In vivo fluorescent videomicroscopy and radiolabel distribution studies of ELP delivery to human tumors implanted in nude mice demonstrated that hyperthermic targeting of the thermally responsive ELP for 1 h provides a approximately two-fold increase in tumor localization compared to the same polypeptide without hyperthermia.

Journal ArticleDOI
TL;DR: Brief analysis of the micellization process and micelle properties shows that micelles made of amphiphilic co-polymers seem to be the most attractive for practical application.

Journal ArticleDOI
TL;DR: Targeted delivery of anticancer agents using poly(L-glutamic acid) as the drug carrier is discussed with emphasis on the design of innovative polymeric constructs.

Journal ArticleDOI
TL;DR: PEG Intron in combination with ribavirin has been shown to be very effective in reducing hepatitis C viral load and maintaining effective sustained viral suppression in patients, and is anticipated to become the new standard of care for the treatment of chronic hepatitis C.

Journal ArticleDOI
TL;DR: Dominant among these attributes is synthesis versatility that allows the facile and reproducible production of polymers having the desired mechanical and thermal properties as well as desired erosion rates and drug release rates that can be varied from a few days to many months.

Journal ArticleDOI
TL;DR: This review focuses on the development, synthesis methods, structures and characterization of polyanhydrides, which will provide an overview for the researchers in the field and discuss their in vitro and in vivo degradability, toxicity, biocompatibility and applications.

Journal ArticleDOI
TL;DR: A number of computational techniques for identifying drug-like molecules are reviewed and challenges facing the field are examined.

Journal ArticleDOI
TL;DR: Novel applications of Pluronic block copolymers in gene therapy are described, which show that these molecules can modify the biological response during gene therapy in the skeletal muscle, resulting in an enhancement of the transgene expression as well as an enhancements of the therapeutic effect of theTransgene.

Journal ArticleDOI
TL;DR: The synthesis and characterization of ABA triblock copolymers from polyester hard segments and poly(ethylene oxide) [PEO] soft segments as well as their biological and degradation properties will be discussed.

Journal ArticleDOI
Olaf B Kinstler1, Graham Molineux1, Michael J. Treuheit1, David Ladd1, Colin V. Gegg1 
TL;DR: A site-directed method of joining proteins to poly(ethylene glycol) is presented which allows for the preparation of essentially homogeneous PEG-protein derivatives with a single PEG chain conjugated to the amine terminus of the protein.

Journal ArticleDOI
TL;DR: The structure-function relationship of the CYP2C9 promoter and coding regions, known polymorphisms, the functional significance of various CYP 2C9 alleles in vitro and in vivo, and their population frequencies are summarized.