Showing papers in "Advanced Drug Delivery Reviews in 2003"

TL;DR: Based on the above mechanism, various potential applications of nanoparticles for delivery of therapeutic agents to the cells and tissue are discussed.

TL;DR: The importance of different collagen types not only for the understanding of collagen-related diseases, but also as a basis for the therapeutical use of members of this protein family discussed in other chapters of this issue is indicated.

TL;DR: The potential utility of multimolecular assembly derived from heterobifunctional PEGs and block copolymers were explored to systematically modify the properties of metal and semiconductor nanostructures by controlling their structure and their surface properties, making them extremely attractive for use in biological and biomedical applications.

TL;DR: This work aims to provide an overview of properties of the mammalian ABC transporters known to mediate significant transport of clinically relevant drugs.

TL;DR: This review focuses on understanding where and how the disulfide bond in the bioconjugate is reduced upon contact with biological milieu, which affects delivery design and the interpretation of the delivery strategies.

TL;DR: General considerations of PEGylation on protein physico-chemical and biological properties could be useful in developing a target product, although significant deviations from the expected results can not be excluded.

TL;DR: An update of drug delivery using poly(ethylene glycol) (PEG), that focuses on recent developments in both protein and organic drugs, is presented, that includes applications of high molecular weight PEG prodrug strategies to amino containing drugs.

TL;DR: Several factors involved in the preparation of adequate matrices, specifically collagen sponges, were investigated in order to test the performance in a new role as an implant providing local delivery of an osteoinductive differentiation factor.

TL;DR: Advances in micro-device technology for proteomics, sample preconditioning, immunoassays, electrospray ionization mass spectrometry, and polymerase chain reaction are reviewed.

TL;DR: An extensive review of the developments and applications of PACAs as nanoparticles for the delivery of drugs is given and considerations concerning the degradation, in vivo distribution, toxicity and cytotoxicity of the nanoparticles are discussed.

TL;DR: Genetic engineering has made great progress in the areas of recombinant collagen and gelatin expression, and there are now several alternatives to bovine material that offer an enhanced safety profile, greater reproducibility and quality, and the ability of these materials to be tailored to enhance product performance.

TL;DR: Collagen gels are flowable, suggesting the possibility of an easily injectable, biocompatible drug delivery matrix, and can act as a "cage" to retain cells or as gene delivery complexes, which are larger than drugs and therapeutic proteins.

TL;DR: This review discusses some of both acellular and cell-containing products used in the treatment of skin wounds, both commercial and experimental, introduced to improve cutaneous wound healing.

TL;DR: Current understanding of the normal solute transport and secretory processes involved in milk production are reviewed, and potential regulatory mechanisms are discussed.

TL;DR: The main clinical and experimental applications covered include: treatment and prophylaxis of bone and soft tissue infections, wound healing, as well as ophthalmic and periodontal treatment.

TL;DR: The drug appears to retain its antileukemic effectiveness while allowing less frequent administration than the native compound, and the reduced need for physician visits and treatment of complications of therapy may make overall treatment costs considerably less than that of the conventional L-asparaginases.

TL;DR: The current review will focus on Pluronic block copolymers in particular, the mechanisms involved in the effects ofpluronic on drug efflux transporters, and the optimal polymer compositions required for inhibition of drug eff Lux transporter activity.

TL;DR: Clinically, it is very difficult to quantitatively differentiate P-gp- mediated drug interactions versus CYP3A4-mediated drug interactions, unless their relative contributions can be accurately estimated, and care should be exercised when interpreting drug interaction data and exploring the underlying mechanisms of drug interactions.

TL;DR: Asymmetrical, drug-loaded microfabricated particles with specific ligands linked to the surface are proposed for improving oral bioavailability of peptide (and perhaps protein) drugs.

TL;DR: Consequences of drug efflux transporters in barriers of the CNS include limiting the distribution of substrates that are beneficial to treat CNS diseases, and increasing the possibility of drug-drug interactions that may lead to untoward toxicities.

TL;DR: This review focuses on one particular structure synthesized by extending oligomeric lactide prepolymers with ethylphosphate groups, which is promising in delivering anti-cancer therapeutics in the form of microspheres.

TL;DR: Collagens are not only major constituents of connective tissues in terms of integrity and function, they are also major targets of tissue destruction and regeneration and might become major tools to achieve tissue repair.

TL;DR: A short introduction to the basic findings on PNA as an antisense and antigene agent in cell-free in vitro systems and a comprehensive evaluation of the most interesting literature concerning cellular delivery and the intracellular effect of PNA are given.

TL;DR: Here, tyrosine-derived polycarbonates, polyarylates, and polyethers are reviewed with special emphasis on recent developments relating to cellular and in vivo responses, sterilization techniques, surface characterization, drug delivery, and processing and fabrication techniques.

TL;DR: Biodegradable polyphosphazenes, due to their hydrolytic instability, nontoxic degradation products, ease of fabrication and matrix permeability, are an excellent platform for controlled drug delivery applications.

TL;DR: Together with drug metabolising enzymes, transmembrane transporters are important determinants of drug metabolism and drug clearance by the liver and are subject to genetic polymorphism in the encoding genes as well as in these transcription factors.

TL;DR: Current data concerning the growth and maturation of the physiological and biochemical factors governing absorption, distribution, metabolism, and excretion are reviewed and some insight is provided into how these developmental changes alter the efficiency of pharmacokinetics in the infant.

TL;DR: Some of the most widely used or promising new models for chronic pain, including partial spinal ligation, chronic constriction injury, and L5/L6 spinal nerve ligation are reviewed.

TL;DR: This review deals with the preparation of polymers from dicarboxylic acid monomers, and the result in terms of properties and applicability, of particular interest is the inherent biodegradability of the ester linkage.

TL;DR: The literature describing neural network modelling to predict physicochemical properties of organic compounds from the molecular structure is reviewed from the perspective of pharmaceutical research, and the standard three-layer, feed-forward neural network is the technique most frequently used.