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Showing papers in "Advanced Drug Delivery Reviews in 2005"


Journal ArticleDOI
TL;DR: The reflections on biomedical applications of dendrimers given in this review clearly demonstrate the potential of this new fourth major class of polymer architecture and indeed substantiate the high hopes for the future of dendedrimers.

1,828 citations


Journal ArticleDOI
TL;DR: Preclinical and clinical experience gained during the development of polymeric excipients, biomedical polymers and polymer therapeutics shows that judicious development of dendrimer chemistry for each specific application will ensure development of safe and important materials for biomedical and pharmaceutical use.

1,083 citations


Journal ArticleDOI
TL;DR: New mucoadhesive materials with optimal adhesive properties are now being developed, and these should enhance the potential applications of this technology.

951 citations


Journal ArticleDOI
TL;DR: A review of the role of dendrimers in those aspects of synthetic vector development is presented in this article, where the authors focus on the current understanding of the current role of Dendrimer-based transfection agents.

903 citations


Journal ArticleDOI
TL;DR: In the present update on mucoadhesive ocular dosage forms, the tremendous advances in the biochemistry of mucins, the development of new polymers, the use of drug complexes and other technological advances are discussed.

844 citations


Journal ArticleDOI
TL;DR: Cell-penetrating peptides are short peptides of less than 30 amino acids that are able to penetrate cell membranes and translocate different cargoes into cells, whose properties make them potential drug delivery agents, of interest for future use.

798 citations


Journal ArticleDOI
TL;DR: This review focuses on recent pharmaceutical NIR applications and covers basic principles of NIR techniques including chemometric data processing, regulatory issues, raw material identification and qualification, direct analysis of intact solid dosage forms, and process monitoring and process control.

776 citations


Journal ArticleDOI
TL;DR: This review will present the current status of knowledge of these aspects of antibiotic resistance and discuss how a thorough understanding of resistance enzyme molecular mechanism, three-dimensional structure, and evolution can be leveraged in combating resistance.

757 citations


Journal ArticleDOI
TL;DR: The delivery of different molecules and particles mediated by TAT, Antp, VP22, and other CPPs are reviewed as well as potential applications of these delivery systems in different areas of vaccine development, cancer immunotherapy, gene delivery, and cellular imaging.

662 citations


Journal ArticleDOI
TL;DR: A review of the oral mucosa, mechanism of drug permeation, and characteristics of the desired polymers, followed by the recent mucoadhesive formulations for buccal drug delivery.

646 citations


Journal ArticleDOI
TL;DR: The mechanism by which the Tat peptide adheres to, and crosses, the plasma membrane of cells is currently a topic of heated discussion in the literature, with varied findings being reported.

Journal ArticleDOI
TL;DR: This study demonstrates that while drug as a dendrimer inclusion complex is readily released and active in vitro, covalently conjugated drug to d endocytosis is better suited for specifically targeted drug delivery.

Journal ArticleDOI
TL;DR: The application of dendrimer-drug complexation in the enhancement of drug solubility and bioavailability and the use of the complexes as vehicles for the controlled release of drugs and drug targeting is discussed.

Journal ArticleDOI
TL;DR: The higher efficacy of this new generation of mucoadhesive polymers in comparison to the corresponding unmodified muco adhesion basis polymers could be verified via various in vivo studies on various mucosal membranes in different animal species and in humans.

Journal ArticleDOI
TL;DR: New classes of functionalized mucoadhesive polymers, the characterization and safety aspects of nasal drug products as well as the opportunities presented by nasal drug delivery are extensively discussed.

Journal ArticleDOI
TL;DR: This review examines several impediments to PLGA microparticle development, such as PLGA-encapsulated antigen instability and deficiency of animal models in predicting human response, and describes new trends in overcoming these important issues.

Journal ArticleDOI
TL;DR: This novel technique for protein and peptide delivery appears to circumvent many problems associated with DNA and drug based methods and may represent the next paradigm in the ability to modulate cell function and offers a unique avenue for the treatment of disease.

Journal ArticleDOI
TL;DR: A review of the current knowledge of permeability barriers for and active efflux of drug molecules and potential strategies to overcome them suggests these mechanisms may be good targets for new drugs.

Journal ArticleDOI
TL;DR: A number of elements in the process of biofilm formation have been studied as targets for novel drug delivery technologies, including surface modification of devices to reduce bacterial attachment and biofilm development as well as incorporation of antimicrobials-again to prevent colonisation.

Journal ArticleDOI
TL;DR: Gadolinium-based MRI contrast agents (CAs) can be effective at a approximately 100-fold lower concentration of Gadolinium ions in comparison to the concentration of Iodine atoms required for CT imaging as discussed by the authors.

Journal ArticleDOI
Shiroh Futaki1
TL;DR: It is shown that not only the Tat peptide, but also various arginine-rich oligopeptides possess very similar characteristics in translocation and abilities as a delivery vector, and the current understanding of their internalization mechanisms.

Journal ArticleDOI
TL;DR: The pH of polymer and drying method were found to be important factors influencing the mucoadhesive potential of polymers and the rank order obtained for adhesion time was in agreement with the rankOrder obtained for total work of adhesion.

Journal ArticleDOI
TL;DR: The basic principles behind various physical methods for gene transfer are described and the advantages and performance of such approaches, compared to other transfection systems, are assessed.

Journal ArticleDOI
TL;DR: The structure of occludin, including its gene splice variants and protein essential components have been elucidated and phosphorylation/dephosphorylation plays a major role in regulation of occLudin and TJ.

Journal ArticleDOI
TL;DR: The first section of this article discusses enantioselective optimization of polymerization, the second section will review methods employed for evaluation of MIPs and the last section will cover materials science methods used to characterize the physical properties of M IP materials.

Journal ArticleDOI
TL;DR: The constraints and challenges of drug delivery to the posterior segment are investigated, and several potential absorption pathways that may potentially be exploited to deliver drug to the back of the eye are outlined.

Journal ArticleDOI
TL;DR: In this review the main synthetic strategies used in the preparation of imprinted organic polymers are described in terms of the chemical principlesused in the templating step and are classified as covalent, semi-covalents, non-cavalent, metal-mediated and non-polar.

Journal ArticleDOI
TL;DR: A better understanding of the cellular and molecular basis of non-viral vector trafficking from the extracellular compartment into the nucleus may provide strategies to overcome those obstacles that limit the efficiency of gene delivery.

Journal ArticleDOI
TL;DR: This review highlights the most important studies based on mucoadhesive polymer-systems like poly(acrylates), chitosan, cellulose derivatives, hyaluronic acid derivatives, pectin and traganth, starch, poly(ethylene glycol), sulfated polysaccharides, carrageenan, Na-alginate and gelatine.

Journal ArticleDOI
TL;DR: This review provides an applicable summary of different formulation routes for the purpose of producing safe, qualified and efficacious products of microencapsulated peptide and protein antigens.