Showing papers in "Advanced Drug Delivery Reviews in 2006"

TL;DR: The majority of examples, discussed in this paper, deal with pH-responsive drug delivery system, and Thermo-responsive polymer is also covered to a large extent, as well as double-responsive system.

TL;DR: The objective of this article is to review the fundamentals and recent advances in hydrogel network design as well as mathematical modeling approaches related to controlled molecule release from hydrogels.

TL;DR: Stem cell migration and immune cell trafficking, as well as targeted iron oxide nanoparticles for molecular imaging studies, are at the stage of proof of concept, mainly in animal models.

TL;DR: The most important parameters that influence the success of freeze-drying of these fragile systems are discussed, and an overview of nanoparticles freeze-Drying process and formulation strategies are provided with a focus on the impact of formulation and process on particle stability.

TL;DR: This review explores the recent development of polymeric gene carriers and presents the future directions for the application of the polymer-based gene delivery systems in gene therapy.

TL;DR: This review presents an overview of the essential factors in ocular pharmacokinetics and selected pharmacological future challenges in ophthalmology.

TL;DR: This review brings together all the toxicological and pharmacological in vivo studies that have been carried out using carbon nanotubes, to offer the first summary of the state-of-the-art in the pharmaceutical development of carbon Nanotubes on the road to becoming viable and effective nanomedicines.

TL;DR: The early impact of nanotechnology on medicine is beginning to get realized, with novel nanoscale therapeutic and diagnostic modalities under development or in clinical practice today.

TL;DR: Past and present research on various applications of natural polymers as particulate and matrix delivery vehicles for gene delivery and tissue engineering scaffolding applications are highlighted.

TL;DR: This article aims to provide a comprehensive review of existing mathematical models and simulations of drug release from polymeric microspheres and of drug transport in adjacent tissues and to evaluate the application of existing models to nanoscale drug delivery systems specifically for hydrophobic and hydrophilic molecules.

TL;DR: Technical challenges in the formulation of antibody-based materials to maintain sufficient stability in a variety of configurations and sometimes at particularly high concentrations are reviewed.

TL;DR: There is a clear and immediate need for understanding of the mechanisms which cause polyfectin toxicity which will ultimately facilitate improved vector design and safer gene delivery and strategies for reduction of toxicity are included.

TL;DR: The rationale for delivery of needle-free vaccines is summarized and several methods currently in use and under development, focusing on needle- free injection devices, transcutaneous immunization, and mucosal immunization are discussed.

TL;DR: The development of novel drugs in combination with new formulations for IA treatment of OA, represents a promising approach in this challenging area of research.

TL;DR: Creative science has lead to a number of ways to counter the immunogenicity of non-human antibodies, primarily through chimeric, humanized, de-immunized, and most recently, human-sequence therapeutic antibodies.

TL;DR: The transient opening of the TJs by Zot suggests that it could be used as a novel approach for the safe drug delivery of therapeutic agents.

TL;DR: The clinical importance of drug-eluting stents has been demonstrated by their unparalleled success in preventing restenosis after stenting procedures, and it is imperative to understand the drug delivery mechanisms and the approaches available for drug coating on the stents.

TL;DR: The transporters probably have greater role in ocular pharmacokinetics than the authors currently realise according to the current knowledge about the corneal epithelium and blood-retina barrier.

TL;DR: In vivo, in vitro and ex vivo models currently available for studying lung absorption and disposition for inhaled therapeutic molecules, as well as the intermediate ex vivo model of the isolated perfused lung (IPL) appears to resolve deficiencies of these in vivo and in vitro models.

TL;DR: Recent advances in nanoparticle-based detection and therapy of brain cancer are described and the types of nanoparticle systems under investigation are described, as well as their applications.

TL;DR: This paper reviews the presently developed techniques for particle engineering biopharmaceuticals and concludes that some of these techniques are quite promising, some are harsh and impracticable.

TL;DR: The scope of this review is the recent advancements in the display technologies with a particular emphasis on molecular mapping of cell surface proteomes with peptide phage display and prospects of targeted compounds derived from display libraries in the discovery of targeted drugs and gene therapy vectors are discussed.

TL;DR: VNPs are focused on virus-based nanoparticles as platforms for the development of tissue-specific targeting and imaging agents in vivo to facilitate early detection and reduce adverse side effects of treatment.

TL;DR: Basic biology mechanisms for cartilage reconstruction are explored, the limits of the new methods and their potential application in the osteoarthritic conditions are discussed, and the advances in the tissue engineering approaches are summarized.

TL;DR: Some of the latest technologies for the design, mutation and selection of high affinity antibodies that provide a paradigm for molecular evolution of a far wider range of proteins including enzymes are described.

TL;DR: An overview of ocular implants with therapeutic application potentials is provided andMiniaturization of the implants allowing for their direct injection without the need for a complicated surgery is a necessary development avenue.

TL;DR: The aim of this article is to review the basic principles of two-photon excitation fluorescence (2PEF) microscopy and to compare the advantages and disadvantages of 2PEF imaging to other microscopy methodologies.

TL;DR: The encapsulation of DNA into polymeric depot systems can be used to spatially and temporally control DNA release, leading to a sustained, local delivery of therapeutic factors for tissue regeneration, indicating the broad applicability of these systems for tissue engineering.

TL;DR: Retrovirus, adenov virus, adeno-associated virus and herpes virus are widely studied viral gene transfer systems and have attracted the most attention in the field of transduction.

TL;DR: These innovative multiphoton technologies have been used to probe architecture and state of a variety of native tissues, as well as of tissue-engineered constructs, giving insights on the interaction between scaffolds and seeded cells in vitro prior implantation.