Showing papers in "Advanced Drug Delivery Reviews in 2008"

TL;DR: Gold nanoparticles provide non-toxic carriers for drug and gene delivery applications and their interaction with thiols is an effective and selective means of controlled intracellular release.

TL;DR: This review highlights the recent research developments of a series of surface-functionalized mesoporous silica nanoparticle (MSN) materials as efficient drug delivery carriers and envision that these MSN-based systems have a great potential for a variety of drug delivery applications.

TL;DR: A background on applications of MNPs as MR imaging contrast agents and as carriers for drug delivery and an overview of the recent developments in this area of research are provided.

TL;DR: Hydrogel nanoparticles have gained considerable attention in recent years as one of the most promising nanoparticulate drug delivery systems owing to their unique potentials via combining the characteristics of a hydrogel system with a nanoparticle, each with its own advantages and drawbacks.

TL;DR: The targeting schemes explored for many of the reported nanoparticle systems suggest the great potential of targeted delivery to revolutionize cancer treatment.

TL;DR: In this review, four mechanisms are introduced to prepare polysaccharides-based nanoparticles, that is, covalent crosslinking, ionic crossl linking, polyelectrolyte complex, and the self-assembly of hydrophobically modified poly Saccharides.

TL;DR: Current biomimetic materials approaches in tissue engineering include synthesis to achieve certain compositions or properties similar to those of the extracellular matrix, novel processing technologies to achieve structural features mimicking the ext racellular matrix on various levels, and biologic delivery strategies to recapitulate a signaling cascade or developmental/wound healing program.

TL;DR: The synthesis and development of state-of-the-art QD probes and their use for molecular and cellular imaging are discussed and key issues for in vivo imaging and therapy, such as nanoparticle biodistribution, pharmacokinetics, and toxicology are examined.

TL;DR: A functional classification for nanoparticles in PDT is introduced to divide them into passive carriers and active participants in photosensitizer excitation, and these active or second-generation PDT nanoparticles probably offer the best hope for extending the reach of PDT to regions deep in the body.

TL;DR: DNA delivery and successful tissue transfection are observed in the areas of the body where ultrasound is applied after intravascular administration of microbubbles and plasmid DNA.

TL;DR: A review of the recent biomedical applications of these newer magnetic nanomaterials targeted to specific cell types and molecular targets via affinity ligands.

TL;DR: The novel biological properties and applications of three most widely used metal nanoparticles, namely, the nanoparticles of gold, silver and platinum are discussed.

TL;DR: The optical properties of photonic structures prepared from porous Si or SiO2 hosts provide a self-reporting feature that can be monitored in vivo.

TL;DR: The properties of excipients are discussed, the formulation strategies that can be used for each type of lipid formulation are outlined, and a framework for the in vitro testing of each type is suggested.

TL;DR: The goal of investigators working on cartilage regeneration is to develop a system that promotes the production of cartilage tissue that mimics native tissue properties, accelerates restoration of tissue function, and is clinically translatable.

TL;DR: New cationic polyrotaxanes composed of multiple oligoethylenimine-grafted CDs threaded and end-capped on a block copolymer chain were designed and synthesized as a new class of polymeric gene delivery vectors, where the chain-interlocked cationIC cyclic units formed an integrated supramolecular entity to function as a macromolecular gene vector.

TL;DR: Preliminary data suggest roles for nab-paclitaxel as a single agent and in combination therapy for first-line treatment of metastatic breast cancer as well as in other solid tumors, including non-small-cell lung cancer, ovarian cancer, and malignant melanoma.

TL;DR: The mechanistic rationale which underpins the use of lipid-based delivery systems to enhance drug solubilisation is described and the available literature describing increases in oral bioavailability after the administration of lipid solution, suspension and self-emulsifying formulations is reviewed.

TL;DR: Current knowledge on TLR3 is summarized and its possible role in innate and adaptive immunity is discussed and involved in activation of NK cells and CTLs by myeloid DCs suggests thatTLR3 serves as an inducer of cellular immunity sensing viral infection rather than a simple IFN inducer.

TL;DR: The concept of using quantum dots and nanoparticles to yield electrons and radicals in photodynamic and radiation therapies as well their combination is reviewed in this article.

TL;DR: A summary of theoretical and experimental approaches to analyze and improve antibody penetration in tumor tissue and how to select for more resistant cells is presented.

TL;DR: The advantages and versatility of CuAAC in scientific disciplines as diverse as drug discovery, biochemistry, bioconjugates synthesis, drug-delivery, gene therapy, bioseparation or diagnostics are presented and discussed in detail.

TL;DR: The focus of this review is on dendrimer developments from the last four years for oncological applications, with emphasis on distinct architectures and the biological responses these structures elicit.

TL;DR: The intriguing hypothesis that the attenuation of the oxidative stress induced by the inactivation of either MAO isoform may contribute to both antidepressant and antiparkinsonian actions of MAO inhibitors is discussed.

TL;DR: Clinical trial results for various vaccine adjuvants and delivery vehicles being developed that are approximately nanoscale (<1000 nm) in size are discussed.

TL;DR: The first sections of this review aim at reporting on the evolution of the initiators/catalytic systems and of the synthesis conditions in order to produce aliphatic polyesters with controlled macromolecular parameters by still "greener" ways.

TL;DR: The manner by which acoustic energy deposition can be used to create changes in tissue permeability for enhancing the delivery of conventional agents, as well as for deploying and activating drugs and genes via specially tailored vehicles and formulations is reviewed.

TL;DR: The basic physics of ultrasound generation, acoustic field, and both inertial and non-inertial acoustic cavitation in the context of localized gene and drug delivery as well as non-linear oscillation of an encapsulated microbubble and its associated microstreaming and radiation force generated by ultrasound are reviewed.

TL;DR: Applications of natural and synthetic materials, their modifications as well as various culture conditions for maintenance and lineage-specific differentiation of embryonic and adult stem cells are examined.

TL;DR: New technologies that combine the use of nanoparticles with acoustic power both in drug and gene delivery both in vitro and in vivo are summarized.