Showing papers in "Advanced Drug Delivery Reviews in 2009"

TL;DR: The tenacious mucus barrier properties that have precluded the efficient penetration of therapeutic particles are described and the design and development of new mucus-penetrating particles that may avoid rapid mucus clearance mechanisms are reviewed to provide targeted or sustained drug delivery for localized therapies in mucosal tissues.

TL;DR: Recent research on nanoparticle physicochemical properties important for protein binding, techniques for isolation and identification of nanoparticle-bound proteins, and how these proteins can influence particle biodistribution and biocompatibility are reviewed.

TL;DR: The physiological and biochemical properties that form the mucus barrier are reviewed, including shear-thinning, which makes it an excellent lubricant that ensures an unstirred layer of mucus remains adherent to the epithelial surface.

TL;DR: The biochemistry that governs mucus rheology, the macro- and microrheology of human and laboratory animal mucus, rheological techniques applied to mucus are reviewed, and the importance of an improved understanding of the physical properties of mucus to advancing the field of drug and gene delivery is reviewed.

TL;DR: Surfaces of electrospun polymeric nanofibers were chemically functionalized for achieving sustained delivery through physical adsorption of diverse bioactive molecules for controlled drug delivery and tissue engineering.

TL;DR: The role of MNP size, composition and surface chemistry in their intracellular uptake, biodistribution, macrophage recognition and cytotoxicity, and review current studies on MNP toxicity, caveats of nanotoxicity assessments and engineering strategies to optimize MNPs for biomedical use are discussed.

TL;DR: The physicochemical properties of four representative nanomaterials (dendrimers, carbon nanotubes, quantum dots, and gold nanoparticles) as it relates to their toxicity after systemic exposure is discussed.

TL;DR: Various in vivo delivery strategies including chemical modification, conjugation, lipid-based techniques, polymer-based nanosystems, and physical methods, and the current progress in siRNA delivery systems for gynecologic, liver, lung, and prostate cancers is discussed.

TL;DR: Clinical relevant performance of the polymeric micelles provides a promising approach for more efficient and patient-friendly cancer therapy and potentiate combination delivery of multiple drugs using mixed micells.

TL;DR: This review will compare siRNA, shRNA and bi-functional shRNA, finding that optimized shRNA constructs allow for high potency and sustainable effects using low copy numbers resulting in less off-target effects, particularly if embedded in a miRNA scaffold.

TL;DR: Early studies of polymer-drug conjugates for multi-agent therapy revealed the therapeutic potential but raised new challenges that need to be addressed for a successful optimisation of the system towards clinical applications.

TL;DR: This review describes recent advances in the use of CPPs for biological and therapeutic applications and describes the remarkable advancements these peptides have facilitated in cell biology.

TL;DR: Improved physicochemical nanomaterial assays are needed to provide accurate exposure risk assessments and genuine predictions of in vivo behavior and therapeutic value, particularly in realistic physiological or environmental models containing cells, proteins and solutes.

TL;DR: Preclinical and early clinical data support the use of TLR9 agonists as vaccine adjuvants, where they can enhance both the humoral and cellular responses to diverse antigens, and safety and efficacy in humans remain to be determined.

TL;DR: The characteristics of various polysaccharides such as alginate, cellulose, chitin,chitosan, hyaluronic acid, starch, dextran, and heparin, which are either currently being used or have potential to be used for electrospinning are summarized.

TL;DR: The state-of-the-art of using electrohydrodynamic technique to generate nanofiber/particles as drug delivery devices to enhance the material's functionality in tissue engineering applications is discussed.

TL;DR: With the improvement in knowledge and techniques of bone-targeted nanofibrous matrices, bone tissue engineering is expected to be realized in the near future.

TL;DR: A unique therapeutic strategy was developed named "oxidation therapy", by delivering cytotoxic ROS directly to the solid tumor, or alternatively inhibiting the antioxidative enzyme system, such as HO-1 in tumor, to achieve the objective of tumor targeting and thus reducing side effects.

TL;DR: Although an Hsp based therapy appears to be a promising approach for the treatment of diseases that involve oxidative damage, there are some significant hurdles that must be overcome before this approach can be successful.

TL;DR: PEGylation proved to be effective in shielding sensitive sites at the protein surface, such as antigenic epitopes and enzymatic degradable sequences, as well as in prolonging the drug half-life by decreasing the kidney clearance.

TL;DR: This review discusses the challenges in systemic siRNA delivery by dividing them into two categories-kinetic and physical barriers and different strategies to overcome these barriers, especially focusing on the step of endosome escape.

TL;DR: This review will highlight some of the work done in the field of electrospinning for cardiovascular applications, with an emphasis on the use ofBiopolymers such as collagens, elastin, gelatin, fibrinogen, and silk fibroin, as well as biopolymers used in combination with resorbable synthetic polymers.

TL;DR: Research into the transporter's role in cancer drug resistance and its development as a therapeutic target in cancer has lagged but emerging studies in pharmacology and toxicology assessing polymorphic variants in man, in combination with murine knockout models have confirmed its dynamic role.

TL;DR: A review of the latest applications of carbon nanofibers and carbon nanotubes in regenerative medicine can be found in this article, where the authors focus on the application of carbon carbon nanostructures in the field of bio-inspired medicine.

TL;DR: This review covers research related to electrospinning of silk, including process parameters, post treatment of the spun fibers, functionalization of nanofibers, and the potential applications for these material systems in regenerative medicine.

TL;DR: Sub-micron and nano-scale fibrous scaffolds which mimic the topography of natural extracellular matrix (ECM) can be potential scaffold candidates for neural tissue engineering.

TL;DR: This paper is the first review of its kind and offers greater insight into squalene's direct or indirect contribution to disease management and therapy.

TL;DR: The feasibility of using Electrospun fibrous scaffolds to present integrated topographical and biochemical signals that are essential to stem cell manipulation has been demonstrated and future application of this versatile scaffold platform to human embryonic and induced pluripotent stem cells for functional tissue repair and regeneration will further expand its potential for regenerative therapies.

TL;DR: Preclinical and clinical observations made in HPMA copolymer-based conjugate, and clinical studies with other polymer conjugates, should shape the development of next generation anticancer polymer therapeutics.

TL;DR: The need for evolution of an appropriate regulatory framework is at the forefront of the scientific discussion because of the increasing novelty of polymeric materials proposed for development as second-generation polymer therapeutics (with increasing complexity of conjugate composition).