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Showing papers in "Advanced Drug Delivery Reviews in 2010"


Journal ArticleDOI
TL;DR: The newest developments in chitosan hydrogel preparation are investigated and the design parameters in the development of physically and chemically cross-linked hydrogels are defined.

2,034 citations


Journal ArticleDOI
TL;DR: The design parameters that affect MNP performance in vivo are summarized, including the physicochemical properties and nanoparticle surface modifications, such as MNP coating and targeting ligand functionalizations that can enhance MNP management of biological barriers.

1,659 citations


Journal ArticleDOI
TL;DR: Research in this area is reviewed and chitosan's potential to be used as a generally regarded as safe (GRAS) material is critically discussed.

1,432 citations


Journal ArticleDOI
TL;DR: The current article will outline the progress along this line, organized by the category of the core materials, and focus on construction strategies and will discuss the challenges and opportunities associated with this emerging technology.

1,229 citations


Journal ArticleDOI
TL;DR: State-of-the-art nanoparticles from a therapeutic and a diagnostic perspective are reviewed and challenges in bringing these fields together are discussed and potential advantages that will spur the development of theranostic agents are discussed.

1,066 citations


Journal ArticleDOI
TL;DR: Chitosan structure modification or additive incorporation is an effective way to improve the stability of the polyplex in biological fluids, enhance targeted cell delivery and facilitate endo-lysosomal release of the complex.

866 citations


Journal ArticleDOI
TL;DR: The main objective of this review is to provide an insight into various target-specific carriers, based on chitosan and its derivatives, towards low molecular weight drug delivery.

739 citations


Journal ArticleDOI
TL;DR: This review summarizes some of the recent developments in the field of nanomedicine with particular emphasis on inorganic nanoparticles for drug delivery, and lessons learned from the toxicological investigation of three common types of engineered nanomaterials of titania, gold, and mesoporous silica are discussed.

637 citations


Journal ArticleDOI
TL;DR: This review provides an overview of chitosan-based polymers for preparation of both therapeutic peptides/protein and antigen formulations and their applications in protein and antigen delivery through parenteral and mucosal administrations.

547 citations


Journal ArticleDOI
TL;DR: The overview covers the discovery of N-(2-hydroxypropyl)methacrylamide (HPMA) copolymers, initial studies on their synthesis, evaluation of biological properties, and explorations of their potential as carriers of biologically active compounds in general and anticancer drugs in particular.

514 citations


Journal ArticleDOI
TL;DR: The emerging roles of nanoparticles, especially gold, in the hyperthermic treatment of cancer and the similarities of radiofrequency ablation and nanoparticle mediated cytotoxicity are discussed.

Journal ArticleDOI
TL;DR: Recent developments in the use of light-triggered theranostic agents for simultaneous imaging and photoactivation of therapeutic agents for several diseases are reviewed.

Journal ArticleDOI
TL;DR: How the unique physico-chemical properties of gold nanoparticles may be utilized for targeted drug delivery in pancreatic cancer leading to increased efficacy of traditional chemotherapeutics is discussed.

Journal ArticleDOI
TL;DR: This paper reviews recent advances in nano/microfluidic technologies for clinical point-of-care applications at resource-limited settings in developing countries and potentially applicable to global health applications.

Journal ArticleDOI
TL;DR: Recent advances in the understanding of PXR and CAR as xenosensors are discussed with emphasis placed on the differences rather than similarities of these two xenobiotic receptors in ligand recognition and target gene regulation.

Journal ArticleDOI
TL;DR: The utility of silk-based multi-block copolymer systems and related silk protein drug delivery systems for the delivery of small molecule drugs, proteins and genes is reviewed.

Journal ArticleDOI
TL;DR: The technical advances together with the ever increasing knowledge and experience in the field will undoubtedly lead to the realization of the full potential of cell encapsulation in the future.

Journal ArticleDOI
TL;DR: The results collected up until now suggest the potential of the delivery platform based on the polysaccharide chitosan and the subsequent need of a full preclinical evaluation in order to satisfy the specific regulatory demands of this mode of administration.

Journal ArticleDOI
TL;DR: This review summarizes the current understanding of how retinoids are processed and act with an emphasis on the application of retinoid in cancer treatment and prevention.

Journal ArticleDOI
TL;DR: A basic overview of ELP properties and modifications that are relevant to tissue engineering are presented, as well as a discussion of the application of ELPs to cartilage, intervertebral disc, vascular graft, liver, ocular, and cell sheet engineering.

Journal ArticleDOI
TL;DR: This review surveys some of the emerging approaches in the field of nanoparticle based detection systems, highlighting the nanoparticles based screening methods for metal ions, proteins, nucleic acids, and biologically relevant small molecules.

Journal ArticleDOI
TL;DR: Different RNA-based approaches for diagnosis, prevention and treatment of human disease are covered, with a focus on the latest developments of non-viral carriers of siRNA for delivery in vivo.

Journal ArticleDOI
TL;DR: Methods of integrating aptamers specific for a wide range of targets are first introduced and compared to antibodies, and applications of these systems as fluorescent, colorimetric, magnetic resonance imaging, and electrochemical sensors in medical diagnostics are given, along with new applications as smart drug delivery agents.

Journal ArticleDOI
TL;DR: Nanoporous inorganic coatings are well suited to provide improved efficacy and integration of implants in a variety of therapeutic situations and can be used effectively for sustained release applications.

Journal ArticleDOI
TL;DR: The present review thoroughly overviews the state-of-the-art in the development of nano-based drug delivery systems for encapsulation and release of anti-TB drugs and discusses the challenges that are faced in theDevelopment of a more effective, compliant and also affordable TB pharmacotherapy.

Journal ArticleDOI
TL;DR: The various nanodiagnostic assays developed to image, detect and capture infectious virus and bacteria in solutions, food or biological samples in vitro and in vivo are presented and their relevance to developing countries is discussed.

Journal ArticleDOI
TL;DR: The main requirements for developing new nanotechnology-based carriers as a promising choice in malaria treatment, especially in the case of severe cerebral malaria are emphasized, taking into account the peculiarities of malaria parasites.

Journal ArticleDOI
TL;DR: Promising results hint to the adoption of nanotechnology-based diagnostics for the diagnosis of infectious diseases in diverse settings throughout the globe, preventing epidemics and safeguarding human and economic wellness.

Journal ArticleDOI
TL;DR: An overview of the most common chemical approaches for the synthesis of PET-labeled molecules is provided and the most recent developments and trends are highlighted.

Journal ArticleDOI
TL;DR: The present review will discuss the strengths, limitations and challenges of molecular Imaging as well as applications of chitosan nanoparticles in the field of molecular imaging.