Showing papers in "Advanced Drug Delivery Reviews in 2011"

TL;DR: Molecular mechanisms of factors related to the EPR effect, the unique anatomy of tumor vessels, limitations and techniques to avoid such limitations, augmenting tumor drug delivery, and experimental and clinical findings are discussed.

TL;DR: The role of the EPR effect in the intratumoral delivery of protein and peptide drugs, macromolecular drugs and drug-loaded long-circulating pharmaceutical nanocarriers is briefly discussed together with some additional opportunities for drug delivery arising from the initial EPReffect-mediated accumulation of drug-containing macromolescular systems in tumors.

TL;DR: This review covers recent advances in the development of SPions together with their possibilities and limitations from fabrication to application in drug delivery and the state-of-the-art synthetic routes and surface modification of desired SPIONs for drug delivery purposes.

TL;DR: Potential opportunities for the combination of hyperthermia-based therapy and controlled drug release paradigms--towards successful application in personalized medicine are portrayed.

TL;DR: Prevascularization techniques are compared to approaches in which biomolecules, such as growth factors, cytokines, peptides and proteins as well as cells are applied to generate new vessels to create vascularized tissues in vitro.

TL;DR: Drug-loaded nanoparticles extravasate through the tumour vasculature, delivering their payload into the cells by the enhanced permeability and retention (EPR) effect, thereby increasing their therapeutic effect.

TL;DR: The physical and chemical stability of drug nanoparticles, including their mechanisms and corresponding characterization techniques are reviewed, and a few common strategies to overcome stability issues are discussed.

TL;DR: Unpublished clinical data on nanoparticle penetration and previously published reports support the hypothesis that nanoparticles >10nm in diameter are unlikely to penetrate through the stratum corneum into viable human skin but will accumulate in the hair follicle openings, especially after massage.

TL;DR: This review describes mechanisms and basic principles of stimuli effects, describes progress in the area, and gives an outlook on emerging trends such as theranostics and nanomedicine.

TL;DR: Small molecular inhibitors for FAK kinase activity as well as future development of novel therapies targeting the potentially kinase-independent functions of FAK are promising treatments for metastatic cancer aswell as other diseases.

TL;DR: The development and applications of MEND are described, and strategies for overcoming the PEG dilemma are discussed, based on the manipulation of intracellular trafficking of cellular uptake and endosomal release using functional devices such as specific ligands, cleavable PEG systems andendosomal fusogenic/disruptic peptides.

TL;DR: In this paper, a review summarizes the advances in in vivo and in vitro applications of tissue-engineered skin and highlights novel efforts in the design of complex disease-in-a-dish models for studies ranging from disease etiology to drug development.

TL;DR: Transferrin-PEG-liposomes improve the safety and efficacy of anti cancer drug by both passive targeting by prolonged circulation and active targeting by transferrin.

TL;DR: Suitable formulations for the most commonly used routes of administration can be identified with milligram quantities of drug substance providing the discovery scientist an alternate avenue for screening and identifying superior leads.

TL;DR: Key mechanisms of protein-excipient interactions such as electrostatic and cation-pi interactions, preferential hydration, dispersive forces, and hydrogen bonding are presented in the context of different physical states of the formulation.

TL;DR: Different approaches to fabricate polymeric nanostructures of various shapes are reviewed, a comprehensive summary on the current understandings of the influence of nanostructure with different shapes on important biological processes in drug delivery is provided, and future perspectives for the development of nanstructures with well-defined shapes for drug delivery are discussed.

TL;DR: Recent developments in photoresponsive hydrogels are reviewed and these new materials are discussed, and their applications in the biomedical field are discussed.

TL;DR: This review focuses on preparation of layer-by-layer shells directed at drug delivery applications and recent progress in the field of self-assembled microshells and nanoshells for drug deliveryApplications is summarized.

TL;DR: This review focuses on bottom-up processes such as precipitation and single droplet evaporation to produce nanoparticles containing largely pure therapeutics for pharmaceutical applications, and a key to the success of yielding stable nanoparticles in these various techniques is to control the particle growth kinetics throughEvaporation rate of the droplets or mixing rate during precipitation.

TL;DR: The review evaluates the use of in vitro C assays and the porcine liposome-induced cardiopulmonary distress model for predicting CARPA and concludes that CARPA may become a frequent safety issue in the upcoming era of nanomedicines, necessitating its prevention at an early stage ofnanomedicine R&D.

TL;DR: The inception of layer-by-layer constructed particles facilitated the production of multifunctional, stimuli-responsive carrier systems and render these constructs extremely versatile in applications of sensing, encapsulation and target- and trigger-responsive drug delivery.

TL;DR: This review discusses the nucleation and growth of organic nanoparticles at high supersaturation, and presents process considerations for controlling supersaturations as well as physical and chemical routes for modifying API solubility to optimize supersaturation and control particle size.

TL;DR: A number of mechanisms by which the excipients interact with proteins in solution and with various interfaces, and their effects on the physical properties of the dried protein structure are described, and how the various interaction forces are related to their observed effects on protein stability are explained.

TL;DR: This review discusses magnetic formulations of vectors for nucleic acid delivery and their characterization, mechanisms of magnetofection, and the application of magnet ofection in viral and nonviral nucleic acids delivery in cell culture and in animal models.

TL;DR: PLGA-NPs containing antigens along with immunostimulatory molecules (adjuvants) can not only target antigen actively to DCs, but also provide immune activation and rescue impaired DCs from tumor-induced immuosupression.

TL;DR: This review will focus on various targeted prodrug designs that have been developed to increase the selectivity of chemotherapy drugs.

TL;DR: The chemical basis of these molecular concepts is put into perspective with the uptake and intracellular activation mechanisms, the in vitro and in vivo proofs of concepts and the clinical results.

TL;DR: Key requirements and properties of these substrates, as well as methods and readout parameters to test their efficacy in the human body, are described in detail and discussed in the light of current trends toward designing biologically inspired microenviroments for in situ tissue engineering purposes.

TL;DR: Electrospinning is a versatile technique in tissue engineering for the production of scaffolds that enables cell proliferation and ingrowth, whereas fiber diameter predominantly influences cell fate, and pore size is far more relevant as a structural parameter than previously recognized.

TL;DR: This article comprehensively reviews the most recent trends in graphene-based biosensors and attempts to identify the future directions in which the field is likely to thrive.