Showing papers in "Advanced Drug Delivery Reviews in 2012"

TL;DR: Building off a strong technology base and multiple demonstrations of successful drug delivery, microneedles are poised to advance further into clinical practice to enable better pharmaceutical therapies, vaccination and other applications.

TL;DR: The protective barrier properties of mucus secretions, how mucus affects the fate of orally administered nanoparticles, and recent developments in nanoparticles engineered to penetrate the mucus barrier are addressed.

TL;DR: This review gives a brief overview about some types of stimuli-responsive nanocarriers with the main focus on organic polymer-based systems.

TL;DR: An overview of relevant nasal anatomy and physiology is given and the pathways and mechanisms likely involved in drug transport from the nasal epithelium to the CNS are discussed.

TL;DR: This review will discuss the barrier issue from a biological and pathological perspective to provide a better insight to the challenges and opportunities associated with the BBB.

TL;DR: This review aims to give a comprehensive summary of what is known today about nanoparticle toxicology, the mechanisms at the cellular level, entry routes into the body and possible impacts to public health.

TL;DR: Current progress in using gold nanorods as phototherapeutic agents and as drug delivery vehicles is summarized and issues of dosage, toxicity and biological interactions at three levels are discussed, concluding with recommendations for future work in this area.

TL;DR: In this review, several enzyme-responsive nanomaterials such as polymer-based nanoparticles, liposomes, gold nanoparticles and quantum dots are introduced, and the modulation of their physicochemical properties by enzymatic activity emphasized.

TL;DR: The role of various regenerative factors involved in bone healing and their appropriate combinations with different delivery systems for augmenting bone regeneration are discussed.

TL;DR: This review puts the spotlight on crosslinked polymer nanogels, a promising platform that has the characteristics of an "ideal" drug delivery vehicle, and points to the advantages that crosslinked polymeric systems bring to drug delivery.

TL;DR: An overview of the different approaches taken in the application of calcium phosphate cements for drug delivery in the skeletal system is provided, and the most significant achievements are identified.

TL;DR: This review covers two broad categories of particle functionalization, organic monolayers and biomolecule coatings, and discusses their applications in drug, DNA/RNA, protein and small molecule delivery.

TL;DR: This review provides an overview of metal-based anticancer drugs and drug candidates, focusing on metal complexes that can be activated in the reducing environment of cancer cells, thus serving as prodrugs.

TL;DR: The reflections on biomedical applications of dendrimers given in this review clearly demonstrate the potential of this new fourth major class of polymer architecture and indeed substantiate the high hopes for the future of dendedrimers.

TL;DR: This review covers five underlying photochemical mechanisms that govern the activity of the majority of photoresponsive nanocarriers and how they affect release, as well as the advantages and disadvantages of each system.

TL;DR: This review describes the current status of pH-sensitive vesicles, polymeric micelles, and nanospheres prepared with polycarboxylates and their performance as nano-scale drug delivery systems, with emphasis on the recent contribution to this field.

TL;DR: A review of the major advances in the development of polymeric nanoparticles for drug delivery to the CNS and how many of the polymers used in nanoparticle fabrication are both biodegradable and biocompatible increases the clinical utility of this strategy.

TL;DR: Although differential scanning calorimetry is the most widely used thermal analytical technique applied to the characterization of amorphous solid dispersions, there are many established and emerging techniques which have been shown to provide useful information.

TL;DR: Future development of CNS nanomedicines need to focus on increasing their drug-trafficking performance and specificity for brain tissue using novel targeting moieties, improving their BBB permeability and reducing their neurotoxicity.

TL;DR: A full evaluation on the toxicity, bio-distribution and immunology of these materials are envisaged to boost their application potentials.

TL;DR: It is clear that developing novel multifunctional nonviral vectors, which transform their physico-chemical properties in response to various stimuli in a timely and spatially controlled manner, is highly desired to translate the promise of gene therapy for the clinical success.

TL;DR: This work discusses how the interactions of nanomaterials with biological systems can guide their design for diagnostic, imaging and drug delivery purposes, and considerations for the development of personalized nanomedicines.

TL;DR: This report reviews some of the recent progress made for enhancing the biocompatibility of luminescent quantum dots and for developing targeted bio-inspired applications centered on live cell imaging and sensing and discusses issues of toxicity associated with the use of QDs in biology.

TL;DR: Given DBM's long clinical track record and commercial accessibility in standard forms and sources, opportunities to further develop and validate DBM as a versatile bone biomaterial in orthopedic repair and regenerative medicine contexts are attractive.

TL;DR: Trans-mucosal delivery is now a favoured route for non-parenteral administration of emergency drugs and agents where a rapid onset of action is required and advances in drug delivery technology are bringing forward the likelihood of transmucosal systemic delivery of biological agents.

TL;DR: This review aims to provide an in depth status of current MSC-based cancer therapies, as well as the prospects for their clinical translation.

TL;DR: Macrocyclic hosts of the cyclodextrin, sulfonatocalixarene, and cucurbituril type can be employed as discrete supramolecular drug delivery systems, thereby complementing existing supramolescular drug formulation strategies based on polymers, hydrogels, liposomes, and related microheterogeneous systems.

TL;DR: This article summarizes efforts to evaluate poly(amido amine) (PAMAM) dendrimers as carriers for oral drug delivery and the effect of PAMAM generation, surface charge and surface modification on toxicity, cellular uptake and transepithelial transport is discussed.

TL;DR: Developing of an implant in which an antibiotic tethered to the metal surface is used to prevent bacterial colonization and biofilm formation is described, showing a real potential to mitigate or prevent the devastating consequences of orthopaedic infection.