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Showing papers in "Advanced Drug Delivery Reviews in 2013"


Journal ArticleDOI
TL;DR: Lipidic nanoparticles are the first nanomedicine delivery system to make the transition from concept to clinical application, and they are now an established technology platform with considerable clinical acceptance.

3,497 citations


Journal ArticleDOI
TL;DR: A historical review of the EPR effect, including its features, vascular mediators found in both cancer and inflamed tissue, and methods of augmentation of theEPR effect are described, that result in better tumor delivery and improved therapeutic effect.

1,900 citations


Journal ArticleDOI
TL;DR: This review covers the current knowledge of fusion protein linkers and summarizes examples for their design and application and considers the general properties of linkers derived from naturally-occurring multi-domain proteins as the foundation in linker design.

1,371 citations


Journal ArticleDOI
TL;DR: The present article discusses the processing of silk fibroin into different forms of biomaterials followed by their uses in regeneration of different tissues.

994 citations


Journal ArticleDOI
TL;DR: Nanoparticles can overcome existing drug resistance mechanisms, including decreased uptake and increased efflux of drug from the microbial cell, biofilm formation, and intracellular bacteria, and target antimicrobial agents to the site of infection, thereby overcoming resistance.

992 citations


Journal ArticleDOI
TL;DR: In this review, this review focuses on the materials innovation and processing of drug delivery systems and how these advances have shaped the past and may influence the future of drug Delivery.

827 citations


Journal ArticleDOI
TL;DR: This review focuses on state of the art and recent advances in the construction of cyclodextrin-based assemblies and their applications for controlled drug delivery and the future directions of this field are discussed.

673 citations


Journal ArticleDOI
TL;DR: Of the cell types known to produce exosomes, the readily available proliferative, immunosuppressive and clinically tested human mesenchymal stem cell (MSC) is the most prolific producer.

620 citations


Journal ArticleDOI
TL;DR: This article briefly overviews the field of stimuli-responsive polymers and describes some of the most successful biomedical applications to date of such "smart" polymers.

615 citations


Journal ArticleDOI
TL;DR: This review aims to demonstrate the advantage of the young medical science field, nanomedicine, for overcoming cancer drug resistance with the advanced design and alternative mechanisms of drug delivery known for different nanodrugs.

581 citations


Journal ArticleDOI
TL;DR: This review covers recent advances related to the therapeutic use of mesoporous silica nanoparticles administered intravenously, intraperitoneally or locally and critically discusses burning questions especially related to experimental design of in vivo studies to enable a fast transition to clinical trials of this promising drug delivery platform.

Journal ArticleDOI
TL;DR: This opinion paper relates how nanoparticles were discovered in the seventies and how the development of biodegradable materials and nanoparticle surface functionalization has allowed new treatment strategies to be developed.

Journal ArticleDOI
TL;DR: The conclusion that may be drawn from the analysis of the camptothecins is that approved drugs reformulated in polymeric and liposomal cancer nanomedicines have a more difficult time navigating through the approval process than the parent molecule.

Journal ArticleDOI
TL;DR: The delivery of small molecule drugs is expounded, with special attention paid to the current progress of in vitro and in vivo research involving CNT-based DDSs, before finally concluding with some consideration on inevitable complications that hamper successful disease intervention with CNTs.

Journal ArticleDOI
TL;DR: The purpose of the review is to assess state of the art and future perspectives of the so called "smart biomaterials" from a translational science and specifically clinical point of view and to filter out and discuss which biomedical advances and innovations help to achieve the objective to translate smart biomMaterials from bench to bedside.

Journal ArticleDOI
TL;DR: It is described how these natural carriers of genetic material can be harnessed to overcome the obstacle of poor delivery and allow efficient systemic delivery of exogenous siRNA across biological barriers such as the blood-brain barrier.

Journal ArticleDOI
TL;DR: The state of the art of crosslinked ionic polysaccharides as components of delivery systems that can regulate drug release as a function of changes in pH, ion nature and concentration, electric and magnetic field intensity, light wavelength, temperature, redox potential, and certain molecules are analyzed.

Journal ArticleDOI
TL;DR: An overview of the methods of preparation, the properties, the performances as drug delivery systems and as scaffolds for tissue engineering, of (semi)-IPNs obtained using alginate and hyaluronic acid are given.

Journal ArticleDOI
TL;DR: Unique features that make QDots an ideal platform for nanocarrier design are outlined and how this model has been applied to study NDD vehicle behavior for diverse drug delivery applications are discussed.

Journal ArticleDOI
TL;DR: The mechanisms governing the major modes of receptor-mediated endocytosis used in drug delivery are outlined and recent approaches using these as targets for in vivo drug delivery of nanoparticles are highlighted.

Journal ArticleDOI
TL;DR: Advances in synthetic polymer chemistry, the move towards greater use of biodegradable polymers, polymers delivering combination therapy, increased understanding of polymer therapeutic critical product attributes to guide pharmaceutical development, and advances in understanding of endocytosis and intracellular trafficking pathways in health and disease are opening new opportunities for design and clinical use of polymer-based therapeutics in the decades to come.

Journal ArticleDOI
TL;DR: The synthesis of CS derivatives and their characteristics, as well as their potential transport mechanisms of macromolecular therapeutics across the intestinal biological membrane, are described.

Journal ArticleDOI
TL;DR: The transport mechanism of the GI tract, barriers to protein absorption, current status and limitations of nanotechnology for oral protein delivery system are reviewed.

Journal ArticleDOI
TL;DR: An extensive analysis of recent efforts to mimic functional nanostructures in vitro for improved tissue engineering and regeneration of injured and damaged tissues shows that the nanotopography itself can activate tissue-specific function in vitro as well as promote tissue regeneration in vivo upon transplantation.

Journal ArticleDOI
TL;DR: Recommendations for ligand-targeted PNM approaches include the delivery of drugs that are unable or inefficient in passing cellular membranes, treatment of drug resistant tumors, targeting of the tumor blood supply, the generation of targeted vaccines and nanomedicines that are able to cross the blood-brain barrier.

Journal ArticleDOI
TL;DR: This review presents an overview of the state-of-the-art multiphase flow microfluidics for the production of single emulsions or multiple emulsion droplets for drug delivery.

Journal ArticleDOI
TL;DR: This review highlights current understanding on the pharmacology and limitations of platinum compounds in clinical use, and provides a comprehensive analysis of various platinum-polymer complexes, micelles, dendrimers, liposomes and other nanoparticles currently under investigation for delivery of platinum drugs.

Journal ArticleDOI
Qi Yin1, Jianan Shen1, Zhiwen Zhang1, Haijun Yu1, Yaping Li1 
TL;DR: In this review, the applications of DDS which is responsive to different types of stimuli in MDR cancer therapy is introduced, and the design, construction, stimuli-sensitivity and the effect to reverse MDR of the stimuli-responsive DDS are discussed.

Journal ArticleDOI
TL;DR: This review article reviews the latest advancements of optical carbon nanotube based biosensors with a special focus on near-infrared (NIR)-fluorescence, Raman-scattering and fluorescence quenching.

Journal ArticleDOI
TL;DR: This overview focuses on bioconjugates of water-soluble polymers with low molecular weight drugs and proteins, a new paradigm in drug delivery, and research directions needed for the acceleration of the translation of nanomedicines into the clinic are outlined.