Showing papers in "Advanced Drug Delivery Reviews in 2016"

TL;DR: The history of the development of PEGylated nanoparticle formulations for systemic administration is described, including how factors such as PEG molecular weight, PEG surface density, nanoparticle core properties, and repeated administration impact circulation time.

TL;DR: The main purpose of this review is to elaborate the mechanical and physical properties that affect PLA stability, processability, degradation, PLA-other polymers immiscibility, aging and recyclability, and therefore its potential suitability to fulfill specific application requirements.

TL;DR: The complex ECM structure is emphasized as to provide a better understanding of its dynamic structural and functional multipotency and the implication of the various families of ECM macromolecules in health and disease is presented.

TL;DR: A review of the current status of PLA mass production, processing techniques and current applications is presented, and the methods to tailor PLA properties, the main PLA degradation reactions, PLA products' end-of-life scenarios and the environmental footprint are covered.

TL;DR: Recent progress and remaining challenges in the development of EVs as drug delivery vehicles are reviewed and discussed.

TL;DR: PLA's application as drug-loaded nanoparticle drug carriers, such as liposomes, polymeric nanoparticles, dendrimers, and micelles, can encapsulate otherwise toxic hydrophobic anti-tumor drugs and evade systemic toxicities.

TL;DR: This review highlights recent developments, current results and trends in the field of composites based on PLA, presents the main advances in PLA properties and reports selected results in relation to the preparation and characterization of the most representative PLA composites.

TL;DR: Graphene and its chemical derivatives have been a pivotal new class of nanomaterials and a model system for quantum behavior and the opportunities in the usage of graphene-based materials for clinical applications are outlined.

TL;DR: This review surveys the most recent advances in combination delivery of multiple small molecule chemotherapeutics using nanocarriers and highlights the sequential and site-specific co-delivery strategies, which provide new guidelines for development of programmable combination drug delivery systems.

TL;DR: The macrophage is known to be a multifunctional antigen presenting cells and playing a central role in inflammation, and infiltrating TAMs themselves or polarization pathway of TAMs are considered as new therapeutic targets for the therapy of malignant tumors.

TL;DR: The rationale underlying approaches, chemical strategies, and recent advances in the use of HA to design drug carriers for delivering anticancer agents, are reviewed and descriptions are given of HA-based drug conjugates, particulate carriers, inorganic nanostructures, and hydrogels.

TL;DR: The Rule of 5 methodology appears to be as useful today in defining drugability as when it was proposed, but recognizing that the database that was used includes only drugs that successfully reached the market, it is not view additional criteria necessary.

TL;DR: The antibacterial mechanism of graphene is highlighted and recent advances related to the antibacterial activity of graphene-based materials are summarized and many of the recent application examples are further discussed.

TL;DR: The process of inflammatory reaction that is to be expected following implantation of PLA is reviewed, and specific cases in which the inflammatory reaction can result in safety concerns are highlighted.

TL;DR: This review aims to provide an overview of developing multi-modal therapies using nanomaterials ("combo" nanomedicine) along with the rationale, up-to-date progress, further considerations, and the crucial roles of interdisciplinary approaches.

TL;DR: A decade of progress in investigation of PLA SCs is summarized and a wide variety of SCs other than PLA SC are found to have been formed in the enantiomeric substituted PLA blends and stereo block substituted PLA polymers.

TL;DR: The opportunities for PLA blends in the biomedical arena are discussed, including the overview of blending and postblend processing techniques and the applications of PLA blends currently in use and under development.

TL;DR: Graphene-based nanosystems exhibit multifunctional properties that are useful for PTT applications including enhancement of multimodalities, guided imaging, enhanced chemotherapy and low-power efficient PTT for optimum therapeutic efficiency.

TL;DR: The opportunities and predictivity of various in vitro systems with special emphasis on human intestine in Ussing chambers are discussed, and characteristics of common in vitro cell culture systems are discussed and compared to those of human intestinal tissues.

TL;DR: The basic background of ASDs, various formulation and process variables influencing the critical quality attributes (CQAs) of the ASDs and aspects of downstream processing are discussed and recent advances in the spray-based drying techniques are mentioned.

TL;DR: The current status of clinical trials related to siRNA-based cancer therapy is described, as well as the remaining issues that need to be overcome to establish a successful therapy, and various promising design strategies of delivery vehicles for stable and targeted siRNA delivery are introduced.

TL;DR: This study investigates co-amorphous formulations from the viewpoint of solid dispersions, describes their formation and mechanism of stabilization, study their impact on dissolution and in vivo performance and briefly outline the future potentials.

TL;DR: The recent advances in the development of nano-graphene as stimuli-responsive nano-carriers for drug delivery, as well as the applications of these smart systems for cancer therapy are summarized.

TL;DR: This review provides a summary of current approaches that employ ECM and ECM-like materials, orECM-synthetic polymer hybrids, as biomaterials in the field of regenerative medicine and discusses the utilization of such materials for cell and drug delivery, and highlight strategies for their use as vehicles for cancer therapy.

TL;DR: How diverse and heterogeneous functions given by CAFs can exert potent influences on tumor progression and therapeutic response is highlighted and the current advances in the development of novel therapeutic strategies against CAFs are discussed.

TL;DR: Recent developments in PLA-based biomaterials with respect to processability and current applications in the clinical and research settings for bone, ligament, meniscus, and cartilage regeneration are discussed.

TL;DR: The rule of five (Ro5), based on physicochemical profiles of phase II drugs, is consistent with structural limitations in protein targets and the drug target ligands and is a strong contributor to NP Ro5 outliers.

TL;DR: Designing LNPs requires the striking of a proper balance between the need for particle stability, long systemic circulation time, and theneed for LNP destabilization inside the target cell to release the oligonucleotide cargo, which requires the proper selection of both the cationic and helper lipids.

TL;DR: The review focuses on the method of nanoparticle formation (self-assembled, physical or chemical cross-linked) when engineering polysaccharide-based nanoparticles for theranostic nanomedicine.

TL;DR: The latest advances in the use of PLA nanofibrous scaffolds for musculoskeletal, nervous, cardiovascular, and cutaneous tissue engineering are presented and perspectives on their future use are offered.