Showing papers in "Advanced Drug Delivery Reviews in 2021"

TL;DR: In this paper, the virology and immunology of SARS-CoV-2, alternative therapies for COVID-19 to vaccination, principles and design considerations in vaccine development, and the promises and roles of vaccine carriers in addressing the unique immunopathological challenges presented by the disease.

TL;DR: In this article, the impact of composition on liposome synthesis, function, and clinical utility is discussed, as well as the role of composition of liposomes in drug delivery.

TL;DR: In this article, a review of the design and self-assembly of mRNA vaccines is presented, highlighting the materials commonly utilized to deliver mRNA, their physicochemical characteristics, and other relevant considerations, such as mRNA optimization, routes of administration, cellular fate, and immune activation, that are important for successful mRNA vaccination.

TL;DR: A few of the leading non-viral vaccines that are under clinical stage development are introduced and delivery strategies to improve vaccine efficacy, duration of protection, safety, and mass vaccination are discussed.

TL;DR: In this article, the most advanced cases of localized delivery of liposomal formulations of drugs, which have been investigated pre-clinically and clinically in the last ten years, together with the reported therapeutic advantages, in each case.

TL;DR: In this article, the authors summarized the points of scaffold design as well as applications for bone regeneration based on both electrospinning and 3D bioprinting for osteogenesis.

TL;DR: In this article, the authors highlight two main areas where supramolecular binding motifs are being used in the design of drug delivery systems: engineering network mechanics and tailoring drug-material affinity.

TL;DR: The features of plasmid-, RNA- and ribonucleoprotein-based CRISPR-Cas therapeutics are summarized, the requirements for efficient in vivo delivery in clinical settings are specified, and both efficiency and safety for different CRISpr-Cas tools are highlighted.

TL;DR: In this review, recent developments in DNA hydrogels and their applications in drug delivery systems are highlighted, and physical and chemical crosslinking methods for constructing DNA Hydrogels are introduced.

TL;DR: A review of the latest cutting-edge investigations in 3D printing pharmaceuticals in the pre-clinical and clinical arena and a forward-looking approach towards strategies to further aid the translation of 3D printed pharmaceuticals into the clinic is provided in this paper.

TL;DR: This review outlines fibronectin splice variants and their functions, evaluates potential therapeutic strategies targeting or utilizing fibronECTin, and concludes by discussing potential future directions to modulate fibronctin function in development and wound healing.

TL;DR: Delivery of CRISPR/Cas systems by physical methods, viral vectors and non-viral vectors for cancer gene therapy and immunotherapy and promising advances in cancer treatment using CRISpr/ Cas systems are discussed.

TL;DR: In this article, the authors provide an overview on AMPs and their synthetic mimics, and then discuss the current status of their clinical translation, highlighting the recent advances in redesign and repurposing of AMP and SMAMPs.

TL;DR: In this paper, a comprehensive review evaluates the current and emerging therapies including those in clinical trials that may potentially improve both targeted delivery of therapeutics directly to the tumour site and the development of agents that may specifically target GBM.

TL;DR: Powder bed fusion (PBF) is a 3D printing method that selectively consolidates powders into 3D objects using a power source as mentioned in this paper, which can be used for the fabrication of bespoke drug-laden formulations, devices and implants.

TL;DR: In this article, the authors examined 64 pre-clinical studies for extracellular vesicles (EV) based therapeutics with respect to their applied EV dosing strategies and found dose discrepancies depending on the disease model, where EV doses were selected without accounting for published EV pharmacokinetics or biodistribution patterns.

TL;DR: In this paper, the authors discuss several therapeutic applications of nucleic acids directed towards specific diseases and tissues of interest, in particular highlighting recent technologies which have reached late-stage clinical trials and received FDA approval.

TL;DR: In this paper, the most important biological barriers that can be tackled using ultrasound and aims to provide insight on how ultrasound has shown to improve accessibility as well as the biggest hurdles, and discuss the clinical applicability of therapeutic ultrasound with respect to the main challenges.

TL;DR: In this paper, extracellular vesicles (EVs) have emerged as an attractive drug delivery system and the authors assess their pre-clinical applications, in the form of a systematic review.

TL;DR: A review of recent advances in photo-sensitive drug delivery can be found in this article, where the authors discuss recent innovations in photosensitive drug delivery and highlight future opportunities to engineer and exploit such light-responsive technologies in the clinical setting.

TL;DR: A review of the most promising healthcare technologies and devices, their strengths, drawbacks, and opportunities for clinical adoption can be found in this paper, where the authors highlight the potential of the Internet of Things (IoT) technology to enable seamless integration within healthcare.

TL;DR: In this paper, the authors provide an overview of the preclinical and clinical data on SARS-CoV-2 vaccines that are currently in Phase III clinical trials and in few cases authorized for emergency use.

TL;DR: The action mechanisms of CRISPR/Cas9 are presented, its application in cancer therapy is presented, and the nanotechnology-based delivery of CRisPR/cas9 for cancer gene editing and immunotherapy is focused on to pave the way for its clinical translation.

TL;DR: The approach and requirements for a successful vaccine against SARS-CoV-2, the background of the myriad of vaccine platforms currently in clinical trials for COVID-19 prevention, and a summary of the present results of those trials are addressed.

TL;DR: The authors in this paper presented the opinion of UNGAP scientists on four key themes across the oral absorption landscape: (1) specific patient populations, (2) regional differences in the gastrointestinal tract, (3) advanced formulations and (4) food-drug interactions.

TL;DR: Polymeric nanoparticles have provided a promising platform that can efficiently encapsulate versatile NASMs, overcome multiple drug delivery barriers, and orally deliver the loaded NASMs to targeted tissues or cells while enhancing their stability and bioavailability.

TL;DR: A comprehensive overview on a holistic polymer-AM perspective for drug delivery systems with discussion on the materials, properties, design and fabrication techniques and the mechanisms used to achieve a controlled release system is provided in this article.

TL;DR: The role played by nanocarrier delivery in the SARS-CoV-2 global pandemic has been summarized in this article, with a focus on the role played in the role of delivery.

TL;DR: Extracellular vesicles (EVs) are biological nanoparticles naturally secreted by cells, acting as delivery vehicles for molecular messages as discussed by the authors, and have been assigned multiple functions that have established their potential as therapeutic mediators for a variety of diseases and conditions.

TL;DR: A recent review as discussed by the authors summarizes recent progress in the development of nanomaterials and their applications to improve atherosclerosis diagnosis and therapy during the preclinical and clinical stages of the disease.