Showing papers in "American Journal of Kidney Diseases in 1999"

TL;DR: There remains a critical need to establish optimal therapeutic strategies and targets to improve clinical outcomes in patients with progressive renal disease, and the important modifiable risk factors are defined.

TL;DR: It is argued that the challenge for the future will be better patient management in earlier phases of diabetic nephropathy to attenuate or prevent progression, as well as cardiovascular complications.

TL;DR: The strikingly elevated mortality risk with lowpredialysis systolic BP suggests that low predialysis BP needs to be viewed with great concern and avoided where possible, and greater attention to postdialysis hypertension is suggested.

TL;DR: Overall, within the first 2 years of therapy, short-term CAPD/CCPD appears to be associated with superior outcomes compared with hemodialysis, and it appears that patients on the two therapies have different mortality patterns over time, a nonproportionality that makes survival analyses vulnerable to the length of follow-up.

TL;DR: It is concluded that the partial correction of SHPT with intravenous calcitriol causes a regression in myocardial hypertrophy without biochemical or hemodynamic changes, such as heart rate, BP, and TPR.

TL;DR: It is concluded that low lumbar-spine BMD might be a sensitive predictor of vertebral fractures in hemodialysis patients, and patients with relatively low iPTH levels would have a greater risk for vertebral fracture than those with hyperparathyroidism.

TL;DR: In well-dialyzed patients who were iron replete, the acute-phase response was the most important predictor of EPO resistance, and EPO/Hct was independent of PTH and aluminum levels, PCRn, and Kt/V.

TL;DR: Results show that the intake of Chinese herbs containing AA has a dramatic carcinogenic effect and is associated with the overexpression of p53, which suggests a role for a p53 gene mutation.

TL;DR: It is concluded that in chronic hemodialysis units, CAB is relatively common and frequently involves gram-negative bacteria and PC salvage is significantly improved when antibiotic treatment is combined with PC exchange over a guidewire.

TL;DR: The cumulative projected 10-year cost of all side effects for a 50-patient cohort was $265, 900, or $5,300 per transplant patient, providing a rationale for further investigation of steroid-sparing immunosuppression protocols.

TL;DR: In this review, an attempt is made to clarify the nature and severity of risks in the settings of chronic renal insufficiency and end-stage renal disease, including dialysis patients and transplant recipients.

TL;DR: Improved understanding of the effects of currently used immunosuppressive medicines on glycemic tolerance is of interest in clinical transplantation.

TL;DR: Sevelamer was effective in controlling hyperphosphatemia without resulting in an increase in the incidence of hypercalcemia seen with calcium acetate, and its usage may be advantageous in the treatment of dialysis patients.

TL;DR: This article suggests that hyperuricemia may be mediated by intrarenal ischemia with lactate generation and the inhibition of the secretion of urate by the anion-exchange transport system, and further studies are necessary to rule out a pathogenic role for uric acid in the development of renal disease and salt-dependent hypertension.

TL;DR: It is suggested that further correction of anemia to normal Hct levels may result in continued improvement in neurocognitive function by improving the able to sustain attention in easier tasks and by enhancing the ability to recognize, discriminate, and hold stimuli in memory for more difficult tasks.

TL;DR: This study provides first-time evidence that the combination of CEI and LOS in normotensive patients with IgA nephropathy produces a more profound decrease in proteinuria than either drug.

TL;DR: The results suggest that neutrophils and adhesion molecules play an important role in mediating tissue injury with subsequent renal failure, and that chronic renal failure reduces neutrophil function and thereby can increase susceptibility to infection and sepsis.

TL;DR: It is concluded that an intensive-care, specific-treatment schedule reduces mortality in multivisceral cholesterol embolism.

TL;DR: It is concluded that peritoneoscopically placed PD catheters have a longer survival rate than surgically placed ones and the rate of exit site leak and early infection is lower in the peritoneoscopic method.

TL;DR: Using sodium ferric gluconate complex in sucrose, when compared with iron dextrans in comparably sized patient usage populations with similar total rates of reporting of allergic events, has a significantly lower reported mortality rate (P < 0.001).

TL;DR: It is demonstrated that convection is more efficient than diffusion in removing mixed-molecular-weight solutes during venovenous continuous renal replacement therapy (CRRT).

TL;DR: RHuEPO therapy with full correction of anemia reduces PLMS, arousals from sleep, and sleep fragmentation while allowing for more restorative sleep and improved daytime alertness, which may explain one mechanism for the improved quality-of-life parameters reported in ESRD patients treated with rHuEPO.

TL;DR: The results of this study validate angioplasty and AVL as therapy for the salvage of AVFs that fail to develop and access was salvaged in 52 patients (82.5%).

TL;DR: These studies suggest that hypertensive individuals with microalbuminuria manifest a variety of biochemical and hormonal derangements with pathogenic potential, which results in hypertensive patients having a greater incidence of cardiovascular events and a greater decline in renal function than patients with normal UAE.

TL;DR: The analysis of demographic and laboratory data confirmed the importance of age and serum albumin concentration as predictors of death and suggested that RRF and peritoneal clearance may be separate and not equivalent quantities.

TL;DR: Data show that the glomerular permeability test has a significant predictive value for the recurrence of proteinuria in children with FSGS who have received a renal allograft.

TL;DR: Glut1 is the first gene whose rate of transcription has been shown to be dually regulated by hypoxia, and it is supported by the finding that exposure of a variety of cells and tissues to agents such as azide or cyanide, in the presence of oxygen, also leads to stimulation of glucose transport.

TL;DR: In patients with type 1 diabetes mellitus and diabetic nephropathy, the MAP goal should be 92 mm Hg or less for optimal renoprotection, if defined as including decreased proteinuria, and with the combination of ACE inhibition and intensive blood pressure control, many patients can achieve regression or apparent remission of clinical evidence of diabetic neephropathy.

TL;DR: The data suggest that captopril decreases TGF-beta1 levels in diabetic nephropathy and that changes in TGF ( transforming growth factor-beta) levels may predict the course of diabetic neephropathy.