Showing papers in "American Journal of Kidney Diseases in 2008"

TL;DR: Serum cystatin C level alone provides GFR estimates that are nearly as accurate as serum creatinine level adjusted for age, sex, and race, thus providing an alternative GFR estimate that is not linked to muscle mass.

TL;DR: The results provide important information about mineral metabolism trends in hemodialysis patients in 12 countries during a decade and may be relevant to efforts at international harmonization of existing clinical guidelines for mineral metabolism.

TL;DR: NGAL levels predict the future appearance of acute kidney injury after treatments potentially detrimental to the kidney and even the acute worsening of unstable nephropathies, and recent evidence suggests that NGAL somehow may be involved in the pathophysiological process of chronic renal diseases.

TL;DR: Clinical information about the incidence of hyponatremia associated with specific drug treatment is reviewed and the underlying pathophysiologic mechanisms are discussed.

TL;DR: Obesity is associated with increased risk of developing stage 3 CKD, which was no longer significant after adjustment for known cardiovascular disease risk factors.

TL;DR: In US adults, lower levels of kidney function are associated with an increased prevalence of cognitive impairment, which appears to increase early in the course of kidney disease; therefore, screening for impairment should be considered in all adults with CKD.

TL;DR: This hypothesis-generating meta-analysis suggests that early initiation of RRT in patients with ARF might be associated with improved survival, calling for an adequately powered randomized controlled trial to address this question.

TL;DR: ECD kidneys have worse long-term survival than standard criteria donor kidneys and patients younger than 40 years or scheduled for kidney retransplantation should not receive an ECD kidney, based on the available evidence.

TL;DR: With intensive lowering of LDL-C levels for 1 year, hemodialysis patients treated with either calcium acetate or sevelamer experienced similar progression of CAC.

TL;DR: There is impaired recovery of kidney function after AKI in aged individuals and future studies should be cognizant of "age" as a potential effect modifier in the prognosis after AKi, and clinical trials should focus on improving outcomes in the elderly cohort.

TL;DR: Fatigue is an important and often underrecognized symptom in the dialysis population and possible interventions for minimizing fatigue in patients on long-term dialysis therapy should aim at improving health care provider awareness, developing improved methods of measurement, understanding the pathogenesis better, and managing known contributing factors.

TL;DR: Kidney function and indicators of kidney damage were based on single measurements and factors independently associated with decreased kidney function included older age, history of cardiovascular disease, and hypertension status.

TL;DR: Urinary NGAL has limited diagnostic accuracy to predict AKI defined by change in serum creatinine after cardiac surgery, and level correlated significantly with cardiopulmonary bypass and aortic cross-clamp times.

TL;DR: In this paper, the authors describe the predictors of rapid progression of kidney disease and death in patients followed up by nephrologists, including the index estimated glomerular filtration rate less than 30 mL/min/1.73 m 2.

TL;DR: The pathological characteristics, pathogenesis, and various clinical entities of osmotic nephrosis are discussed.

TL;DR: The results agree with current recommendations for IV iron replacement for patients with CKD stage 5D and support increased use of IV iron for patientswith CKD stages 3 to 5.

TL;DR: Waist-to-hip ratio, but not BMI, is associated with incident CKD and mortality, and assessment of CKD risk should use WHR rather than BMI as an anthropomorphic measure of obesity.

TL;DR: Metabolic syndrome traits are associated with a self-reported history of kidney stones and this association should be verified in prospective studies.

TL;DR: Although data suggest that adding MRBs to ACE-inhibitor and/or ARB therapy yields significant decreases in proteinuria without adverse effects of hyperkalemia and impaired renal function, routine use of MRBs as additive therapy in patients with chronic kidney disease cannot be recommended yet.

TL;DR: Atrial fibrillation is associated with greater total and cardiovascular mortality and angiotensin-converting enzyme (ACE)-inhibitor treatment and comorbid conditions on hospitalization, and results for treatment need confirmation in future trials.

TL;DR: The finding that anxiety disorders negatively impact on QOL and are not merely manifestations of depression in patients with ESRD emphasizes the importance of accurate diagnosis and effective treatment.

TL;DR: The high ACE/ACE2 ratio in kidneys of patients with type 2 diabetes with overt nephropathy may contribute to renal injury.

TL;DR: The targeted nature of the KEEP screening program and the large sample size with clinical characteristics comparable to NHANES validates KEEP as a valuable cohort to explore health associations for the CKD and at-risk-for-CKD populations in the United States.

TL;DR: Glomerular and vascular changes are present before progression to overt proteinuria and decreased glomerular filtration rate, and may constitute a clinical and morphological combination heralding a potentially progressive renal disease.

TL;DR: It is confirmed that antibiotic locking solutions reduce the frequency of CRI without significant side effects and there was no evidence of antibiotic resistance developing during a maximum follow-up of 12 months.

TL;DR: Use of an ARB may be effective in reducing nonfatal CVD events in patients undergoing long-term HD, and a larger study is required to confirm these results.

TL;DR: Although distributions of hypertension were similar between databases, KEEP participants with cardiovascular risk factors have a greater prevalence of hypertension than similar NHANES participants, and study group participants younger than 46 years were more likely to have achieved goal blood pressure.

TL;DR: Treatment with sevelamer versus calcium-based binders did not affect overall mortality, cause- specific mortality, morbidity, or first or cause-specific hospitalization (primary outcomes), but there was evidence for a beneficial effect on multiple all-cause hospitalizations and hospital days (secondary outcomes).

TL;DR: Serum cystatin C level is related to sex and ethnicity, even in young healthy individuals and increases dramatically with age, reaching greater than 50% after the age of 80 years in both sexes and all ethnic groups.