Showing papers in "American Journal of Kidney Diseases in 2012"

TL;DR: The 2012 update of the Kidney Disease Outcomes Quality Initiative (KDOQI) Clinical Practice Guideline for Diabetes and Chronic Kidney disease (CKD) is intended to assist the practitioner caring for patients with diabetes and CKD.

TL;DR: Allan J. Collins, MD, Robert N. Foley, MB, Blanche Chavers,MD, David Gilbertson, PhD, Charles Herzog, MD and Kirsten Johansen, MD are authors of this book.

TL;DR: In tertiary-care pediatric ICU patients, ∼10% develop CKD 1-3 years after AKI, which may be higher with further follow-up because several patients were identified as being at risk of CKD.

TL;DR: Native kidney biopsy using automated biopsy devices and real-time ultrasonography is associated with a relatively small risk of macroscopic hematuria and erythrocyte transfusion requirement, and using smaller gauge needles may lower complication rates.

TL;DR: These findings highlight the possibility that stable kidney disease progression can accelerate and provide hope that CKD need not be relentlessly progressive and should encourage researchers to identify time-dependent factors associated with periods of nonprogression and other desirable trajectories.

TL;DR: This is the first study showing that inactive MGP levels can be decreased markedly by daily vitamin K(2) supplementation, and provides the rationale for intervention trials aimed at decreasing vascular calcification in hemodialysis patients by vitamin K supplementation.

TL;DR: Evidence from uncontrolled studies and small randomized controlled trials shows that exercise training results in improved physical performance and functioning in patients with CKD, and exercise appears to be safe in this patient population if begun at moderate intensity and increased gradually.

TL;DR: Frailty is relatively common in middle-aged patients with CKD and is associated with lower eGFR(cys) and increased risk of death or dialysis therapy, and this study estimated kidney function using serum cystatin C concentrations to minimize confounding due to relationships of serum creatinine levels with muscle mass and frailty.

TL;DR: Agricultural work on lowland sugarcane and cotton plantations was associated with decreased kidney function in men and women, possibly related to strenuous work in hot environments with repeated volume depletion.

TL;DR: Communication interventions that acknowledge the role of patient emotion and address uncertainty may improve how nephrologists discuss disease trajectory with patients and thereby enhance their understanding and preparation for the future.

TL;DR: The CRIC GFR estimating equation predicts mGFR accurately in the CRIC cohort using serum creatinine and cystatin C levels, age, sex, and race, and its performance was best in younger and healthier participants.

TL;DR: Taking in sum, these elements stress that initiating treatment at an early age is essential for reducing long-term morbidity and mortality in children with CKD.

TL;DR: There is substantial heterogeneity in patterns of kidney function loss leading up to the initiation of long-term dialysis perhaps calling for a more flexible approach toward preparing for end-stage renal disease.

TL;DR: Hyponatremia in patients with cancer is associated with longer hospital stay and higher mortality, and whether long-term correction of hyponatremeia would improve these outcomes remains to be determined.

TL;DR: Complete recovery of kidney function after an episode of AKI in patients with normal baseline kidney function is associated with increased risk of the development of incident stage 3 CKD, but not all-cause mortality.

TL;DR: The spectrum of renal lesions in multiple myeloma is more heterogeneous than previously reported and clinical features favoring amyloidosis over MIDD include older age, absence of kidney failure, presence of nephrotic syndrome, absenceof hematuria, and >50% albuminuria.

TL;DR: Longer survival and better nutritional status were observed for maintenance HD patients prescribed phosphate binders and in facilities with a greater percentage of phosphate binder prescription.

TL;DR: Patients with type 2 diabetic nephropathy, characterized by decreased kidney function and significant proteinuria, are more likely to reach ESRD than die during 3 years' mean follow-up, and this has implications for predicting future renal replacement therapy requirements.

TL;DR: Citrate anticoagulation decreased the risk of bleeding with no significant increase in the incidence of metabolic alkalosis, and Hypocalcemia was more common in patients receiving citrate, although no clinical adverse event was reported in the included studies.

TL;DR: The addition of cystatin C, BTP, and B2M levels to models including eGFR(CKD-EPI) and all covariates, including urinary albumin-creatinine ratio, significantly improved risk prediction for all outcomes (P < 0.001).

TL;DR: Lower serum sodium levels are associated with certain hemodialysis patient characteristics and higher adjusted risk of death and may be related to intradialytic cardiovascular stability, and deserves further study.

TL;DR: Kidney donation has a profound and multifaceted impact on the lives of donors and requires them to renegotiate their identity, roles, and relationships and strategies to safeguard against unwarranted coercion are needed.

TL;DR: Depressive symptoms in CKD are independent predictors of adverse clinical outcomes, including faster eGFR decrease, dialysis therapy initiation, death, or hospitalization, and should be evaluated early and treated in patients with CKD.

TL;DR: Maintenance hemodialysis patients with albumin levels ≤3.5 g/dL who received monitored intradialytic oral nutritional supplements showed survival significantly better than similar matched patient controls, with the as-treated analysis highlighting the potentially large effect of this strategy in clinical practice.

TL;DR: The ability to accurately predict individual patient-level risk currently is limited, and further research into additional biomarkers or risk prediction tools is needed to improve the care of patients with IgA nephropathy.

TL;DR: A structured program shows safety and feasibility in starting PD in patients with kidney failure who present without a plan for dialysis modality, and the steps laid out in this report can provide the framework for creating local urgent-start PD programs.

TL;DR: In hyperphosphatemic patients with stage 4 CKD, treatment with phosphate lowering induces measurable improvements in flow-mediated vasodilatation, compatible with the hypothesis that FGF-23 may contribute to vascular dysfunction in this population.

TL;DR: In HIV-infected persons, ESRD risk appears attributable to a combination of traditional and HIV-related risk factors for kidney disease, and combining eGFR and proteinuria for chronic kidney disease staging is most effective for stratifying the risk of E SRD.

TL;DR: The associations of mesangial hypercellularity and tubular atrophy/interstitial fibrosis with kidney disease outcomes were confirmed, and the inclusion criteria and statistical analysis were similar to the Oxford study.

TL;DR: Sleep disturbances may represent a novel risk factor for the development and progression of chronic kidney disease and optimizing sleep duration and quality and treating sleep disorders may reduce the severity and delay the progression of CKD