Showing papers in "American Journal of Transplantation in 2003"

TL;DR: High incidences of PTDM are associated with the type of initial maintenance immunosuppression, race, ethnicity, obesity and hepatitis C infection, and it is a strong, independent predictor of graft failure and mortality.

TL;DR: This article presents international consensus criteria for and classification of AbAR developed based on discussions held at the Sixth Banff Conference on Allograft Pathology in 2001, to be revisited as additional data accumulate in this important area of renal transplantation.

TL;DR: The authors’ analysis of risk factors for new-onset diabetes and its clinical implications provides valuable evidence on this important issue, and highlights the need for management strategies that minimize risk of diabetes developing after transplantation.

TL;DR: A large number of patients with prior organ transplants are likely to have had at least one prior organ transplant, and the results suggest that the number of previous transplants may have an important role in determining the prognosis.

TL;DR: A prospective cooperative study of 1629 patients in 24 centers demonstrated that antibodies foretold subsequent failures after a follow‐up period of 6 months (p’= 0.05).

TL;DR: While NodM had an incidence of approximately 6% per year among wait‐listed dialysis patients, NODM over the first 2 years post‐transplant had an occurrence of almost 18% and 30% among patients receiving cyclosporine and tacrolimus, respectively.

TL;DR: Insight is provided into the use of Campath‐1H induction in combination with rapamycin maintenance monotherapy in 29 primary human renal transplants and how the immunosuppressive regimen is modified in subsequent pilot studies.

TL;DR: There have been two recent trends in living kidney donation: increased acceptance of living donors and increasedacceptance of laparoscopic nephrectomy (LN).

TL;DR: Over time, more sensitive and specific lymphocyte crossmatch assays were developed that effectively decreased the incidence of early antibody-mediated rejection.

TL;DR: The prevalence of anemia in the transplant recipients was remarkably high and appeared to be associated with impaired renal function and with ACE inhibitors and angiotensin II receptor antagonist use.

TL;DR: It is concluded that specific genotypes of MDR1 and CYP3A5 in pediatric heart transplant patients require larger tacrolimus doses to maintain their tacolimus blood concentration, and that this information could be used prospectively to manage patient's immunosuppressive therapy.

TL;DR: It is concluded that NAS developed in ∼10% of primary liver transplant recipients, and a pretransplant diagnosis of autoimmune hepatitis has been identified as a novel independent risk factor for NAS formation.

TL;DR: It is suggested that selected crossmatch‐positive patients can be transplanted successfully with living‐donor kidney allografts, using a protocol of pretransplant plasmapheresis, intravenous immunoglobulin, rituximab and splenectomy.

TL;DR: There is strong evidence that maintenance CIN-MMFsteroid-based triple therapy, initiated in the early posttransplant period significantly reduces the risk of acute rejection in the first post-transplant year, when compared to double therapy regimens comprising CIN and steroids alone.

TL;DR: Short‐term outcomes have improved, based on the observation that rates of rejection within the first year post‐transplant have diminished, and use of antibody treatment for rejection during the first post-transplant year for most organs declined.

TL;DR: The use of sirolimus, tacrolimus and prednisone was associated with a greater incidence of lymphoceles, non‐lymphocele perinephric fluid collections and other consequences of poor wound healing, as compared to contemporary patients treated with MMF, tacrophenolate mofetil andprednisone.

TL;DR: These findings, together with the fact that the ligand for ovalbumin peptide‐specific CD8 T cells can be detected in Act‐mOVA tissues with an MHC‐restricted antibody, make this an ideal system for the study of cooperation between CD4 and CD8T cells.

TL;DR: It is concluded that accommodation is always present in well‐functioning, long‐surviving ABO‐incompatible kidney transplants and may involve several novel mechanisms including the disruption of normal signal transduction, attenuation of cellular adhesion and the prevention of apoptosis.

TL;DR: Increased levels of early alloreactivity measured with this ELISPOT assay may serve as a surrogate for chronic allograft dysfunction and show an independent correlation between early cellular allore activity and long‐term renal function.

TL;DR: The improved scoring system developed from a large population database provides a quantitative approach to evaluation of marginal kidneys and may improve allocation of these organs in cadaver renal transplantation.

TL;DR: Sirolimus appears to prolong DGF, and it may not be the optimal immunosuppressive choice in the DGF setting, but it retained its profound negative association with time to graft function in all multivariate models.

TL;DR: The incidence of C4d‐positive cases will probably decline because of the ‘routine’ application of potent immunosuppressants, including mycophenolate mofetil, that can inhibit antibody production, but Presensitization will remain a potential threat to allografts.

TL;DR: Preliminary data suggest that low‐dose cidofovir may be tolerated, even among renal transplant recipients with significant renal dysfunction due to BKVN, and Prospective, controlled trials are warranted to further define the optimal dose, toxicity and potential role of cid ofovir in renal transplant recipient with BK virus nephropathy.

TL;DR: Assessment of DC subsets and the pDC2 : pDC1 ratio showed good intra‐and interassay reproducibility and those in groups A and B demonstrated a significantly higher relative incidence of p DC2 and a lower incidence of PDC1 – similar to those values observed in normal healthy controls.

TL;DR: A retrospective cohort study of the prevalence of and factors associated with anemia among 240 patients who underwent kidney transplantation at an institution found awareness of Factors associated with a lower Hct may prompt better anemia screening and management, potentially improving cardiovascular outcomes among kidney transplant recipients.

TL;DR: The issues and recommendations regarding the waiting list for kidney transplantation addressed in the Philadelphia meeting are summarized.

TL;DR: Presented to The Society for Organ Sharing 2nd International Congress, Vancouver, BC, July 4–6, 1993.

TL;DR: A natural candidate for a surrogate marker for graft loss that has been proposed is renal function (serum creatinine or calculated GFR levels), and a research perspective, it has become increasingly difficult to study the efficacy of new therapies using traditional ‘hard’ endpoints.

TL;DR: The various immunomodulatory mechanisms attributable to IVIG and their efficacy in reducing PRAs will be described and the use of IVIG in solid organ transplant recipients will be reviewed.

TL;DR: The results indicate that the omental pouch is a viable site which offers a safe, convenient and efficacious alternative to the renal subcapsular space to transplant islets in rodents.