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JournalISSN: 0364-5134

Annals of Neurology

About: Annals of Neurology is an academic journal. The journal publishes majorly in the area(s): Multiple sclerosis & Epilepsy. It has an ISSN identifier of 0364-5134. Over the lifetime, 12145 publication(s) have been published receiving 1151265 citation(s). more

Topics: Multiple sclerosis, Epilepsy, Population more

Open accessJournal ArticleDOI: 10.1002/ANA.22366
Abstract: New evidence and consensus has led to further revision of the McDonald Criteria for diagnosis of multiple sclerosis. The use of imaging for demonstration of dissemination of central nervous system lesions in space and time has been simplified, and in some circumstances dissemination in space and time can be established by a single scan. These revisions simplify the Criteria, preserve their diagnostic sensitivity and specificity, address their applicability across populations, and may allow earlier diagnosis and more uniform and widespread use. more

8,100 Citations

Journal ArticleDOI: 10.1002/ANA.410130302
Abstract: Several schemes for the diagnosis and clinical classification of multiple sclerosis (MS) have been advanced [l}. The best known is that published by Schumacher et alC31. The criteria for this scheme were established in order to select patients for participation in therapeutic trials, and pertain only to what might be called definite MS. No provision was made for incorporating supportive laboratory data into the diagnostic criteria. As no reliable specific laboratory test for the diagnosis of MS has been discovered, the diagnosis remains a clinical one, and there is still a need for clinical diagnostic criteria. However, several laboratory and clinical procedures have been developed within the last decade which aid greatly in demonstrating neurological dysfunction attributable to lesions, and even the lesions themselves. One problem with the various published diagnostic classifications is their discrepant terminology: what is considered “probable” in one is called “definite” in another. Another problem is that all the proposed schemes require much subjective judgment, a difficulty which cannot be completely overcome but can be diminished by adding to the clinical evaluation the results of laboratory, neuroimaging, neuropsychological, and neurophysiological procedures. Today there is a need for more exact criteria than existed earlier in order to conduct therapeutic trials in multicenter programs, to compare epidemiological surveys, to evaluate new diagnostic procedures, and to estimate the activity of the disease process in MS. Method and Procedure more

Topics: Multiple sclerosis functional composite (64%), McDonald criteria (64%), Poser criteria (61%) more

7,457 Citations

Journal ArticleDOI: 10.1002/ANA.1032
W. Ian McDonald1, A Compston2, Gilles Edan, Donald E. Goodkin3  +12 moreInstitutions (15)
Abstract: The International Panel on MS Diagnosis presents revised diagnostic criteria for multiple sclerosis (MS). The focus remains on the objective demonstration of dissemination of lesions in both time and space. Magnetic resonance imaging is integrated with dinical and other paraclinical diagnostic methods. The revised criteria facilitate the diagnosis of MS in patients with a variety of presentations, including "monosymptomatic" disease suggestive of MS, disease with a typical relapsing-remitting course, and disease with insidious progression, without clear attacks and remissions. Previously used terms such as "clinically definite" and "probable MS" are no longer recommended. The outcome of a diagnostic evaluation is either MS, "possible MS" (for those at risk for MS, but for whom diagnostic evaluation is equivocal), or "not MS." more

Topics: McDonald criteria (67%), Poser criteria (62%), Clinically isolated syndrome (54%) more

6,453 Citations

Open accessJournal ArticleDOI: 10.1002/ANA.20703
Chris H. Polman1, Stephen C. Reingold, Gilles Edan2, Massimo Filippi3  +10 moreInstitutions (12)
Abstract: New diagnostic criteria for multiple sclerosis integrating magnetic resonance image assessment with clinical and other paraclinical methods were introduced in 2001. The "McDonald Criteria" have been extensively assessed and used since 2001. New evidence and consensus now strengthen the role of these criteria in the multiple sclerosis diagnostic workup to demonstrate dissemination of lesions in time, to clarify the use of spinal cord lesions, and to simplify diagnosis of primary progressive disease. The 2005 Revisions to the McDonald Diagnostic Criteria for MS should simplify and speed diagnosis, whereas maintaining adequate sensitivity and specificity. more

Topics: McDonald criteria (79%), Poser criteria (70%), Multiple sclerosis functional composite (56%) more

4,686 Citations

Journal ArticleDOI: 10.1002/ANA.20009
William E. Klunk1, Henry Engler2, Agneta Nordberg3, Yanming Wang1  +17 moreInstitutions (3)
Abstract: This report describes the first human study of a novel amyloid-imaging positron emission tomography (PET) tracer, termed Pittsburgh Compound-B (PIB), in 16 patients with diagnosed mild AD and 9 controls. Compared with controls, AD patients typically showed marked retention of PIB in areas of association cortex known to contain large amounts of amyloid deposits in AD. In the AD patient group, PIB retention was increased most prominently in frontal cortex (1.94-fold, p = 0.0001). Large increases also were observed in parietal (1.71-fold, p = 0.0002), temporal (1.52-fold, p = 0.002), and occipital (1.54-fold, p = 0.002) cortex and the striatum (1.76-fold, p = 0.0001). PIB retention was equivalent in AD patients and controls in areas known to be relatively unaffected by amyloid deposition (such as subcortical white matter, pons, and cerebellum). Studies in three young (21 years) and six older healthy controls (69.5 +/- 11 years) showed low PIB retention in cortical areas and no significant group differences between young and older controls. In cortical areas, PIB retention correlated inversely with cerebral glucose metabolism determined with 18F-fluorodeoxyglucose. This relationship was most robust in the parietal cortex (r = -0.72; p = 0.0001). The results suggest that PET imaging with the novel tracer, PIB, can provide quantitative information on amyloid deposits in living subjects. more

Topics: Alzheimer's disease biomarkers (53%), Pittsburgh compound B (53%), Cortex (anatomy) (51%) more

3,818 Citations

No. of papers from the Journal in previous years

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Journal's top 5 most impactful authors

Stephen L. Hauser

113 papers, 4.4K citations

S. Claiborne Johnston

64 papers, 966 citations

Samuel F. Berkovic

47 papers, 5.1K citations

Anthony E. Lang

45 papers, 7.2K citations

David R. Cornblath

28 papers, 6.6K citations

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