Showing papers in "Annals of Oncology in 2007"

TL;DR: Pooled prevalence of pain was >50% in all cancer types with the highest prevalence in head/neck cancer patients (70%; 95% CI 51% to 88%).

TL;DR: An expert Panel reaffirmed the primary importance of determining endocrine responsiveness of the cancer as a first approach to selecting systemic therapy and recommended the use of high-quality standard histopathological assessment for both risk allocation and target identification.

TL;DR: The European Guidelines for Quality Assurance in Breast Cancer Screening and Diagnosis (EQAQD) as mentioned in this paper have been developed as a global standard for quality assurance in breast cancer screening and diagnosis.

TL;DR: Four platinum-based combination regimens against cisplatin plus irinotecan have similar efficacy and different toxicity profiles, and they can be used to treat advanced NSCLC patients.

TL;DR: The current knowledge on the preclinical and clinical evidence about the mechanism of action of trastuzumab and on the mechanisms underlying the development of resistance are summarized and their possible clinical implications are discussed.

TL;DR: Histological tumor regression was most common among oxaliplatin-treated patients and associated with better clinical outcome, and should be considered when evaluating efficacy of chemotherapy for HCRM.

TL;DR: A third international panel of representatives of a number of breast cancer clinical research groups was convened in September 2006 to update recommendations regarding neoadjuvant treatment for operable disease, and indications for neoadJuvant treatment were newly defined.

TL;DR: The second international cognitive workshop was held in Venice in October 2006 and established an international task force to provide guidelines for future research and information on how best to manage cognitive impairment after cancer treatment.

TL;DR: A median survival of 23 months for patients undergoing EPP compares favourably with the survival reported from single center studies of upfront surgery, and the observed rate of operability is promising.

TL;DR: The results of the study indicate that ERCC1 may predict survival in bladder cancer treated by platinum-based therapy.

TL;DR: Angiosarcomas have an overall poor outcome, but with a clearly distinct prognosis depending on the primary site, and PS, liver and soft tissue tumors were identified as independent prognostic factors for progression-free survival.

TL;DR: It is concluded that GM-CSF may increase the vaccine-induced immune response when administered repeatedly at relatively low doses whereas an opposite effect was often reported at dosages of 100-500 microg.

TL;DR: Genexol-PM plus cisplatin combination chemotherapy showed significant antitumor activity and the use of CrEL-free, polymeric micelle formulation of pac litaxel allowed administration of higher doses of paclitaxel compared with the Cr EL-based formulation without significant increased toxicity.

TL;DR: The identified independent prognostic factors for survival were cancer type, liver metastases and serum albumin, which should be used to select patients for multimodality therapy for adequate palliation.

TL;DR: The combination of cetuximab and FOLFIRI is active in gastric and GEJ adenocarcinoma, and the higher toxicity appears to be limited to neutropenia.

TL;DR: A systematic review evaluated the current evidence for CRS and PIC for DMPM, which demonstrated an improved overall survival, as compared to historical controls, using systemic chemotherapy and palliative surgery.

TL;DR: CRC patients with high EGFR gene copy number have an increased likelihood to respond to cetuximab therapy, and Prospective clinical trials with a careful standardization of assay conditions and pattern interpretation are urgently needed.

TL;DR: It was found that the more intensive and health professional based therapies generally yielded the greater volume reductions, whilst self instigated therapies such as compression garment wear, exercises and limb elevation yielded smaller reductions.

TL;DR: Increased risks from lung and bladder cancers were found in PAH-related occupations, apart from those for coal gasification, and whether they were due at least partially to some bias or confounding remains open to discussion.

TL;DR: In this paper, the authors quantitatively identified 18 important domains that contribute to a good death in Japanese cancer care, including "physical and psychological comfort", "dying in a favorite place", "good relationship with medical staff", "maintaining hope and pleasure", "not being a burden to others", "relationship with family, good relationship with family" and "environmental comfort".

TL;DR: Autoantibody assays against a panel of antigens could be used as an aid to mammography in the detection and diagnosis of early primary breast cancer, especially in younger women at increased risk of breast cancer where mammography is known to have reduced sensitivity and specificity.

TL;DR: The identification of the ethnic group of families undergoing genetic counseling enables the geneticist and oncologist to make more specific choices, leading to simplify the clinical approach to genetic testing carried out on members of high-risk families.

TL;DR: An international expert panel reviewed and discussed the evidence available from clinical trials regarding diagnostic, therapeutic and supportive measures with emphasis on their impact on the quality of life and overall survival of patients with metastatic breast cancer.

TL;DR: A strong correlation was present between the percentages of deaths from pleural and peritoneal mesothelioma and studies of workers exposed only or predominantly to chrysotile asbestos resulted in a lower proportion of total deaths from peritoneAL mesot Helioma than studies of Workers exposed to amphibole or mixed type of asbestos.

TL;DR: The available data regarding the etiology and potential management strategies of PPE associated with PLD are reviewed to support the roles of drug excretion in sweat and local pressure as contributors.

TL;DR: The incidence of CNS relapse in 1693 patients treated for aggressive lymphomas on DSHNHL protocols from 1990 to 2000 was low, although CNS prophylaxis was administered to <5% of patients, and a general prophYLaxis for all patients is not warranted.

TL;DR: GVD is a well-tolerated, active regimen for relapsed HL with results similar to those reported for more toxic regimens, even in heavily pretreated patients.

TL;DR: MRgFUS may provide a safe and effective noninvasive alternative for the palliation of pain, caused by bone metastases, in patients for whom other treatments are either not effective or not feasible.

TL;DR: This article reviews the current literature on long-term complications of venous port systems, focusing on infection and thrombosis, and concludes that routine anticoagulation cannot be recommended.

TL;DR: Focal therapy may minimize treatment toxicity without compromising disease control in HIV negative, immunocompetent PIOL patients, and treatment type did not affect relapse pattern, median PFS or OS.