Showing papers in "Antiviral Research in 2007"
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TL;DR: Emodin, an anthraquinone compound derived from genus Rheum and Polygonum, significantly blocked the S protein and ACE2 interaction in a dose-dependent manner and suggested that emodin may be considered as a potential lead therapeutic agent in the treatment of SARS.
354 citations
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TL;DR: The antiviral activity of plant lectins with specificity for different glycan structures against the severe acute respiratory syndrome coronavirus (SARS-CoV) and the feline infectious peritonitis virus (FIPV) in vitro is described.
250 citations
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TL;DR: Results support the use of neuraminidase inhibitors as the most appropriate class of antiviral drug to prevent or treat human A(H5N1) virus infections.
210 citations
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TL;DR: It is suggested that RNAi is capable of silencing sequence-specific genes of WSSV and might constitute a new therapeutic strategy for W SSV infection in shrimp.
204 citations
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TL;DR: It is demonstrated that wogonin possesses potent anti-HBV activity both in vitro and in vivo, and is under early development as an anti- HBV drug candidate.
160 citations
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TL;DR: It is established that the inhibition of HBV genome replication by a non-nucleoside analogue acting at the level of viral encapsidation and packaging is a potentially useful strategy for future therapeutic drug development in the management of chronic hepatitis B.
140 citations
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TL;DR: From HPMPA originated three compounds, which have been approved by regulatory agencies worldwide for clinical use and were found to exhibit an antiviral activity spectrum and potency comparable to that of the parent compounds HPMPC, PMEA and PMPA, respectively.
137 citations
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TL;DR: It is demonstrated that a polyphenol rich extract from the Mediterranean plant Cistus incanus exerts a potent anti-influenza virus activity in A549 or MDCK cell cultures infected with prototype avian and human influenza strains of different subtypes.
137 citations
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TL;DR: In mice infected with the lung-adapted PR-8 virus, inhalation and nasal inoculation of CA significantly increased survival rates on the 8 days to 100% and 70%, respectively, in contrast to a survival rate of 20% in the untreated control group.
125 citations
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TL;DR: CYSTUS052, a plant extract from a special variety of Cistus incanus that is rich in polymeric polyphenols, exhibits antiviral activity against a highly pathogenic avian influenza A virus (H7N7) in cell culture and in a mouse infection model.
112 citations
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TL;DR: A cell-based screen for potential influenza antivirals that measures the cytopathic effect (CPE) induced by influenza virus (A/Udorn/72, H3N2) infection in Madin Darby canine kidney (MDCK) cells using the luminescent-based CellTiter Glo system is developed.
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TL;DR: It is concluded that construction optimization could dramatically increase the H5 HA gene DNA vaccine efficacy in chickens, and therefore, greatly decrease the dose necessary for inducing complete protection in chickens.
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TL;DR: To find naturally chemical entities as lead compounds from which novel anti-HCV agents could be developed, bioassay-guided fractionation and isolation were performed on a crude ethanol extract from rhizomes of the Chinese medicinal herb Rhodiola kirilowii (Regel) Maxim using column chromatography techniques and in vitro inhibitory activity against HCV NS3-SP.
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TL;DR: It is provided the first evidence that PA, a novel anti-HBV substance derived from traditional Chinese herb S. miltiorrhiza, can efficiently inhibits HBV replication in HepG2 2.2.15 cell line in vitro and inhibit DHBv replication in ducks in vivo.
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TL;DR: It is demonstrated that YHV-protease dsRNA gives therapeutic effect and pave the way to develop a cure for YhV-infected shrimps.
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TL;DR: The anti-HSV compound from P. vulgaris is a lignin-polysaccharide complex with potent activity against HSV-1 and HSV -2 and appears to be inhibiting viral binding and penetration into host cells.
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TL;DR: It is shown that several siRNAs specific for conserved regions of influenza virus matrix (M2) and nucleocapsid protein (NP) genes could effectively inhibit expression of the corresponding viral protein.
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TL;DR: The construction of subgenomic EGFP- or Renilla luciferase-reporter based dengue replicons of the type 2 New Guinea C (NGC) strain and the establishment of stable BHK21 cell lines harboring the replicons are described.
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TL;DR: In vitro model study showed that probiotic bacteria, either from the species Lactobacillus or Bifidobacteria have the ability to decrease viral infection by establishing the antiviral state in macrophages, by production of NO and inflammatory cytokines such as interleukin 6 and interferon-gamma.
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TL;DR: This system provides the first convenient in vitro assay for exploiting p7 as a therapeutic target and demonstrates that activity is due to the formation of a size-selective pore rather than non-specific disruption of liposomes and that activity can be blocked by amantadine and several other compounds.
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TL;DR: T-705 was found to be more active than ribavirin in cell-based assays and in vivo, as reflected by substantially greater therapeutic indexes, and suggest that T-705 may be a viable alternative for the treatment of life-threatening bunyaviral and arenaviral infections.
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TL;DR: Quantitative characterization of the HSV-1 infection in the presence of octyl gallate revealed that this reagent can directly inactivate HSV (virucidal activity), it suppresses both the intracellar multiplication and the release of the virus, and the addition of the reagent even at 6-h post infection completely abolished the formation of progeny virus in the infected cells.
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TL;DR: It is indicated that TLR7/8 agonists may have prophylactic and therapeutic benefits in the treatment of respiratory viral infections, such as influenza, when administered prior to or shortly after viral inoculation.
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TL;DR: Results collectively indicate that SRS represents a novel candidate for anti-HIV-1/HSV microbicide development and blocked viral entry and virus-cell fusion likely through interacting with the HIV-1 envelope glycoprotein.
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TL;DR: SeqHepB will enable virologists and physicians to individualise patient management, cope with the explosion of antiviral associated HBV mutations, and to conduct cross-sectional retrospective or prospective studies on HBV-infected individuals during therapy.
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TL;DR: It is proved that GFAHP directly inactivates HSV-1 while simultaneously inhibiting HSV -1 penetration into Vero cells and characterizes an anti-HSV protein from G. frondosa.
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TL;DR: The data show for the first time that an active alpha-glucosidase activity is crucial for production of infectious HBV and provide new insights into the controversial role of the M protein in this process.
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TL;DR: This is the first time that lactoferrin was demonstrated to have an inhibitory effect on HPV infection and the antiviral activity differed depending on size, charge and structures of the lactoferricin.
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TL;DR: Small interference RNAs targeting sgRNA 2, 3 and 7 suggest that the accessory proteins, i.e. 3a and 7a, could play an important role during the replication cycle of the SARS-CoV.
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TL;DR: This study analysed recent human influenza A strains isolated in Australia and regionally for evidence of resistance to adamantanes and found evidence of significant resistant emerging during 2005.