Showing papers in "Archives of Biochemistry and Biophysics in 2007"

TL;DR: The term mitophagy is used to refer to mitochondrial degradation by autophagy, and the possible role of the mitochondrial permeability transition in mitophagic delivery to lysosomes is the major degradative pathway in mitochondrial turnover.

TL;DR: The results provide useful global guidelines for obtaining sufficient vitamin D3 by cutaneous synthesis and from dietary intake to prevent vitamin D deficiency and its health consequences, ensuing illness, especially, bone fractures in the elderly.

TL;DR: Experimental findings showing that magnesium modulates cellular events involved in inflammation suggest that inflammation is the missing link to explain the role of magnesium in many pathological conditions.

TL;DR: An update on the current state of the understanding of the localization and trafficking properties of the copper-ATPases in cells and tissues, the molecular signals and posttranslational interactions that govern their trafficking activities, and the cellular basis for the clinical phenotypes associated with disease-causing mutations are provided.

TL;DR: Benefits of Mg supplementation on metabolic profile in diabetic subjects have been found in most, but not all clinical studies, and larger prospective studies are needed to support the potential role of dietary Mg supplements as a possible public health strategy in diabetes risk.

TL;DR: The results suggest that cinnamon exhibits the potential to increase the amount of proteins involved in insulin signaling, glucose transport, and anti-inflammatory/anti-angiogenesis response.

TL;DR: The human AKRs are highly polymorphic, and in some instances single nucleotide polymorphisms (SNPs) of high penetrance exist, which suggests that there will be inter-individual variation in endogenous and xenobiotic metabolism which in turn affect susceptibility to nuclear receptor signaling and chemical carcinogenesis.

TL;DR: The relationship between this morphological change and intracellular monovalent ions during apoptosis is examined, suggesting multiple ways exist to accomplish the same goal of AVD.

TL;DR: At the center of zinc/redox signaling are the zinc/thiolate clusters of metallothionein, which can transduce zinc and redox signals and thereby attenuate or amplify these signals.

TL;DR: This review focuses on the recent advances in understanding the mechanisms whereby MTF-1 regulates MT gene expression to protect the cell from fluctuations in environmental zinc, and particular emphasis is devoted to recent studies involving the Cys2His2 zinc finger DNA-binding domain.

TL;DR: A positive, significant correlation between serum 25(OH)D concentration and MMSE in these patients suggests a potential role for vitamin D in cognitive function of older adults.

TL;DR: This review will attempt to elucidate the mechanisms involved in hormonal-mediated Mg(2+) extrusion and accumulation, as well as the physiological implications of changes in cellular Mg (2+) content following hormonal stimuli.

TL;DR: Key steps in the biosynthesis of strawberry flavonoid end products are elucidate by means of in vitro assays, with special emphasis on specificity for the biologically relevant 4'- and 3',4'-hydroxylated compounds.

TL;DR: Zinc accumulation in prostate cells is regarded as a tumor suppressor gene in prostate cancer because of the expression and activity of the zinc uptake transporter, ZIP1, which exhibits anti-proliferative effects via its induction of mitochondrial apoptogenesis.

TL;DR: The present review discusses the current understanding of PLSCR1 in relation to its trafficking, localization and signaling functions.

TL;DR: The present state of knowledge about the molecular mechanisms of AhR-mediated CYP1 induction is summarized, and recent advances in the study of the physiological functions of Ahr are focused on.

TL;DR: The regulation of the lysosomal content of redox-active iron seems to be essential for the survival of cells both in the short- and the long-term.

TL;DR: The role of magnesium in the regulation of vascular function and blood pressure is addressed, the implications of magnesium deficiency in experimental and clinical hypertension, in metabolic syndrome and in pre-eclampsia are discussed and the therapeutic value is unclear.

TL;DR: It is concluded that plasma membrane permeabilization is the principal cause of necrotic transformation in nsPEF-exposed cells and probably contributes to other known ns PEF bioeffects.

TL;DR: Compiling the recently available structural data on both enzymes with available mechanistic data as well as current NMR data on flavin systems supports the proposal that a polar nucleophilic mechanism for amine oxidation is the most consistent mechanistic scheme as compared with the single electron transfer mechanism.

TL;DR: The interrelations between autophagy and apoptosis under these conditions is discussed, showing that stress is a positive regulator of apoptosis and, in particular, of its apoptosome-mediated mitochondrial pathway.

TL;DR: The order of reactivities between PRDX5 towards oxidizing substrates differ from other PRDXs studied, pointing to a selective action ofPRDXs with respect to peroxide detoxification, helping to rationalize the multiple enzyme isoforms present even in the same cellular compartment.

TL;DR: The results demonstrate that SARS-CoV PLpro can differentiate between ubiquitin-like modifiers sharing a common C-terminal sequence, and that the debranching activity of the PLpro is linkage type selective.

TL;DR: It is suggested that the reactivity of apocynin radical with thiol compounds could be involved in the inhibitory effect of this methoxy-catechol on NADPH oxidase complex.

TL;DR: The identification and description of the first terpene synthases from L. angustifolia forms the basis for the biotechnological modification of essential oil composition in lavender.

TL;DR: Both pharmacological inhibition with DPI and genetic studies using p47(phox) knockout mice provided evidence for a central role of NADPH oxidase in the regulation of HSC-activity and liver fibrosis.

TL;DR: The cytotoxicity of 23 different flavonoids, including O-methylated and glucuronidated metabolites, on the human leukemia cell line Jurkat E6-1 is determined by analyzing cell death triggered after 24 and 48 h and several structure-function relationships associated with enhanced cytotoxic activity are identified.

TL;DR: Recent epidemiological studies in community-dwelling older adults show that low serum/plasma carotenoids are independently associated with low skeletal muscle strength and the development of walking disability, consistent with a growing number of studies showing that a diet with high intake of fruits and vegetables is associated with a reduced risk of inflammation, hypertension, diabetes, cardiovascular disease, and mortality.

TL;DR: Current information on structural features and functional properties of ATP7A and ATP7B are summarized and sequence motifs unique for each Cu-ATPase are described and speculated about their role in regulating ATP7 a and ATP 7B activity and trafficking.

TL;DR: The results show that Trx 2 interacts with Prx3 in vivo and that the Trx2/Prx3 system functions in parallel with the GSH system to protect mitochondria from oxidative stress.