Showing papers in "Archives of Biochemistry and Biophysics in 2019"

TL;DR: A thorough overview of both inflammasome-dependent and -independent NLR signaling will be presented, with highlights from the field as well as promising future directions and postulates based on the known science.

TL;DR: The evidence that directly connects mitochondrial dysfunction and aberrant mitochondrial signaling with skeletal muscle atrophy is highlighted and the mechanisms linking these interconnected phenomena are discussed.

TL;DR: A crucial area of investigation focuses on understanding the role of NOD1 and NOD2 at the intestinal mucosa, as this is of prime importance for understanding the etiology of Crohn's disease.

TL;DR: Lysosomal cysteine cathepsins are members of a diverse and complementary family, and likely share both overlapping and independent functions in NLRP3 inflammasome activation.

TL;DR: This review reviews the fundamental parameters and approaches to work at the limit of AFM resolution in order to perform single molecule statistical analysis of biomolecules and nanoscale protein aggregates and examines the structural properties of amyloid-inspired functional nanomaterials.

TL;DR: In this review, a series of diverse strategies have been implemented that focus on increasing HO-1 and HO activity that are central to reversing the clinical complications associated with diseases including, obesity, metabolic syndrome and vascular disease are examined.

TL;DR: The analysis of the molecular mechanism of STAT1 signaling reveals that hypoxia generates oxidative stress and induces both phosphorylation and S-glutathionylation ofSTAT1 that are responsible of its aberrant activation.

TL;DR: Insight is offered into the connections between molecular and cellular control of GCK and its essential role in maintaining whole-body glucose homeostasis.

TL;DR: Findings indicated that circZFR may exert carcinogenic role in HCC through regulating miR-3619-5p/CTNNB1 axis and activating Wnt/β-catenin pathway and may provide a novel perspective for the treatment of hepatocellular carcinoma.

TL;DR: The interplay between mitochondrial autophagy, mitochondrial dysfunction, and the regulation and resolution of inflammation may make important contributions to the protection afforded by HO-1/CO in cellular and organ injury models.

TL;DR: CASC15 silencing overcame OXA resistance of CRC by regulating miR-145/ABCC1 axis, providing a potential therapeutic target for CRC chemoresistance.

TL;DR: The already available drugs and products, that target the diverse pathways of the NLRP3 - IL-1β axis, and the future therapeutic perspectives are discussed.

TL;DR: It is demonstrated that propionate at a physiologically-relevant concentration effectively suppresses palmitate-enhanced glucose production in HepG2 cells but does not affect intracellular neutral lipid levels.

TL;DR: The recent progress in determining the roles of proton leak in regulating mtROS is reported, and several important findings are highlighted.

TL;DR: This manuscript thoroughly reviews three areas of peptide vector research of particular interest to us, namely (i) efficient transport of low-bioavailability drugs into the brain; (ii) CPP-delivered disruptors of G protein-coupled receptor (GPCRs) heteromers related to several disorders, and (iii) C PP-mediated delivery of useful but poorly internalized drugs into parasites.

TL;DR: MEG3 overexpression inhibited the tumorigenesis of breast cancer by downregulating miR-21 through the PI3K/Akt pathway.

TL;DR: An overview of the APP response to viral infections is presented reviewing the current knowledge in the field and investigating the role of acute phase response proteins as immunoregulatory molecules and their potential as therapeutic reagents.

TL;DR: Purified recombinant PRMT7 displays a number of unique enzymatic properties including a substrate preference for arginine residues in R-X-R motifs with additional flanking basic amino acid residues and a temperature optimum well below 37 °C.

TL;DR: Overall, the potential of Baicalein in dissolving the preformed Tau oligomers as well as mature fibrils can be of utmost importance in therapeutics for Alzheimer's disease.

TL;DR: It is suggested that ACE2 could alleviate the severity of ALI, inflammation and autophagy in lung tissue through the AMPK/mTOR pathway.

TL;DR: The overall studies have concluded that Brahmi can be used as a lead formulation for treatment of Alzheimer's disease and other neurological disorders and the inhibitory role of Brahmi against Tau-mediated toxicity is hypothesized.

TL;DR: The study revealed that TEL, particularly at 7 mg/kg, alleviated tissue injury and inflammatory signs upon histological analysis and enhanced survival and recovery during DSS-induced colitis, and concluded that PPARγ and CD36 might play a critical role in the pathogenesis of murine colitis and that further investigations on human IBDs are warranted.

TL;DR: A reaction mechanism in which the heterocycle of the compatible solute ectoine is cleaved and further oxidized at the C-terminus will help to explain observed effects as anti-inflammatory compound in skin, lung and bowel disease.

TL;DR: This review details the most common experimental approaches to assess and characterize protein intrinsic structural disorder, with the notable exception of NMR and EPR spectroscopy, and discusses the currently available methods to model IDPs as conformational ensembles.

TL;DR: It is demonstrated that fusion of macrophages promotes proliferation, migration and invasion of breast cancer cells through activating EMT and Wnt/β-catenin signaling pathway.

TL;DR: This review describes the current knowledge on the biophysical aspects of inflammasome formation from the perspective of ASC and elaborates on the identification of ASC interacting surfaces at the amino acid level using NMR techniques.

TL;DR: This review focuses specifically on Ca2+ signaling between SR and mitochondria in adult cardiomyocytes, and discusses the physiological and pathological implications of this SR-mitochondrial Ca 2+ signaling, research gaps, and future trends.

TL;DR: The present study revealed that the APT-DOX-PLGA-PVP NPs improved the therapeutic efficiency through the nucleolin receptor endocytosis targeted drug release as evident by mice weight and tumor size followed by the histopathological study.

TL;DR: It is suggested that photon-induced ROS is sufficient to cause depolarization events of individual mitochondria in quiescent cells; without electrical or mechanical activity to stimulates mitochondrial metabolism, and without raising the mitochondrial matrix Ca2+.

TL;DR: The present review discusses the important functional roles of PTMs crosstalk in proteins associated with cancer diseases and insight into the complexity of PT Ms crosStalk will help to better understand etiology and provide novel targets for drug therapy.