Showing papers in "Archives of Biochemistry and Biophysics in 2021"

TL;DR: The role of the mitochondria in the development and progression of neurodegenerative diseases is summarized and current therapeutic approaches that target mitochondrial dysfunction in these diseases are presented.

TL;DR: In this article, the proper method for malondialdehyde (MDA) determination using HPLC was discussed and reference MDA values in humans in physiological and pathological conditions.

TL;DR: It is demonstrated that Kaempferol is a potent inhibitor of Nrf2 and can be used as a natural sensitizer and anti-cancer agent for lung cancer therapeutics.

TL;DR: This comprehensive review looks at the most important aspects of hSOD1, including the structure, properties, and characteristics as well as transcriptional, translational and post-translational modifications that the enzyme can receive and their effects, and its many functions.

TL;DR: In this paper, the inhibitory effect of morroniside on inflammatory and oxidative stress activated by lipopolysaccharide (LPS) in RAW 264.7 macrophages was investigated.

TL;DR: In this article, the effects of Luteolin on liver biochemical parameters, intestinal histopathology and integrity, gut microbiota, lipopolysaccharides (LPS), inflammatory cytokines, and the Toll-like receptor 4 (TLR4) signaling pathway were evaluated.

TL;DR: In this paper, the structural and mechanistic characteristics of distinct types of flavoprotein monooxygenases (FPMOs) are highlighted, which enables reactions such as (aromatic) hydroxylation, epoxidation, (de)halogenation, heteroatom oxygenation, Baeyer-Villiger oxidation, or non-oxidative carbon-hetero bond cleavage.

TL;DR: Coptisine-mediated autophagic cell death was regulated by PI3K/Akt/mTOR signaling and mitochondrial ROS production associated with mitochondrial dysfunction and these findings suggest that coptisine exerts its anti-cancer effects through induction of autophagy in HCC Hep3B cells.

TL;DR: In this article, the effect of VD on pyroptosis and gut microbiota in NAFLD remains inconclusive, however, there is some evidence that VD has a therapeutic effect on non-alcoholic fatty liver disease (NAFLD).

TL;DR: The current review briefs the impact of ischemia reperfusion (I/R) pathogenesis in various organs, role of miRNAs in the regulation of Nrf2 and the I/R protective effect of compounds that alter their expression.

TL;DR: In this article, the basics of epithelial to mesenchymal transition during both development and disease conditions and emphasize the role of various transcription factors and miRNAs involved in the process.

TL;DR: In this paper, the role of micro-RNAs in five major chronic pediatric diseases including bronchial asthma, congenital heart diseases, cystic fibrosis, type 1 diabetes mellitus, and epilepsy is discussed.

TL;DR: This work will focus on the advantages that these algorithms provide over the traditional methods in the context of early drug discovery, and can the intrinsic difficulties within the drug discovery process be overcome with the implementation of Artificial Intelligence.

TL;DR: In this paper, the mesenchymal stem cells (MSC) derived exosomes are used as cell-free regenerative reagents for osteoarthritis (OA) treatment.

TL;DR: It is demonstrated that multiple sclerosis has a phospholipidomic signature different from that of healthy controls, especially the PE, PC, LPE, ether- linked PE and ether-linked PC species, and few phospholIPids, with the lowest p-value, may be suitable as biomarkers for clinical applications in multiple sclerosis.

TL;DR: In this paper, the role of lipids in synaptic transmission and how the lipid composition of SVs is affected by dynamic exo-endocytotic cycling is discussed, and the current knowledge about the composition, organization and function of SV membrane lipids is summarized.

TL;DR: In this paper, a review is presented to find, combine, analyze, and represent the multiple oncogenic signaling pathways with their downstream and upstream regulation activated or enhanced by USP8, which will help the researchers to find any therapeutic strategy for drug discovery by inhibiting or suppressing the multi-targeted USP 8.

TL;DR: The present study revealed that the resistant wheat lines were having enough diversity regarding slow rusting behavior and yellow rust resistance, ranging from immunity to partial resistant lines.

TL;DR: Calcitriol ameliorates ethanol-induced hepatocyte damage by enhancing autophagy and may offer a convenient preventive and hepatoprotective mean for people on occasional social drink.

TL;DR: It is found that radiation downregulates miR-155-5p in alveolar epithelial cells that induces EMT, which contributes to RIPF using GSK-3β/NF-κB pathway, which provides further understanding on the regulation of RIPF and identifies potential therapeutic targets.

TL;DR: In this paper, the authors outline the global organization of FBEB enzymes, the functions of the flavins therein and the surrounding of the isoalloxazine rings by which their reduction potentials are specifically adjusted in a finely tuned energy landscape.

TL;DR: In this paper, the authors highlight the main features of FUR proteins that differ from the canonical Fur paralog either in the coregulatory metal, such as Zur, Nur and Mur, or in the action mechanism to control target genes.

TL;DR: In this paper, the authors summarize recent advancements in the flavin-dependent monooxygenase field including aspects of flavin dynamics, formation and stabilization of reactive species, and the hydroxylation mechanism.

TL;DR: Findings indicate that mitochondrial reactive oxygen species is associated with iron-related oxidative reactions and is implicated in the development of some diseases such as neurodegenerative disease, cardiovascular disease, and carcinogenesis.

TL;DR: In this article, the benefits of experimental treatment with AB23A on gut microbiota dysbiosis in NAFLD with an obesity model were investigated, which revealed that AB23a displayed a prebiotic capacity in high-fat diet (HFD)fed mice.

TL;DR: In this article, the effect of microRNA-424 (miR-424) on the process of colorectal cancer (CRC) was identified, where exosomes were obtained from bone marrow mesenchymal stem cells (BMSCs).

TL;DR: Clinical and experimental studies exploring the association between PCSK9, cardiac diseases, and their related risk factors and aiming to identify possible underlying mechanisms are reviewed.

TL;DR: In this paper, suppressors of the site IQ electron leak (S1QEL) and suppressor of site IIIQo electron leak(S3QEL), small molecules that suppress mitochondrial superoxide production from complex I and III, respectively, were employed to protect mouse hepatoma Hepa 1-6 cells from lipid peroxidation and subsequent ferroptosis induced by cysteine starvation (cystine deprivation from culture media or xCT inhibition by erastin).

TL;DR: In this paper, the effects and molecular mechanisms of resveratrol and mesenchymal stem cell (MSC) individual and combined treatment in management of osteoporosis in ovariectomized rats were explored.

TL;DR: It is supported that miR-425 in BMSCs-Exos inhibits HILI by targeting PTEN and upregulating the PI3K/AKT axis.