Showing papers in "Archives of Biochemistry and Biophysics in 2022"

TL;DR: In this article , the role of SET domain bifurcated 1 (SETDB1) in pulmonary fibrosis was investigated and it was found that SETDB1 inhibited EMT and that cells attenuated the expression of SETDB 1 to relieve this inhibition during transforming growth factor-β (TGF-β)-induced EMT.

TL;DR: In this paper, the role of SET domain bifurcated 1 (SETDB1) in pulmonary fibrosis was investigated and it was found that SETDB1 inhibited EMT and that cells attenuated the expression of SETDB 1 to relieve this inhibition during transforming growth factor-β (TGF-β)-induced EMT.

TL;DR: The present study is the first to effectively demonstrate the inhibitory effect of salidroside on DHT‐stimulated oxidative stress and apoptosis in KGN cells, which was dependent on Nrf2 activation that involved AMPK.

TL;DR: In this article, a review of regulatory factors and signaling mechanisms of regulatory death in endothelial cells, discussing their effects in the context of the atherosclerotic procession is presented.

TL;DR: In this paper , a review of regulatory factors and signaling mechanisms of regulatory death in endothelial cells, discussing their effects in the context of the atherosclerotic procession is presented.

TL;DR: In this paper , a photo-induced cyclic peroxidation in isolated chloroplasts is described, where chloroplast upon illumination produces malondialdehyde (MDA)-a decomposition product of tri-unsaturated fatty acid hydroperoxides-bleach endogenous chlorophyll, and consume oxygen.

TL;DR: Wang et al. as mentioned in this paper identified the molecular mechanisms behind curcumin's therapeutic benefits for metabolic syndrome (MetS) and its components, including NOS3, IL6, INS, and ADIPOQ.

TL;DR: In this article , the effect of salidrotestosterone (DHT)-induced granulosa-like tumor cell line (KGN) mediated via antioxidant mechanisms was explored and established.

TL;DR: In this article , the authors found that wide variations in accessory proteins seem to affect the pathogenicity of SARS-CoV-2, and the authors suggested that the wide variations of accessory proteins seemed to affect host immune mechanisms, such as interferons, immune signaling receptor NLRP3 (NLR family pyrin domain-containing 3) inflammasome, and inflammatory cytokines.

TL;DR: In this article , the effects of Mdivi-1 on reactive cardiac fibrosis and cardiac function post myocardial infarction and its potential mechanisms were investigated, and it was found that the effects partially relied on increasing the expression of Hmox1 and inhibiting oxidative stress.

TL;DR: In this paper , a reduced form of ubiquinone appeared to be responsible for the reduction of O2 to O2− and H2O2 during autoxidation of quinols.

TL;DR: FAM98A is a microtubule-associated protein involved in cell proliferation and migration, and is frequently dysregulated in epithelial cancers as discussed by the authors , but its role in the development of colorectal cancer (CRC) remains unknown.

TL;DR: In this article , Wu et al. provided the bioinformatic and biochemical characterization of six α-L-fucosidases that belong to the 29 and 95 families of glycoside hydrolases (GH) from the fucoidan-degrading locus of the marine bacterium Wenyingzhuangia fucanilytica CZ1127T.

TL;DR: In this article , the authors investigated the hepatoprotective effect and the possible underlying molecular mechanisms of naringenin in lipopolysaccharide (LPS)/D-galactosamine (D-Gal) mouse model of acute liver failure.

TL;DR: In this paper , a short review discusses the targets of alpha, β-unsaturated aldehydes, and particularly two prototypic cases, acrolein and dimethylfumarate, and the factors that control the selectivity and kinetics of reaction of these species.

TL;DR: In this article , the authors focused on the biophysical features of PADI4 and, more importantly, how its expression was altered in cancer cells, by using a combination of biophysical techniques and in silico molecular dynamics simulations.

TL;DR: In this paper , the authors simulated support afferentation during hindlimb unloading and investigated its effect on postural soleus muscle functional properties and signaling, and found that support afference under hind limb suspension leads to maintaining a slow-twitch oxidative and fatigue-resistant soleus-muscle fibers phenotype.

TL;DR: In this article , the relationship between iron metabolism and proliferation, metastasis, and ferroptosis of hypoxic cancer cells, as well as several iron-targeted cancer therapy strategies is described.

TL;DR: In this article , the authors determined molecular consequences of interactions between Aβ42 and αS in their respective monomeric, oligomeric and fibrillar forms using a comprehensive set of experimental tools.

TL;DR: In this paper , it was shown by NMR that both peptides are unstructured in solution but get structured in the presence of DPC micelles, mimicking the surface of biological membranes.

TL;DR: In this article, it was shown by NMR that both peptides are unstructured in solution but get structured in the presence of DPC micelles, mimicking the surface of biological membranes.

TL;DR: In this paper , the authors investigated whether ECG prevented high altitude cerebral edema by inhibiting hyperactivated microglia, which is associated with exposure to altitude-related hypobaric hypoxia.

TL;DR: In this paper , the authors analyzed the varying effects of both intra and inter-molecular disulfide bonds on the amyloid aggregation propensities of a few proteins associated with a few disorders, including Parkinson's disease, Type II diabetes, Amyotrophic Lateral Sclerosis (ALS), and prion diseases.

TL;DR: In this paper , a meta-analysis of four transcriptome datasets was performed to identify gene expression signatures in PTC, and reporter molecules were determined by mapping gene expression data onto three major cellular networks, i.e., transcriptional regulatory, protein-protein interaction, and metabolic networks.

TL;DR: In this article , the authors used linear discriminant analysis (LDA) effect size (LEfSe) to detect the differential microbiotas between the two groups and further validated the results by correlation analysis with differential metabolites.

TL;DR: In this article , the 3D structures and properties of fungal LOX are compared and contrasted along with their associations with pathogenicity, and a review of 3D structure and properties is presented.

TL;DR: Selenocysteine (Sec), the 21st genetically encoded amino acid, is structurally similar to Cys, but with a sulfur to selenium replacement as discussed by the authors .

TL;DR: In this paper , the role of the distal Ω-loop segments comprising residues 71-85 in human Cytochrome c (hCytc) was investigated by the combination of experimental characterizations and molecular dynamics simulations.

TL;DR: In this paper , the role of exosomes derived from M2-polarized macrophages (M2-Exo) in ischemic stroke has not yet been reported.

TL;DR: In this article , a bioinformatics analysis was performed to evaluate the prognostic value of estrogen receptor 1 (ESR1) in breast cancer tissues and showed that ESR1 knockdown significantly enhanced IR-induced ferroptosis and increased the CD71 protein level.