Asian Journal of Applied Sciences 

About: Asian Journal of Applied Sciences is an academic journal. The journal publishes majorly in the area(s): Population & Germination. It has an ISSN identifier of 2321-0893. It is also open access. Over the lifetime, 1269 publications have been published receiving 4170 citations.

Effects of Zinc Supplementation in Neonatal Hypothyroidism and Cerebellar Distortion Induced by Maternal Carbimazole

Abstract: The aim of this study is to investigate the protective role of Zn on thyroid function and cerebellum impairments induced by carbimazole (CMI) in neonats at PND 28. Animals were divided into four groups: group I acts as control; group II received carbimazole (1.35mg/kg.b.w CMI) only; group III received Zn as zinc sulphate (3mg/kg.b.w) and group IV received Zn and CMI. The administration of maternal CMI caused significant decrease in serum T4, T3 and growth hormone (GH) levels and significant increase in serum TSH levels in both dams and their newborns relative to control group. While in Zinc-hypothyroid group, a reverse pattern was noticed for all previous parameters comparing with hypothyroid group. Maternal CMI administration caused significant decrease in GSH, SOD, GPX, CAT and t-SH of cerebellum and increased prooxidant levels including MDA, H 2 O 2 and NO while Zn administration to hypothyroid dams reversed this effect. CMI administration caused some degeneration and deformation in newborns cerebellum while zinc supplementation to CMI group enhanced structure, length, number and size of purkinje cells, also increase size of the granular layer. Our results indicated that zinc has an improvement role on THs levels and histoarchiture of cerebellum due to its antioxidant role. Key words: Carbimazole, zinc, thyroid hormones, antioxidant, prooxidant