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JournalISSN: 0974-2441

Asian Journal of Pharmaceutical and Clinical Research 

Innovare Academic Sciences
About: Asian Journal of Pharmaceutical and Clinical Research is an academic journal published by Innovare Academic Sciences. The journal publishes majorly in the area(s): Medicine & Phytochemical. It has an ISSN identifier of 0974-2441. It is also open access. Over the lifetime, 5501 publications have been published receiving 21201 citations.


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Journal Article
TL;DR: Recent research progress in development of pectin based formulations (polymer hydrogels, films, tablets, microspheres, nanoparticles and scaffolds) and their biomedical applications are reviewed.
Abstract: Pectin is known as a miracle polymer of natural origin because of its excellent biodegradable and biocompatible nature. Pectin is commercially extracted from different citrus products like apple, pomace, and oranges under mildly acidic conditions. Pectin has been mainly divided in to major group’s namely high methoxyl pectin and low methoxyl pectin. Pectin is a high value functional food ingredient which is widely used as a gelling agent and stabilizer in food industries. Pectin has been widely investigated for targeted drug delivery and other potential biomedical applications. Pectin is known to be rapidly degraded by colonic microorganisms and thus makes it a potential carrier for colon targeted drug delivery. Pectin based formulations have shown tremendous promise as novel biomaterials for development of implantable and prosthetic devices. This paper reviews the recent research progress in development of pectin based formulations (polymer hydrogels, films, tablets, microspheres, nanoparticles and scaffolds) and their biomedical applications.

111 citations

Journal ArticleDOI
TL;DR: In this article, the authors provide an outlook of the various available methods of antioxidant activity, including 1,1-diphenyl-2-picrylhydrazyl method, lipid peroxidation, and an ethanol was used as a solvent for extraction purpose.
Abstract: To provide an outlook of the various available methods of antioxidant activity. Various available in vitro and in vivo methods are listed and the procedure to perform the method, its mechanism is also explained in brief. 1,1-diphenyl-2-picrylhydrazyl method was found to be used mostly for the in vitro antioxidant activity evaluation purpose while lipid peroxidation was found as mostly used in vivo antioxidant assay. An ethanol was with the highest frequency as a solvent for extraction purpose. Summarized information on the various methods available provides with reliable information to confirm the benefits of antioxidant effects. Keywords: Antioxidant activity, Reactive oxygen species, Free radical, 1,1-diphenyl-2-picrylhydrazyl, Flavonoid.

81 citations

Journal ArticleDOI
TL;DR: From the recently published literature, it is clear that the role of BTX as a therapeutic agent for several conditions is expanding and the ability to use Botox as an adjuvant and primary mode of the treatment for various maxillofacial disorders offer sexciting treatment options for dentists and patients in the future.
Abstract: Botulinum toxin (BTX) is a lethal neurotoxin produced by Gram-positive anaerobic bacterium called Clostridium botulinum . It is the first toxin used fortherapeutic purposes since 1989. BTX treatment is relatively safe and efficacious, less invasive, conservative, and the effects are faster and reversible.The purpose of this article is to review the literature regarding the applications of BTX in the treatment of various orofacial disorders, their mechanismof action, contraindications, and complications. From the recently published literature, it is clear that the role of BTX as a therapeutic agent for severalconditions is expanding. With the training of BTX-A injection techniques and adequate knowledge about treatment protocols, general dentists cansafely administer BTX injections. The ability to use Botox as an adjuvant and primary mode of the treatment for various maxillofacial disorders offersexciting treatment options for dentists and patients in the future.

70 citations

Journal Article
TL;DR: The results of the present study demonstrate that the Pseudomonas gessardii is ideal for extracellular lipase production at industrial level.
Abstract: Lipases are glycerol ester hydrolases that catalyze the hydrolysis of triglycerides to free fatty acids and glycerol. Bacterial Lipase producers were isolated from oil spilled soil from vegetable oil processing factories. One of the twenty  isolated strain exhibited a greater zone of clearance than the others indicating higher lipase activity was selected and identified based on their morphological and physicochemical characteristics and 16s rRNA sequencing. The effect of incubation time, medium pH, temperature, agitation, inoculums concentration, carbon source and nitrogen source for the lipase production was studied. The lipase production was maximum at pH7, temperature 370C and incubation time 48 hours by the lipase producing bacteria BLP2                Pseudomonas gessardii. Increased enzymatic production was obtained when the organisms were cultured in medium supplemented with 1% protease peptone by Pseudomonas gessardii (168.7Uml-1). The results of the present study demonstrate that the Pseudomonas gessardii is ideal for extracellular lipase production at industrial level.

63 citations

Journal ArticleDOI
TL;DR: The majority of dental students in this study have good level of knowledge and awareness regarding BMW management in dental clinics, but their practice toward BMW disposal was poor, implying that proper training, continuing education programs, and short-term courses about BMW management, and infection control procedures are required to motivate the dental students and dental auxiliaries.
Abstract: Objective: The objective of this study was to assess the knowledge, awareness, and practices of dental students regarding biomedical waste (BMW)management.Methods: A self-administered structured questionnaire consisting of 16 questions on knowledge, awareness, and practices about BMW managementwas distributed among 100 students randomly belonging to 3rd year, final year and intern students of Saveetha Dental College, Saveetha University,Chennai. The data extracted were tabulated, statistically analyzed using SPSS version 20.0 and results obtained. The data were analyzed using ANOVAtest (all the results are calculated at 1% level of significance) and Post-hoc test.Results: Overall, 67% respondents were aware of the existing BMW management policy systems in India. 62% of students were aware about thecorrect color coding management system for hospital waste management that prevails in India. 86% of students knew about the dental wastecategories of materials used in dentistry. There was a statistically significant difference of knowledge levels among the 3rd year, final year students andthe interns. 100% practice discarding sharps in the puncture-proof containers. Only 27% of the respondents discarded the extracted tooth in a properway. Only 51% of them have attended previous training programs on dental waste management. There was also a statistically significant difference ofBMW disposal practices among the three groups.Conclusion: The majority of dental students in our study have good level of knowledge and awareness regarding BMW management in dental clinics.However, their practice toward BMW disposal was poor. Hence, the knowledge acquired must be put into practice. Intern students have the highestlevel of knowledge and practices toward dental waste disposal when compared to final year and 3rd year students. Hence, these findings imply thatproper training, continuing education programs, and short-term courses about BMW management, and infection control procedures are requiredto motivate the dental students and dental auxiliaries. The importance of training regarding BMW management must be emphasized as the lack ofproper and complete knowledge about BMW management impacts practices of appropriate waste disposal.

59 citations

Performance
Metrics
No. of papers from the Journal in previous years
YearPapers
2023252
2022429
202180
2020105
2019659
20181,177