Showing papers in "Asian Journal of Pharmaceutical Sciences in 2016"

TL;DR: It was concluded that the particle size of the nanoparticles could be reduced further and the paclitaxel release kinetics could easily be adjusted by taking advantage by the inclusion of a co-surfactant.

TL;DR: The aim of this review is to provide an overview of the critical factors affecting the formulation of thin films, including the physico-chemical properties of polymers and drugs, anatomical and physiological constraints, as well as the characterization methods and quality specifications to circumvent the difficulties associated with formulation design.

TL;DR: An overview of PEGylation involving proteins, enzymes, low molecular weight drugs, liposomes and nanoparticles that has been developed, clinically tried for anti-cancer therapy during the last decade is discussed.

TL;DR: This review summarizes the current state-of-the-art in the development of inorganic nanocomposites for photothermal cancer therapy and should provide improved understanding of cancer treatment with photothermal nanomaterials.

TL;DR: The typical in situ gelling systems based on chitosan and mechanisms involved in hydrogel forming are reviewed, and advances of chitOSan-based in situGelling systems for the applications in drug delivery and tissue regeneration are reported.

TL;DR: This review article highlights the in vivo works of GRDDS carried out in the recent past, including their limitations and challenges that need to be overcome in the near future.

TL;DR: This review gives a brief overview about the significant progresses and challenges of certain external-stimuli responsive systems that have been extensively investigated in drug delivery and theranostics within the last few years.

TL;DR: In this article, a review article deals with various aspects of the extrusion-spheronization technique, including different steps in the production process of pellets such as granulation, extrusion, spheronisation, and drying.

TL;DR: PTX/CCM Alb-NPs appear to be efficiently internalized into Mia Paca-2 cells and exhibited a 71% increased IC50 versus PTX Alb-nPs in terms of cytotoxicity to Mia Pacas 2 cells, suggesting that PTX/ CCM Alb -NPs are a new potential anticancer agent for combination therapy.

TL;DR: In this article, the effects of β-cyclodextrin (βCD) and hydroxypropyl-β-cyclodextrin (HPβCD), combined with solvent evaporation, were investigated to investigate the solubility and dissolution rate of norfloxacin.

TL;DR: In this paper, a simple method to fabricate itraconazole (ITZ)-loaded pectin nanoparticles prepared from nanoemulsion templates is described, and the results demonstrated that the morphology of freeze-dried products was different, depending on the type of internal phase.

TL;DR: Results indicate that HME with Soluplus ®, which can induce supersaturation by micelle formation, may be of great assistance to the successful development of poorly water-soluble drugs.

TL;DR: In this article, solid dispersions of ARM with polymers were prepared with Soluplus, Kollidon VA 64, HPMC and Eudragit EPO at weight ratios of 1:1, 1:2, and 1:3 using spray drying technology, and characterized by Fourier transform infrared spectroscopy, differential scanning calorimetry (DSC), and X-ray powder diffraction (XRD) to identify the physicochemical interaction between drug and carrier, as well as effect on dissolution.

TL;DR: In this article, the authors investigate the probable mechanism that actuates opposite polarities between two different size fractions of the same material by analyzing the charge transfer patterns of two different sizes of microcrystalline cellulose (MCC).

TL;DR: In this paper, the theoretical foundation for salts is given with an emphasis on the amount of drug in solution, and general guidelines are described for screening, preparing and characterizing drugs as salts, which critically depend on the goal of the product development.

TL;DR: In this article, an innovative topical ointment containing betamethasone dipropionate loaded nanostructured lipid carrier (BD-NLC) for the treatment of atopic dermatitis (AD) was designed.

TL;DR: In this paper, the authors developed a spray-dried formulation of valsartan using Eudragit® E PO (EPO) as the carrier for enhancing dissolution rate in a gastric environment.

TL;DR: In this paper, a central composite face centered design (CCFD) was used to investigate the influence of the ratio of lipid to protectant (mannitol and trehalose) and crystallinity of spray-dried powder on the particle size, yield and residual moisture content of the dried powder.

TL;DR: The proposed classification system lays a framework for a better understanding of powder interactions during compaction and potential applications and limitations of this classification system are discussed.

TL;DR: Investigation of the effect of surface biotin density on the pharmacokinetic profile of liposomes found that a proper amount of biotin liposome with 0.5% molar ratio is expected to produce the best anti-tumor effect.

TL;DR: In this paper, the influence of supercritical CO 2 processing on the particle size and morphology of puerarin crystals was investigated, and the results showed that this process has the potential to produce a drug recrystallization product with newly generated crystal forms and the size of drug particles could be controlled through the tuning of various experimental conditions.

TL;DR: In this paper, a combination of fluid bed and microparticles (MSM) was used to improve drug loading and dissolution for poorly water-soluble drugs, and the results showed that the combination was an effective strategy for improving drug loading as well as dissolution.

TL;DR: In this article, the authors investigated whether Raman and Near Infrared (NIR) spectroscopy could predict tablet properties, and they used partial least squares (PLS) regression to correlate spectral information to tablet properties.

TL;DR: In this paper, an improved total quality assessment method for Chrysanthemum indicum Flower by simultaneous quantitation using a single standard to determine multi-components method combined with high performance liquid chromatography fingerprint analysis was described.

TL;DR: In this article, a novel polyelectrolyte complex nanoparticles (AAP/LCS NPs) were prepared by mixing negatively charged auricularia auricular polysaccharide with positively charged low molecular weight chitosan (LCS) in an aqueous medium.

TL;DR: In this paper, a proprietary roller compactor was used to produce granulate from a placebo formulation, and the results demonstrate several rheological properties of the granulate, which have been shown to be closely correlated with variance in die filling and tablet strength, and are predictably influenced by the processing parameters.

TL;DR: Glutathione proves to be an efficient vector for the successful transport of poor bioavailable drug to the brain in nanoparticles constructed using PLGA polymer for the effective targeted delivery to brain via nasal route.

TL;DR: The number of particle delivery systems for biologics is negligible compared to liquid dosage forms, signifying the complications associated with development of solid protein delivery systems as mentioned in this paper. But particle delivery can improve stability, reduce viscosity of suspensions at high protein concentration and allow for controlled drug release.

TL;DR: In this article, the oleanolic acid-phospholipid complex (OA-PC) was optimized and the type and proportion of fumed silica were studied by dissolution text.

TL;DR: In this paper, the β-sitosterol-loaded nanofibers were freely water-soluble and exhibited very short lag-time in releasing the plant sterol.