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Showing papers in "Behavioural Brain Research in 2004"


Journal ArticleDOI
TL;DR: It is suggested that chronic SI increases emotional reactivity to stress and produces a hyperfunction of the HPA axis in adult rats, particularly in males.

458 citations


Journal ArticleDOI
TL;DR: Results show both an anhedonic-like and an amnesic effect of UCMS in CBA/H mice and reveal a difference of sensitivity to UCMS according to the strain of mice.

371 citations


Journal ArticleDOI
TL;DR: The Morris water task and the eight-arm radial maze do not assess spatial memory in the same manner, and even after equating factors such as motivation, stress, and motor demands, there still are procedural demands of the tasks that reinforce differential strategy selection during spatial memory.

327 citations


Journal ArticleDOI
TL;DR: It is indicated that the observed functional deficits can be related to cell degeneration induced during a critical stage of neonatal brain development and the potentiated apoptosis induced by ketamine and diazepam may have implications for the selection of drugs used in neonatal paediatric anaesthesia.

230 citations


Journal ArticleDOI
TL;DR: Interactions indicate that behavioural responding of pigs with diverging coping characteristics cannot simply be generalised across rearing conditions and that they have a higher propensity to develop inflexible behavioural routines.

230 citations


Journal ArticleDOI
TL;DR: The data suggest that KO mice may serve as a useful animal model for understanding not only how DA dysfunction contributes to social abnormalities, but also how behavioral inflexibility distorts their social responses.

202 citations


Journal ArticleDOI
TL;DR: The results suggest that male and female rats may harbor brain circuitry that is equally capable of accurate spatial navigation and memory in the WM but which may be impaired to different degrees by the differential stress responses triggered by WM testing.

199 citations


Journal ArticleDOI
TL;DR: Data support the contention that the NR1 hypomorphic mice exhibit alterations in sensorimotor gating and typical conspecific interactions, reminiscent of behavioral disturbances associated with schizophrenia, and could represent a model system to explore novel treatment and preventative strategies for certain symptoms of schizophrenia.

198 citations


Journal ArticleDOI
TL;DR: It is concluded that long-term voluntary exercise appears to result in decreased anxiety-related behaviour and impulsiveness, which fit into the concept that regular exercise strengthens endogenous stress coping mechanisms, thereby protecting the organism against the deleterious effects of stress.

180 citations


Journal ArticleDOI
TL;DR: Epo treatment immediately after hypoxic-ischemic insult significantly improved long-term neurobehavioral achievements when tested during the subsequent phase of brain maturation and even into adulthood, suggesting this agent may be potentially beneficial in treating asphyxial brain damage in the perinatal period.

177 citations


Journal ArticleDOI
TL;DR: Tart cherry anthocyanins extracted from tart cherries reduce inflammation-induced thermal hyperalgesia, mechanical hyper algesia and paw edema, and these data suggest that tart cherry anthcyanins may have a beneficial role in the treatment of inflammatory pain.

Journal ArticleDOI
TL;DR: Whether oxidative stress contributes to the memory deficits induced by intracerebroventricular injection of Abeta (1-42) in mice is examined and the antioxidant alpha-tocopherol significantly prevented these oxidative stresses.

Journal ArticleDOI
TL;DR: It is concluded that environmental enrichment has positive effects that are independent of the effects of ischemic brain lesions, and brain-derived neurotrophic factor levels were increased in environmental enrichment animals compared to those housed in standard conditions.

Journal ArticleDOI
TL;DR: The present experiments demonstrate that lesions of perirhinal cortex in the rat cause impairments in object recognition which increase with the level of feature ambiguity present in the discrimination.

Journal ArticleDOI
TL;DR: There was a significant correlation between maternal behaviors and both PPI and the performance in the attentional set shifting task andArtificially-reared rats that were provided with 'maternal-like licking' stimulation, during artificial rearing, were not significantly different from mother- reared rats.

Journal ArticleDOI
TL;DR: It is demonstrated that prenatal nicotine exposure produced significant long-term developmental and behavioral teratogenic effects.

Journal ArticleDOI
TL;DR: These findings were interpreted based on more detailed analysis of the behavioral data and considerations of the complex nature and multiple roles of the neuregulin/erbB4 system in the nervous system.

Journal ArticleDOI
TL;DR: Correlation analysis showed that animals that had less consumption of sucrose spent more time in REM sleep and had increased number of REM sleep episodes, and CMS appears to be a model of depression.

Journal ArticleDOI
TL;DR: A possible involvement of IL-6 on memory processes is suggested, even if the mechanism remains still unclear, using a passive avoidance and an eight-arm radial maze tasks.

Journal ArticleDOI
TL;DR: It is concluded that the neuron-specific non-messenger BC1 RNA contributes to the aptive modulation of behaviour in rodents that show behavioural changes best interpreted in terms of reduced exploration and increased anxiety.

Journal ArticleDOI
TL;DR: The results suggest that different stress models have different degrees of influences on enzymatic and non-enzymatic antioxidant defense systems, protein oxidation and lipid peroxidation in the brain.

Journal ArticleDOI
TL;DR: The results suggest that the hippocampal CA3-region is essential for spatial memory processes and specifically in memory consolidation of spatial information.

Journal ArticleDOI
TL;DR: In this article, the authors examined the hypothesis that Vitamin D deficiency during early development alters adult behaviour even when there is an intervening period in which the animal receives normal Vitamin D in later development.

Journal ArticleDOI
TL;DR: The results of these experiments indicate that adenosine A2A antagonism can reverse the locomotor suppression and tremulous movements induced by DA antagonism, consistent with the hypothesis that antagonism of adenosines A 2A receptors can result in an antiparkinsonian effect in animal models.

Journal ArticleDOI
TL;DR: Data show that an animal model of OLAN-induced weight gain is readily generated, and suggest that the weight gain results at least in part from increased food intake, reduced gross motor activity, and enhanced feed efficiency.

Journal ArticleDOI
TL;DR: This is the first demonstration of a double dissociation of early social and inanimate stimulation on two distinct behavioural functions that are mediated by dissociable underlying neural pathways, and strengthens the view that social andInanimate stimulation act, at least in part, upon dissociables neural substrates.

Journal ArticleDOI
TL;DR: It is indicated that DA depletions make animals sensitive to temporal or rate components of work that greatly influence responding on ratio schedules and relatively insensitive to different force requirements within the range tested.

Journal ArticleDOI
TL;DR: It is found that rats direct greater exploration at a novel than a familiar arm location, thus showing long-term spatial recognition memory, and at an older familiar arm than a more recent familiar arm, thus show long- term spatial temporal order memory.

Journal ArticleDOI
TL;DR: Findings represent the first evidence that brain asymmetry modulates immune responses in dogs and show that lymphocytes cells were higher in left-pawed than in right-paws and ambidextrous dogs.

Journal ArticleDOI
TL;DR: Findings show that lesion size is a critical factor and may explain why some studies have failed to find comparable deficits after retrosplenial cortex lesions.